Evaluation

length (open chromatin), independent validation on Mathios et al. independent dataset (LUNG)

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Release 2026-10-09-ba02f2f4a36e · Evidence verified: Not verified

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Evaluation results

1 evaluation · 3 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Fragment length distribution, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.867 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source length (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, C23; data set 'Mathios et al. independent dataset (LUNG)'; row 'length'; column 'AUC'
Configuration: Fragment length distribution, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.674 sensitivity-at-85-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source length (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, E23; data set 'Mathios et al. independent dataset (LUNG)'; row 'length'; column 'Sensitivity @85% specificity'
Configuration: Fragment length distribution, open chromatin regions, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3) Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)	0.478 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source length (open chromatin), independent validation on Mathios et al. independent dataset (LUNG) ctdnafrag-20261009-protocol-hou2024-mathios-independent Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S3, D23; data set 'Mathios et al. independent dataset (LUNG)'; row 'length'; column 'Sensitivity @95% specificity'

Source checking is not independent reproduction. Release 2026-10-09-ba02f2f4a36e.

Evaluation procedure

ctdnafrag-20261009-protocol-hou2024-mathios-independent

Configuration: Fragment length distribution, open chromatin regions, SVM (Hou et al. 2024)
Protocol: Hou et al. 2024 independent validation, Mathios et al. independent lung cohort (Table S3)
Dataset: Mathios et al. 2021 independent lung cohort, 46 lung cancer and 385 healthy (as used by Hou et al. 2024)

origin: Independent external evaluation
configuration: Primary source as retrieved 2026-10-09
protocol id: ctdnafrag-20261009-protocol-hou2024-mathios-independent
dataset version: ctdnafrag-20261009-data-hou2024-mathios2021-independent
split: Independent validation (trained on another cohort)
population: 46 lung cancer vs 385 healthy
inputs: length features in open chromatin regions
adaptation: SVM trained on the training cohort, applied unchanged
metric implementation: Not reported
aggregation: Single validation run; no interval printed
budget: Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split: Independent validation (trained on another cohort)
Adaptation: SVM trained on the training cohort, applied unchanged
Scoring implementation: Not reported

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Evidence table

Inspect claims, sources and review details

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36 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-ba02f2f4a36e
Property and statement	Original source and location	Review and provenance
attributes.comparison.adaptation SVM trained on the training cohort, applied unchanged Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.adaptation SVM trained on the training cohort, applied unchanged Context-only references	Hou et al. 2024, Supporting Information workbook (Tables S1-S15) Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1 Retrieved: 2026-10-09T20:20:39Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.aggregation Single validation run; no interval printed Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.aggregation Single validation run; no interval printed Context-only references	Hou et al. 2024, Supporting Information workbook (Tables S1-S15) Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1 Retrieved: 2026-10-09T20:20:39Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.budget Not reported Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.budget Not reported Context-only references	Hou et al. 2024, Supporting Information workbook (Tables S1-S15) Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1 Retrieved: 2026-10-09T20:20:39Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.dataset_version ctdnafrag-20261009-data-hou2024-mathios2021-independent Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.dataset_version ctdnafrag-20261009-data-hou2024-mathios2021-independent Context-only references	Hou et al. 2024, Supporting Information workbook (Tables S1-S15) Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1 Retrieved: 2026-10-09T20:20:39Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.inputs length features in open chromatin regions Context-only references	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.inputs length features in open chromatin regions Context-only references	Hou et al. 2024, Supporting Information workbook (Tables S1-S15) Original source ↗ Supporting Information Table S3, row 23 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1 Retrieved: 2026-10-09T20:20:39Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Sources and history

Release 2026-10-09-ba02f2f4a36e · Record review: source checked

2 source records and release history

Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns · Original source · Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML
Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Original source · ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1

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Technical metadata and extraction receipts

Stable ID: ctdnafrag-20261009-eval-hou2024-s3-fragment-length-mathios-ind

areas: dna-genomes
contexts: clinical_research
origin: independent_paper
protocol: ctdnafrag-20261009-protocol-hou2024-mathios-independent
version: Primary source as retrieved 2026-10-09
comparison: protocol id: ctdnafrag-20261009-protocol-hou2024-mathios-independent; dataset version: ctdnafrag-20261009-data-hou2024-mathios2021-independent; split: Independent validation (trained on another cohort); population: 46 lung cancer vs 385 healthy; inputs: length features in open chromatin regions; adaptation: SVM trained on the training cohort, applied unchanged; metric implementation: Not reported; aggregation: Single validation run; no interval printed; budget: Not reported
source locator: Supporting Information Table S3, row 23
missing metadata: comparison.metric implementation: reason: unreported

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