OHE ESM-1v | configuration

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Evaluations and results

4 evaluations · 8 results. Different protocols are not a single leaderboard.

Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)

Sorted by MSE (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	MSE	Spearman
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-MSE-RAND: Supervised substitutions, random split, MSE	0.764 (best in column)	Not reported
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-MSE-AVG: Supervised substitutions, average over splits, MSE	0.897	Not reported
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-MSE-MOD: Supervised substitutions, modulo split, MSE	0.949	Not reported
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-MSE-CONTIG: Supervised substitutions, contiguous split, MSE	0.977	Not reported
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-SPEARMAN-AVG: Supervised substitutions, average over splits, Spearman	Not reported	0.417
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-SPEARMAN-CONTIG: Supervised substitutions, contiguous split, Spearman	Not reported	0.367
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-SPEARMAN-MOD: Supervised substitutions, modulo split, Spearman	Not reported	0.368
OHE ESM-1vEvaluation	ProteinGym SUP-SUB-SPEARMAN-RAND: Supervised substitutions, random split, Spearman	Not reported	0.514 (best in column)

All 8 result rows with coverage, uncertainty and sources

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-MSE-AVG: Supervised substitutions, average over splits, MSE Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.897 MSE unit-unreported · lower Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-MSE-AVG: Supervised substitutions, average over splits, MSE Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, average over splits, MSE)
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-MSE-CONTIG: Supervised substitutions, contiguous split, MSE Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.977 MSE unit-unreported · lower Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-MSE-CONTIG: Supervised substitutions, contiguous split, MSE Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, contiguous split, MSE)
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-MSE-MOD: Supervised substitutions, modulo split, MSE Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.949 MSE unit-unreported · lower Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-MSE-MOD: Supervised substitutions, modulo split, MSE Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, modulo split, MSE)
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-MSE-RAND: Supervised substitutions, random split, MSE Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.764 MSE unit-unreported · lower Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-MSE-RAND: Supervised substitutions, random split, MSE Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, random split, MSE)
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-SPEARMAN-AVG: Supervised substitutions, average over splits, Spearman Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.417 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-SPEARMAN-AVG: Supervised substitutions, average over splits, Spearman Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, average over splits, Spearman)
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-SPEARMAN-CONTIG: Supervised substitutions, contiguous split, Spearman Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.367 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-SPEARMAN-CONTIG: Supervised substitutions, contiguous split, Spearman Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, contiguous split, Spearman)
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-SPEARMAN-MOD: Supervised substitutions, modulo split, Spearman Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.368 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-SPEARMAN-MOD: Supervised substitutions, modulo split, Spearman Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, modulo split, Spearman)
Configuration: OHE ESM-1v	Task: ProteinGym SUP-SUB-SPEARMAN-RAND: Supervised substitutions, random split, Spearman Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)	0.514 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OHE ESM-1v on ProteinGym SUP-SUB-SPEARMAN-RAND: Supervised substitutions, random split, Spearman Supervised fitness prediction under three cross-validation schemes: contiguous, modulo and random splits. Aggregation: Not reported ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 3, row(ESM-1v), column(Supervised substitutions, random split, Spearman)

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

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Underlying model: ESM-1v. Results on this page belong to this configuration and its evaluated settings.

Evidence

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Evidence table

Inspect claims, sources and review details

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Relationship: uses model discovery-model-esm-1v Individual claims	ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design Original source ↗ Section 4.2 Supervised benchmarks, Baselines; Table 3 Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256 Retrieved: 2026-09-17T08:06:28.522924+00:00	source checked ["automated-source-review"] · 2026-09-23 Audit details Source review establishes this relationship only. Exact evaluated configurations and original numerical review status remain unchanged. These supervised estimators consume ESM-1v predictions and/or embeddings alongside other features. The full estimator uses ESM-1v; it is not identical to ESM-1v. Field: `links:uses_model:discovery-model-esm-1v` Claim: model-evaluation-identity-19d7e0f845794e184f14 Source artifact SHA-256: `a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104` Hash scope: Exact retrieved primary paper artifact bytes. Inspected artifact

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Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

1 source record and release history

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256

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Technical metadata and extraction receipts

Stable ID: proteingym-method-ohe-esm-1v

areas: proteins-complexes
source locator: Table 3, row(ESM-1v)
missing metadata: checkpoint revision: reason: unreported; parameters: reason: unextracted
provenance note: Supervised fitness predictor evaluated by the ProteinGym authors. The leading term is the input representation the paper's model type column gives.

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