Orthrus | configuration

Overview

Best checkpoint of this model family, as selected by the mRNABench authors and listed in their Appendix D.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

10 evaluations · 10 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Orthrus	Task: mRNABench ECLIP: eCLIP binding site prediction Dataset subset: mRNABench eCLIP (mRNABench split)	43.6% auprc percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench ECLIP: eCLIP binding site prediction A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(eCLIP)
Configuration: Orthrus	Task: mRNABench GO: Gene Ontology term prediction Dataset subset: mRNABench GO (mRNABench split)	42.9% auprc percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench GO: Gene Ontology term prediction A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(GO)
Configuration: Orthrus	Task: mRNABench HL: mRNA half life Dataset subset: mRNABench HL (mRNABench split)	0.67 pearson_r correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench HL: mRNA half life A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(HL)
Configuration: Orthrus	Task: mRNABench MRL-HL-PAIR: Paired mean ribosome load and half life Dataset subset: mRNABench MRL-HL-Pair (mRNABench split)	0.51 pearson_r correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench MRL-HL-PAIR: Paired mean ribosome load and half life A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(MRL-HL-Pair)
Configuration: Orthrus	Task: mRNABench MRL-MPRA: Mean ribosome load on an MPRA library Dataset subset: mRNABench MRL MPRA (mRNABench split)	0.63 pearson_r correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench MRL-MPRA: Mean ribosome load on an MPRA library A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(MRL MPRA)
Configuration: Orthrus	Task: mRNABench MRL: Mean ribosome load Dataset subset: mRNABench MRL (mRNABench split)	0.43 pearson_r correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench MRL: Mean ribosome load A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(MRL)
Configuration: Orthrus	Task: mRNABench MRNA-LOC-LR: mRNA localisation, long range Dataset subset: mRNABench mRNA Loc-LR (mRNABench split)	79.8% auprc percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench MRNA-LOC-LR: mRNA localisation, long range A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(mRNA Loc-LR)
Configuration: Orthrus	Task: mRNABench MRNA-LOC-SR: mRNA localisation, short range Dataset subset: mRNABench mRNA Loc-SR (mRNABench split)	77.9% auprc percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench MRNA-LOC-SR: mRNA localisation, short range A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(mRNA Loc-SR)
Configuration: Orthrus	Task: mRNABench PROT-LOC: Protein localisation Dataset subset: mRNABench Prot Loc (mRNABench split)	39.3% auprc percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench PROT-LOC: Protein localisation A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(Prot Loc)
Configuration: Orthrus	Task: mRNABench VEP: Variant effect prediction Dataset subset: mRNABench VEP (mRNABench split)	27% auprc percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Orthrus on mRNABench VEP: Variant effect prediction A linear probe over frozen embeddings, scored as the mean over ten random seeds. Aggregation: Not reported mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(VEP)

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Release 2026-09-29-06401fd5b220 · Record review: source checked

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mRNABench: A curated benchmark for mature mRNA property and function prediction · Original source · preprint archived 2025-07-08

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Technical metadata and extraction receipts

Stable ID: mrnabench-method-orthrus

areas: rna-transcriptomes
source locator: Table 2, row(Orthrus)
missing metadata: checkpoint revision: unreported; parameters: unextracted

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