rewirebio.iobenchmarks
Evaluation

ESM2: Enzyme functional identity prediction

Evaluation results

1 evaluation · 8 results. Different protocols are not a single leaderboard.

Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction) · Dataset: FUJISAN test sub-dataset

Sorted by Accuracy (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationAccuracyAUPRCAUROCF1False positive rateMCCPrecisionRecall
ESM2Evaluation71.3%0.8150.7990.73536.7%0.43268.4%79.3%
All 8 result rows with coverage, uncertainty and sources
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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.799 AUROC
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features; Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, ESM2 row, AUROC column
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
79.3% Recall
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column REC (%); XML row5 column4
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.815 AUPRC
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column AUPR; XML row5 column9
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.432 MCC
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column MCC; XML row5 column7
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
68.4% Precision
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column PRE (%); XML row5 column3
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.735 F1
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column F1; XML row5 column6
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
71.3% Accuracy
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column ACC (%); XML row5 column2
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
36.7% False positive rate
percent · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column FPR (%); XML row5 column5

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-11-02-a7f03c9e55a5 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

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Verified: Not verified

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Missing or unresolved evidence

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  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
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Verified: Not verified

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Verified: Not verified

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Validate independently

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Missing or unresolved evidence

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  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

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Evaluation procedure

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Configuration
ESM2
Protocol
Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset
FUJISAN test sub-dataset
origin
Independent external evaluation
configuration
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
protocol id
paper-protocol-7088bcc2f0033b8a29
dataset version
Not reported
split
41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.
subset
Enzyme-pair functional identity: original held-out test
population
Not reported
aggregation
Not reported
inputs
Not reported
adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
budget
Not reported
metric implementation
Not reported

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Reproduction

Split
41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.
Adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

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38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: budget
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: inputs
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: inputs
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

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Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: needs review

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: evaluation-lit-020

areas
proteins-complexes
tasks
Enzyme functional identity prediction
origin
independent_paper
protocol
LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.
version
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
comparison
protocol id: paper-protocol-7088bcc2f0033b8a29; dataset version: Not reported; split: 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.; subset: Enzyme-pair functional identity: original held-out test; population: Not reported; aggregation: Not reported; inputs: Not reported; adaptation: Paper-specific evaluated pipeline; exact checkpoint not inferred from label; budget: Not reported; metric implementation: Not reported
missing metadata
budget: reason: unreported; checkpoint revision: reason: unextracted; split manifest: reason: unextracted
source locator
Table 1: AUPR, Enzyme-pair functional identity: original held-out test
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