| Configuration: FUJISAN | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.943 AUROC unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceFUJISAN: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features; Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, FUJISAN row, AUROC column |
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| Configuration: ESM2 | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.799 AUROC unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceESM2: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features; Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, ESM2 row, AUROC column |
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| Configuration: E-value | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 78.6% PRE (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceE-value: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row E-value, column PRE (%); XML row3 column3 |
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| Configuration: FUJISAN | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 87% REC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceFUJISAN: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row FUJISAN, column REC (%); XML row2 column4 |
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| Configuration: ESM2 | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 79.3% REC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceESM2: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column REC (%); XML row5 column4 |
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| Configuration: E-value | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.829 F1 dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceE-value: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row E-value, column F1; XML row3 column6 |
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| Configuration: ESM2 | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.815 AUPR dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceESM2: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column AUPR; XML row5 column9 |
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| Configuration: FUJISAN | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.742 MCC dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceFUJISAN: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row FUJISAN, column MCC; XML row2 column7 |
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| Configuration: DeepFRI | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 83.2% REC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDeepFRI: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row DeepFRI, column REC (%); XML row4 column4 |
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| Configuration: Pfam | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 62% ACC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcePfam: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row Pfam, column ACC (%); XML row6 column2 |
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| Configuration: E-value | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.643 MCC dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceE-value: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row E-value, column MCC; XML row3 column7 |
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| Configuration: DeepFRI | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 80.9% ACC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDeepFRI: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row DeepFRI, column ACC (%); XML row4 column2 |
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| Configuration: ESM2 | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.432 MCC dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceESM2: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column MCC; XML row5 column7 |
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| Configuration: DeepFRI | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.679 MCC dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDeepFRI: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row DeepFRI, column MCC; XML row4 column7 |
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| Configuration: Pfam | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.352 MCC dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcePfam: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row Pfam, column MCC; XML row6 column7 |
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| Configuration: Pfam | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 56.9% PRE (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcePfam: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row Pfam, column PRE (%); XML row6 column3 |
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| Configuration: E-value | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 23.9% FPR (%) percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceE-value: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row E-value, column FPR (%); XML row3 column5 |
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| Configuration: E-value | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 87.8% REC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceE-value: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row E-value, column REC (%); XML row3 column4 |
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| Configuration: Pfam | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.722 F1 dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcePfam: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row Pfam, column F1; XML row6 column6 |
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| Configuration: E-value | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 81.9% ACC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceE-value: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row E-value, column ACC (%); XML row3 column2 |
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| Configuration: DeepFRI | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 0.814 F1 dimensionless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDeepFRI: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row DeepFRI, column F1; XML row4 column6 |
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| Configuration: Pfam | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 74.6% FPR (%) percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcePfam: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row Pfam, column FPR (%); XML row6 column5 |
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| Configuration: FUJISAN | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 87.2% PRE (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceFUJISAN: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row FUJISAN, column PRE (%); XML row2 column3 |
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| Configuration: Pfam | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 98.6% REC (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcePfam: Enzyme-pair functional identity: original held-out test LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row Pfam, column REC (%); XML row6 column4 |
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| Configuration: ESM2 | Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) Dataset: FUJISAN test sub-dataset | 68.4% PRE (%) percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceESM2: Enzyme functional identity prediction LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split. Aggregation: Not reported Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column PRE (%); XML row5 column3 |
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