ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026)
ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) as evaluated in the cited comparison.
Overview
ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) as evaluated in the cited comparison.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
2 evaluations · 6 results. Different protocols are not a single leaderboard.
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) | Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3) Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026) | 0.465 auprc fraction · higher Uncertainty: 95% CI 0.378228901913079 to 0.541415553632906 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceABC_A=DNase, C=Average ENCODE Hi-C on held-out CRISPR pairs, five cell types regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted Aggregation: Not reported An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 2 (D2:F2); Dataset 'Held-out', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted AUPRC' |
| Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) | Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3) Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026) | 0.437 precision fraction · higher Uncertainty: 95% CI 0.375298718902513 to 0.497269228021238 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceABC_A=DNase, C=Average ENCODE Hi-C on held-out CRISPR pairs, five cell types regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted Aggregation: Not reported An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 8 (D8:F8); Dataset 'Held-out', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted precision at threshold' |
| Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) | Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3) Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026) | 0.619 recall fraction · higher Uncertainty: 95% CI 0.547527036355901 to 0.688813573106359 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceABC_A=DNase, C=Average ENCODE Hi-C on held-out CRISPR pairs, five cell types regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted Aggregation: Not reported An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 14 (D14:F14); Dataset 'Held-out', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted recall at threshold' |
| Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) | Protocol: Combined K562 CRISPR training pairs, weighted metrics (Gschwind et al. 2026 Supplementary Table 3) Dataset: MPRabc K562 CRISPRi benchmark | 0.561 auprc fraction · higher Uncertainty: 95% CI 0.505742840168912 to 0.609499053593117 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceABC_A=DNase, C=Average ENCODE Hi-C on combined K562 CRISPR training pairs regulatory-variant-20261009-protocol-gschwind2026-k562-training-weighted Aggregation: Not reported An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 20 (D20:F20); Dataset 'Combined K562 (training)', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted AUPRC' |
| Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) | Protocol: Combined K562 CRISPR training pairs, weighted metrics (Gschwind et al. 2026 Supplementary Table 3) Dataset: MPRabc K562 CRISPRi benchmark | 0.453 precision fraction · higher Uncertainty: 95% CI 0.413472264469473 to 0.492071262218147 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceABC_A=DNase, C=Average ENCODE Hi-C on combined K562 CRISPR training pairs regulatory-variant-20261009-protocol-gschwind2026-k562-training-weighted Aggregation: Not reported An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 26 (D26:F26); Dataset 'Combined K562 (training)', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted precision at threshold' |
| Configuration: ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026) | Protocol: Combined K562 CRISPR training pairs, weighted metrics (Gschwind et al. 2026 Supplementary Table 3) Dataset: MPRabc K562 CRISPRi benchmark | 0.739 recall fraction · higher Uncertainty: 95% CI 0.69600194650038 to 0.782655613574707 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceABC_A=DNase, C=Average ENCODE Hi-C on combined K562 CRISPR training pairs regulatory-variant-20261009-protocol-gschwind2026-k562-training-weighted Aggregation: Not reported An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 32 (D32:F32); Dataset 'Combined K562 (training)', Predictor 'ABC_A=DNase, C=Average ENCODE Hi-C', metric 'Weighted recall at threshold' |
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Evidence
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Sources and history
Release 2026-10-10-6e93f504adfc · Record review: source checked
2 source records and release history
- An encyclopedia of human enhancer-gene regulatory interactions · Original source · Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
- Gschwind et al. 2026, Supplementary Table 3 · Original source · Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Technical metadata and extraction receipts
Stable ID: regulatory-variant-20261009-config-gschwind2026-abc-dnase-avg-hic
- areas
- dna-genomes
- contexts
- research
- method types
- conventional_pipeline
- reported name
- ABC_A=DNase, C=Average ENCODE Hi-C (Gschwind et al. 2026)
- foundation model eligible
- false
- missing metadata
- version: reason: unreported; note: Predictor version not printed in Supplementary Table 3; parameters are in Supplementary Table 1 (not read)
- parameters
- Activity from DNase-seq, contact from average ENCODE Hi-C
- source locator
- Supplementary Table 3 'Held-out benchmarks', predictor 'ABC_A=DNase, C=Average ENCODE Hi-C'