rewire.itbenchmarks
Evaluation

ESM2: Enzyme functional identity prediction

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-09-29-06401fd5b220 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 8 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.799 AUROC
unitless · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features; Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, ESM2 row, AUROC column
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
79.3% REC (%)
percent · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column REC (%); XML row5 column4
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.815 AUPR
dimensionless · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column AUPR; XML row5 column9
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.432 MCC
dimensionless · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column MCC; XML row5 column7
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
68.4% PRE (%)
percent · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column PRE (%); XML row5 column3
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
0.735 F1
dimensionless · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column F1; XML row5 column6
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
71.3% ACC (%)
percent · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column ACC (%); XML row5 column2
Configuration: ESM2Protocol: Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset: FUJISAN test sub-dataset
36.7% FPR (%)
percent · lower

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESM2: Enzyme functional identity prediction

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Aggregation: Not reported

Enhanced prediction of protein functional identity through the integration of sequence and structural features · Table 1, row ESM2, column FPR (%); XML row5 column5

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

Evaluation procedure

LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.

Configuration
ESM2
Protocol
Enzyme-pair functional identity: original held-out test (Enzyme functional identity prediction)
Dataset
FUJISAN test sub-dataset
origin
Independent external evaluation
configuration
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
protocol id
paper-protocol-7088bcc2f0033b8a29
dataset version
Not reported
split
41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.
subset
Enzyme-pair functional identity: original held-out test
population
Not reported
aggregation
Not reported
inputs
Not reported
adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
budget
Not reported
metric implementation
Not reported

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Reproduction

Split
41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.
Adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.aggregation
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.dataset_version
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.inputs
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-16T10:33:35.728Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Not reported
Context-only references
Enhanced prediction of protein functional identity through the integration of sequence and structural features

Original source ↗

Table 1: AUPR, Enzyme-pair functional identity: original held-out test

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: PMC11609699.1
Retrieved: 2026-09-17T07:56:15.783679+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: db33e0542005ffae00cd644dfe697185b94c8823d5aee2768620a6db0c48e56f

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-29-06401fd5b220 · Record review: needs review

2 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: evaluation-lit-020

areas
proteins-complexes
tasks
Enzyme functional identity prediction
origin
independent_paper
protocol
LightGBM FUJISAN and comparison methods; predictions thresholded to maximizeF 1. Protein-pair splitting is not evidence of disjoint proteins or families. 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.
version
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
comparison
protocol id: paper-protocol-7088bcc2f0033b8a29; dataset version: Not reported; split: 41,600 protein pairs; balanced functional-identity classes; random 56.25/18.75/25% training/validation/test split.; subset: Enzyme-pair functional identity: original held-out test; population: Not reported; aggregation: Not reported; inputs: Not reported; adaptation: Paper-specific evaluated pipeline; exact checkpoint not inferred from label; budget: Not reported; metric implementation: Not reported
missing metadata
checkpoint revision: unextracted; budget: unreported; split manifest: unextracted
source locator
Table 1: AUPR, Enzyme-pair functional identity: original held-out test
Related records

Suggest a correction