rewirebio.iobenchmarks
Dataset

Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)

Eight CRISPR perturbation screens (Perturb-seq, DC-TAP-seq, CRISPRi-FlowFISH) in K562, GM12878, HCT116, WTC11 and Jurkat, excluding pairs in the training data.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-10-7fcc3e48a123 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

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  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
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Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

6 evaluations · 18 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.465 auprc
fraction · higher

Uncertainty: 95% CI 0.378228901913079 to 0.541415553632906

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ABC_A=DNase, C=Average ENCODE Hi-C on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 2 (D2:F2); Dataset 'Held-out', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted AUPRC'
Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.437 precision
fraction · higher

Uncertainty: 95% CI 0.375298718902513 to 0.497269228021238

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ABC_A=DNase, C=Average ENCODE Hi-C on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 8 (D8:F8); Dataset 'Held-out', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted precision at threshold'
Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.619 recall
fraction · higher

Uncertainty: 95% CI 0.547527036355901 to 0.688813573106359

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ABC_A=DNase, C=Average ENCODE Hi-C on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 14 (D14:F14); Dataset 'Held-out', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted recall at threshold'
Configuration: Distance to TSS (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.363 auprc
fraction · higher

Uncertainty: 95% CI 0.281241216228264 to 0.437896240213437

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Distance to TSS on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 6 (D6:F6); Dataset 'Held-out', Predictor 'Distance to TSS', metric 'Weighted AUPRC'
Configuration: Distance to TSS (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.245 precision
fraction · higher

Uncertainty: 95% CI 0.202048095028741 to 0.288268461392336

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Distance to TSS on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 12 (D12:F12); Dataset 'Held-out', Predictor 'Distance to TSS', metric 'Weighted precision at threshold'
Configuration: Distance to TSS (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.584 recall
fraction · higher

Uncertainty: 95% CI 0.511553237372335 to 0.655007748643397

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Distance to TSS on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 18 (D18:F18); Dataset 'Held-out', Predictor 'Distance to TSS', metric 'Weighted recall at threshold'
Configuration: ENCODE-rE2G (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.556 auprc
fraction · higher

Uncertainty: 95% CI 0.467852411496632 to 0.631223913857611

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ENCODE-rE2G on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 3 (D3:F3); Dataset 'Held-out', Predictor 'ENCODE-rE2G', metric 'Weighted AUPRC'
Configuration: ENCODE-rE2G (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.544 precision
fraction · higher

Uncertainty: 95% CI 0.473562214144615 to 0.614971149178317

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ENCODE-rE2G on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 9 (D9:F9); Dataset 'Held-out', Predictor 'ENCODE-rE2G', metric 'Weighted precision at threshold'
Configuration: ENCODE-rE2G (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.599 recall
fraction · higher

Uncertainty: 95% CI 0.526506289907121 to 0.670411257697732

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ENCODE-rE2G on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 15 (D15:F15); Dataset 'Held-out', Predictor 'ENCODE-rE2G', metric 'Weighted recall at threshold'
Configuration: Correlation_E-P DNase-seq signal (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.211 auprc
fraction · higher

Uncertainty: 95% CI 0.155299843477219 to 0.267454116811189

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Correlation_E-P DNase-seq signal on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 7 (D7:F7); Dataset 'Held-out', Predictor 'Correlation_E-P DNase-seq signal', metric 'Weighted AUPRC'
Configuration: Correlation_E-P DNase-seq signal (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.112 precision
fraction · higher

Uncertainty: 95% CI 0.09490444 to 0.130640831462308

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Correlation_E-P DNase-seq signal on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 13 (D13:F13); Dataset 'Held-out', Predictor 'Correlation_E-P DNase-seq signal', metric 'Weighted precision at threshold'
Configuration: Correlation_E-P DNase-seq signal (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.737 recall
fraction · higher

Uncertainty: 95% CI 0.669820594780111 to 0.79971637

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Correlation_E-P DNase-seq signal on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 19 (D19:F19); Dataset 'Held-out', Predictor 'Correlation_E-P DNase-seq signal', metric 'Weighted recall at threshold'
Configuration: EpiMap (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.268 auprc
fraction · higher

Uncertainty: 95% CI 0.202767496369732 to 0.342972872868445

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

EpiMap on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 5 (D5:F5); Dataset 'Held-out', Predictor 'EpiMap', metric 'Weighted AUPRC'
Configuration: EpiMap (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.292 precision
fraction · higher

Uncertainty: 95% CI 0.244244656893669 to 0.342593944957384

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

EpiMap on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 11 (D11:F11); Dataset 'Held-out', Predictor 'EpiMap', metric 'Weighted precision at threshold'
Configuration: EpiMap (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.545 recall
fraction · higher

Uncertainty: 95% CI 0.471122984227133 to 0.616597040982763

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

EpiMap on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 17 (D17:F17); Dataset 'Held-out', Predictor 'EpiMap', metric 'Weighted recall at threshold'
Configuration: EPIraction (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.383 auprc
fraction · higher

Uncertainty: 95% CI 0.302549537433103 to 0.455764606497437

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

EPIraction on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 4 (D4:F4); Dataset 'Held-out', Predictor 'EPIraction', metric 'Weighted AUPRC'
Configuration: EPIraction (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.347 precision
fraction · higher

Uncertainty: 95% CI 0.292942536891562 to 0.401809875530837

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

EPIraction on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 10 (D10:F10); Dataset 'Held-out', Predictor 'EPIraction', metric 'Weighted precision at threshold'
Configuration: EPIraction (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.596 recall
fraction · higher

Uncertainty: 95% CI 0.525947724997951 to 0.666054834012973

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

EPIraction on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 16 (D16:F16); Dataset 'Held-out', Predictor 'EPIraction', metric 'Weighted recall at threshold'

Source checking is not independent reproduction. Release 2026-10-10-7fcc3e48a123.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

16 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-7fcc3e48a123
Property and statementOriginal source and locationReview and provenance
attributes.population
4,378 element-gene pairs, 190 positives (157.39 weighted); elements overlapping promoters or the target gene body removed; positives without H3K27ac removed; negatives filtered for power
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population
4,378 element-gene pairs, 190 positives (157.39 weighted); elements overlapping promoters or the target gene body removed; positives without H3K27ac removed; negatives filtered for power
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.positives
190
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.positives

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.positives
190
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.positives

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.source_locator
Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.source_locator
Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.split
Held out from ENCODE-rE2G training
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.split

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.split
Held out from ENCODE-rE2G training
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.split

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.total
4378
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

Audit details

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Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

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attributes.total
4378
Context-only references
Gschwind et al. 2026, Supplementary Table 3

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Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'

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Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

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Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

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Sources and history

Release 2026-10-10-7fcc3e48a123 · Record review: source checked

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Stable ID: regulatory-variant-20261009-data-gschwind2026-heldout-crispr

areas
dna-genomes
contexts
research
version
As published (Methods 'Creating the combined held-out CRISPR dataset')
total
4378
positives
190
population
4,378 element-gene pairs, 190 positives (157.39 weighted); elements overlapping promoters or the target gene body removed; positives without H3K27ac removed; negatives filtered for power
split
Held out from ENCODE-rE2G training
source locator
Figure 2 legend (panel d); Methods 'Creating the combined held-out CRISPR dataset'
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