rewirebio.iobenchmarks
Evaluation

Distance to TSS on held-out CRISPR pairs, five cell types

Published comparison; transcribed, not reproduced.

Research readiness

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Release 2026-10-10-6e93f504adfc · Evidence verified: Not verified

Evidence incomplete

Replay metrics

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Verified: Not verified

Evidence incomplete

Investigate discrepancies

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Missing or unresolved evidence

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  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

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  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
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Verified: Not verified

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Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

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  • independent validation: verification is missing
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Verified: Not verified

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No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 3 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Distance to TSS (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.363 auprc
fraction · higher

Uncertainty: 95% CI 0.281241216228264 to 0.437896240213437

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Distance to TSS on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 6 (D6:F6); Dataset 'Held-out', Predictor 'Distance to TSS', metric 'Weighted AUPRC'
Configuration: Distance to TSS (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.245 precision
fraction · higher

Uncertainty: 95% CI 0.202048095028741 to 0.288268461392336

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Distance to TSS on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 12 (D12:F12); Dataset 'Held-out', Predictor 'Distance to TSS', metric 'Weighted precision at threshold'
Configuration: Distance to TSS (Gschwind et al. 2026)Protocol: Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset: Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
0.584 recall
fraction · higher

Uncertainty: 95% CI 0.511553237372335 to 0.655007748643397

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Distance to TSS on held-out CRISPR pairs, five cell types

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Aggregation: Not reported

An encyclopedia of human enhancer-gene regulatory interactions; Gschwind et al. 2026, Supplementary Table 3 · Supplementary Table 3 'Held-out benchmarks', row 18 (D18:F18); Dataset 'Held-out', Predictor 'Distance to TSS', metric 'Weighted recall at threshold'

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

Evaluation procedure

regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Configuration
Distance to TSS (Gschwind et al. 2026)
Protocol
Held-out CRISPR enhancer-gene benchmark, weighted metrics, five cell types (Gschwind et al. 2026 Supplementary Table 3)
Dataset
Held-out CRISPR enhancer-gene pairs in five cell types (Gschwind et al. 2026)
origin
Author-reported evaluation
configuration
Primary source as retrieved 2026-10-09
dataset version
As published
split
Held out from training
population
4,378 pairs, 190 positives
inputs
Predictor's genome-wide element-gene scores in the matching cell type
adaptation
Not reported
metric implementation
yardstick 1.2.0 weighted precision-recall; boot 1.3-28.1
aggregation
Pooled over pairs, weighted
budget
Not reported
protocol id
regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Held out from training
Adaptation
Not reported
Scoring implementation
yardstick 1.2.0 weighted precision-recall; boot 1.3-28.1

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Not reported
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
Not reported
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.comparison.aggregation
Pooled over pairs, weighted
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Pooled over pairs, weighted
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.comparison.dataset_version
As published
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
As published
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

attributes.comparison.inputs
Predictor's genome-wide element-gene scores in the matching cell type
Context-only references
An encyclopedia of human enhancer-gene regulatory interactions

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 657(8130):179, published online 2026-07-15; PMC13471189 full-text XML
Retrieved: 2026-10-09T21:03:18Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: df07ed8c37a62732ba0ae26b74a6c8bcb9b48540fefd03c064115d9a87a3b642

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Predictor's genome-wide element-gene scores in the matching cell type
Context-only references
Gschwind et al. 2026, Supplementary Table 3

Original source ↗

Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary_Table_3.xlsx in 41586_2026_10781_MOESM3_ESM.zip (folder 2023-11-20318B-s3) inside the Europe PMC supplementaryFiles zip
Retrieved: 2026-10-09T21:04:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 81f7f2a3c4379adfca9db362a3aa2c2a8b4121bed0a54337a747f9afeee85904

Hash scope: SHA-256 of the xlsx member. MOESM3 zip SHA-256 88eb6c5239019cbec55281b545a3b6e450e2a83384d067ca94a0974968428332; outer supplementaryFiles zip SHA-256 78dc8641d9c6861568465c274b80329f7046bf7a0145c2546deb422f9a2c0930 (assembled per request).

Inspected artifact

Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: regulatory-variant-20261009-eval-gschwind2026-heldout-distance-to-tss

areas
dna-genomes
contexts
research
origin
author_reported
protocol
regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted
version
Primary source as retrieved 2026-10-09
comparison
dataset version: As published; split: Held out from training; population: 4,378 pairs, 190 positives; inputs: Predictor's genome-wide element-gene scores in the matching cell type; adaptation: Not reported; metric implementation: yardstick 1.2.0 weighted precision-recall; boot 1.3-28.1; aggregation: Pooled over pairs, weighted; budget: Not reported; protocol id: regulatory-variant-20261009-protocol-gschwind2026-heldout-weighted
source locator
Supplementary Table 3 'Held-out benchmarks', Dataset 'Held-out', Predictor 'Distance to TSS'
limitations
Developer of the predictor is an author of the comparison.
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