Dataset

Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)

Plasma cfDNA whole-genome sequencing cohort reanalysed by Hou et al. 2024.

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Evaluation results

10 evaluations · 30 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Fragment 5' end motif (4-mer), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.535 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EDM (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C32; data set 'Mathios et al. independent dataset (LUNG)'; row 'EDM'; column 'AUC'
Configuration: Fragment 5' end motif (4-mer), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.174 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EDM (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E32; data set 'Mathios et al. independent dataset (LUNG)'; row 'EDM'; column 'Sensitivity @85% specificity'
Configuration: Fragment 5' end motif (4-mer), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.0652 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EDM (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D32; data set 'Mathios et al. independent dataset (LUNG)'; row 'EDM'; column 'Sensitivity @95% specificity'
Configuration: Fragment coverage (fragment midpoint counts), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.84 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source coverage (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C27; data set 'Mathios et al. independent dataset (LUNG)'; row 'coverage'; column 'AUC'
Configuration: Fragment coverage (fragment midpoint counts), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.652 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source coverage (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E27; data set 'Mathios et al. independent dataset (LUNG)'; row 'coverage'; column 'Sensitivity @85% specificity'
Configuration: Fragment coverage (fragment midpoint counts), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.457 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source coverage (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D27; data set 'Mathios et al. independent dataset (LUNG)'; row 'coverage'; column 'Sensitivity @95% specificity'
Configuration: Fragment endpoint counts, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.83 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source end (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C28; data set 'Mathios et al. independent dataset (LUNG)'; row 'end'; column 'AUC'
Configuration: Fragment endpoint counts, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.696 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source end (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E28; data set 'Mathios et al. independent dataset (LUNG)'; row 'end'; column 'Sensitivity @85% specificity'
Configuration: Fragment endpoint counts, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.522 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source end (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D28; data set 'Mathios et al. independent dataset (LUNG)'; row 'end'; column 'Sensitivity @95% specificity'
Configuration: Fragment length distribution, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.867 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source length (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C23; data set 'Mathios et al. independent dataset (LUNG)'; row 'length'; column 'AUC'
Configuration: Fragment length distribution, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.674 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source length (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E23; data set 'Mathios et al. independent dataset (LUNG)'; row 'length'; column 'Sensitivity @85% specificity'
Configuration: Fragment length distribution, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.478 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source length (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D23; data set 'Mathios et al. independent dataset (LUNG)'; row 'length'; column 'Sensitivity @95% specificity'
Configuration: Fragment size distribution (FSD), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.939 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source FSD (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C26; data set 'Mathios et al. independent dataset (LUNG)'; row 'FSD'; column 'AUC'
Configuration: Fragment size distribution (FSD), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.848 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source FSD (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E26; data set 'Mathios et al. independent dataset (LUNG)'; row 'FSD'; column 'Sensitivity @85% specificity'
Configuration: Fragment size distribution (FSD), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.717 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source FSD (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D26; data set 'Mathios et al. independent dataset (LUNG)'; row 'FSD'; column 'Sensitivity @95% specificity'
Configuration: Fragment size ratio (FSR), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.664 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source FSR (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C25; data set 'Mathios et al. independent dataset (LUNG)'; row 'FSR'; column 'AUC'
Configuration: Fragment size ratio (FSR), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.5 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source FSR (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E25; data set 'Mathios et al. independent dataset (LUNG)'; row 'FSR'; column 'Sensitivity @85% specificity'
Configuration: Fragment size ratio (FSR), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.348 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source FSR (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D25; data set 'Mathios et al. independent dataset (LUNG)'; row 'FSR'; column 'Sensitivity @95% specificity'
Configuration: Integrated fragmentation score (IFS), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.838 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source IFS (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C30; data set 'Mathios et al. independent dataset (LUNG)'; row 'IFS'; column 'AUC'
Configuration: Integrated fragmentation score (IFS), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.652 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source IFS (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E30; data set 'Mathios et al. independent dataset (LUNG)'; row 'IFS'; column 'Sensitivity @85% specificity'
Configuration: Integrated fragmentation score (IFS), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.457 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source IFS (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D30; data set 'Mathios et al. independent dataset (LUNG)'; row 'IFS'; column 'Sensitivity @95% specificity'
Configuration: Orientation-aware cell-free fragmentation (OCF), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.823 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source OCF (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C29; data set 'Mathios et al. independent dataset (LUNG)'; row 'OCF'; column 'AUC'
Configuration: Orientation-aware cell-free fragmentation (OCF), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.674 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source OCF (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E29; data set 'Mathios et al. independent dataset (LUNG)'; row 'OCF'; column 'Sensitivity @85% specificity'
Configuration: Orientation-aware cell-free fragmentation (OCF), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.522 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source OCF (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D29; data set 'Mathios et al. independent dataset (LUNG)'; row 'OCF'; column 'Sensitivity @95% specificity'
Configuration: Promoter fragmentation entropy (PFE), open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.81 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source PFE (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C24; data set 'Mathios et al. independent dataset (LUNG)'; row 'PFE'; column 'AUC'

Source checking is not independent reproduction. Release 2026-10-09-ba02f2f4a36e.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

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7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-ba02f2f4a36e
Property and statement	Original source and location	Review and provenance
attributes.assay Plasma cfDNA whole-genome sequencing Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.assay` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.population 431 samples: 385 healthy and 46 lung cancer; BAM files from EGA EGAD00001007796 Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.population` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.source_locator Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.total 431 Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.total` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.version As reanalysed by Hou et al. 2024 (GRCh37) Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.version` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
description Plasma cfDNA whole-genome sequencing cohort reanalysed by Hou et al. 2024. Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded Audit details Field: `description` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
name Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024) Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25) Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded Audit details Field: `name` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-09-ba02f2f4a36e · Record review: source checked

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Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns · Original source · Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML

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Stable ID: ctdnafrag-20261009-data-hou2024-mathios2021-independent

areas: dna-genomes
contexts: clinical_research
version: As reanalysed by Hou et al. 2024 (GRCh37)
population: 431 samples: 385 healthy and 46 lung cancer; BAM files from EGA EGAD00001007796
total: 431
assay: Plasma cfDNA whole-genome sequencing
source locator: Hou et al. 2024 Experimental Section 'Cell-Free DNA Whole Genome Sequencing Data and Preprocessing' (P24-P25)

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