ProteinGym SUP-SUB-SPEARMAN-CONTIG: Supervised substitutions, contiguous split, Spearman

Overview

Supervised substitutions, contiguous split, Spearman. Scored with Spearman on ProteinGym substitution DMS assays. Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits.

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Results

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Evaluation scope and datasetMetric and reported setup

ProteinGym SUP-SUB-SPEARMAN-CONTIG: Supervised substitutions, contiguous split, Spearman

spearman (correlation) · Higher values are better.

ProteinGym SUP-SUB-SPEARMAN-CONTIG: Supervised substitutions, contiguous split, Spearman · ProteinGym substitution DMS assays (ProteinGym split)

Evidence origin: Author-reported evaluation.

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, column(Supervised substitutions, contiguous split, Spearman)

MSE is better when lower; every other metric here is better when higher.
Zero-shot, supervised and indel benchmarks use different protocols and assay sets, so their figures are not comparable to each other.

Comparison details and limitations

Every method ProteinGym reports on Supervised substitutions, contiguous split, Spearman, scored with Spearman on ProteinGym substitution DMS assays.

Author-reported numbers, source checked but not independently reproduced.

Automated source review: 2026-09-18. Numerical source review does not establish independent reproduction.

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Tested configuration

-1-0.500.51

Reported score

Methods and evaluation design

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Evaluation design

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Benchmarks

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Evidence

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Evidence table

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statement	Original source and location	Review and provenance
Relationship: part of discovery-benchmark-proteingym Individual claims	ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design Original source ↗ Table 3, column(Supervised substitutions, contiguous split, Spearman) Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256 Retrieved: 2026-09-17T08:06:28.522924+00:00	source checked automated source review · 2026-09-18 Audit details Primary-source transcription with no human sign-off and no independent reproduction. Field: `links:part_of:discovery-benchmark-proteingym` Claim: proteingym-association-sup-sub-spearman-contig Source artifact SHA-256: `a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104` Hash scope: Exact retrieved primary paper artifact bytes. Inspected artifact

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Sources and history

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Release 2026-09-29-06401fd5b220 · Record review: source checked

1 source records and release history

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256

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Technical metadata and extraction receipts

Stable ID: proteingym-task-sup-sub-spearman-contig

areas: proteins-complexes
tasks: Supervised substitutions, contiguous split, Spearman
metric: Spearman
metric direction: higher
dataset: ProteinGym substitution DMS assays
protocol: Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits.
source locator: Table 3, column(Supervised substitutions, contiguous split, Spearman)
comparison panels: id: proteingym-panel-sup-sub-spearman-contig; title: ProteinGym SUP-SUB-SPEARMAN-CONTIG: Supervised substitutions, contiguous split, Spearman; protocol id: proteingym-task-sup-sub-spearman-contig; dataset id: proteingym-dataset-proteingym-substitution-dms-assays; metric: spearman; unit: correlation; direction: higher; result ids: proteingym-result-ohe-none-sup-sub-spearman-contig-spearman; proteingym-result-ohe-deepsequence-sup-sub-spearman-contig-spearman; proteingym-result-ohe-esm-1v-sup-sub-spearman-contig-spearman; proteingym-result-ohe-msat-sup-sub-spearman-contig-spearman; proteingym-result-ohe-tranception-sup-sub-spearman-contig-spearman; proteingym-result-ohe-trancepteve-sup-sub-spearman-contig-spearman; proteingym-result-embed-esm-1v-sup-sub-spearman-contig-spearman; proteingym-result-embed-msat-sup-sub-spearman-contig-spearman; proteingym-result-embed-tranception-sup-sub-spearman-contig-spearman; proteingym-result-npt-proteinnpt-sup-sub-spearman-contig-spearman; source ids: evidence-expansion-proteingym-a3b08cc4; source locator: Table 3, column(Supervised substitutions, contiguous split, Spearman); context: Every method ProteinGym reports on Supervised substitutions, contiguous split, Spearman, scored with Spearman on ProteinGym substitution DMS assays.; caveats: Author-reported numbers, source checked but not independently reproduced.; MSE is better when lower; every other metric here is better when higher.; Zero-shot, supervised and indel benchmarks use different protocols and assay sets, so their figures are not comparable to each other.; review: method: automated_source_review; date: 2026-09-18

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