Analyzing Genomic Foundation Models for Viral Sequence Identification
bioRxiv v1, posted 2026-09-28 · Preprint
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- model_characteristics: gfm2-20261011-buzkova2026-config-dnabert-2-mean-all: Model characteristics DNABERT-2: 117M parameters; context 512; flex.; tokenizer BPE (4,096); training data 135-species genomes (Table 2, row 'DNABERT-2')
- model_characteristics: gfm2-20261011-buzkova2026-config-dnabert-s-mean-all: Model characteristics DNABERT-S: 117M parameters; context 512; flex.; tokenizer BPE (4,096); training data 135-species genomes (Table 2, row 'DNABERT-S')
- model_characteristics: gfm2-20261011-buzkova2026-config-ntv1-mean-all: Model characteristics NTv1 (Multispecies 2.5B): 2.5B parameters; context 1,000; tokenizer 6-mer; training data 850-species genomes (Table 2, row 'NTv1 (Multispecies 2.5B)')
- model_characteristics: gfm2-20261011-buzkova2026-config-ntv2-50m-mean-all: Model characteristics NTv2-50M: 50M parameters; context 2,048; tokenizer 6-mer; training data 850-species genomes (Table 2, row 'NTv2-50M')
- model_characteristics: gfm2-20261011-buzkova2026-config-ntv2-250m-mean-all: Model characteristics NTv2-250M: 250M parameters; context 2,048; tokenizer 6-mer; training data 850-species genomes (Table 2, row 'NTv2-250M')
- model_characteristics: gfm2-20261011-buzkova2026-config-ntv2-500m-mean-all: Model characteristics NTv2-500M: 500M parameters; context 2,048; tokenizer 6-mer; training data 850-species genomes (Table 2, row 'NTv2-500M')
- model_characteristics: gfm2-20261011-buzkova2026-config-ntv3-8m-mean-all: Model characteristics NTv3-8M: 8M parameters; context 1 Mb; tokenizer Single-base; training data OpenGenome2 (Table 2, row 'NTv3-8M')
- model_characteristics: gfm2-20261011-buzkova2026-config-ntv3-100m-mean-all: Model characteristics NTv3-100M: 100M parameters; context 1 Mb; tokenizer Single-base; training data OpenGenome2 (Table 2, row 'NTv3-100M')
- model_characteristics: gfm2-20261011-buzkova2026-config-ntv3-650m-mean-all: Model characteristics NTv3-650M: 650M parameters; context 1 Mb; tokenizer Single-base; training data OpenGenome2 (Table 2, row 'NTv3-650M')
Models, benchmarks and other records
Models (1)
Configurations (42)
- BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)
- BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)
- DNABERT-2, frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-2, frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-2, frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-2, frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-2, frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-2, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)
- DNABERT-S, frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-S, frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-S, frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-S, frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)
- DNABERT-S, frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- NTv1 (Multispecies 2.5B), frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)
- NTv1 (Multispecies 2.5B), frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)
- NTv1 (Multispecies 2.5B), frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- NTv1 (Multispecies 2.5B), frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)
- NTv1 (Multispecies 2.5B), frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- NTv2-50M, frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)
- NTv2-50M, frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)
- NTv2-50M, frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- NTv2-50M, frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)
- NTv2-50M, frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)
- NTv2-50M, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)
- NTv2-250M, frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)
Protocols (3)
- RVDB 33-class viral classification by nearest-neighbour retrieval over frozen embeddings (Bůžková et al. 2026 Table 3)
- RVDB long-sequence viral classification, 16 classes (Bůžková et al. 2026 Table 10)
- RVDB viral classification: best frozen-embedding configuration against BLAST (Bůžková et al. 2026 Table 7)
Datasets (3)
Evaluations (47)
- BLAST (blastn) on the RVDB long-sequence dataset, 16 classes
- blastn on the RVDB 33-class dataset (BLAST comparison)
- blastn on the RVDB 40-class dataset (BLAST comparison)
- DNABERT-2, cls token only pooling, on the RVDB 33-class dataset
- DNABERT-2, max, all tokens pooling, on the RVDB 33-class dataset
- DNABERT-2, max, special tokens excluded pooling, on the RVDB 33-class dataset
- DNABERT-2, mean, all tokens pooling, on the RVDB 33-class dataset
- DNABERT-2, mean, special tokens excluded pooling, on the RVDB 33-class dataset
- DNABERT-2ᵃ on the RVDB long-sequence dataset, 16 classes
- DNABERT-S, cls token only pooling, on the RVDB 33-class dataset
- DNABERT-S, max, all tokens pooling, on the RVDB 33-class dataset
- DNABERT-S, max, special tokens excluded pooling, on the RVDB 33-class dataset
- DNABERT-S, mean, all tokens pooling, on the RVDB 33-class dataset
- DNABERT-S, mean, special tokens excluded pooling, on the RVDB 33-class dataset
- megablast on the RVDB 33-class dataset (BLAST comparison)
- megablast on the RVDB 40-class dataset (BLAST comparison)
- NTv1 (Multispecies 2.5B), cls token only pooling, on the RVDB 33-class dataset
- NTv1 (Multispecies 2.5B), max, all tokens pooling, on the RVDB 33-class dataset
- NTv1 (Multispecies 2.5B), max, special tokens excluded pooling, on the RVDB 33-class dataset
- NTv1 (Multispecies 2.5B), mean, all tokens pooling, on the RVDB 33-class dataset
- NTv1 (Multispecies 2.5B), mean, special tokens excluded pooling, on the RVDB 33-class dataset
- NTv2-50M, cls token only pooling, on the RVDB 33-class dataset
- NTv2-50M, max, all tokens pooling, on the RVDB 33-class dataset
- NTv2-50M, max, special tokens excluded pooling, on the RVDB 33-class dataset
- NTv2-50M, mean, all tokens pooling, on the RVDB 33-class dataset
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25 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Artifact SHA-256 9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19 Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact url https://www.biorxiv.org/content/10.64898/2026.09.25.754388v1.full.pdf Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Doi 10.64898/2026.09.25.754388 Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Licence CC-BY-4.0 Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Media type application/pdf Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Publication status preprint Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Retrieved at 2026-10-11T00:48:35Z Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Review: artifact sha256 9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19 Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Review: date 2026-10-11 Source metadata | Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Review method2 values
| Analyzing Genomic Foundation Models for Viral Sequence Identification No field-specific location recorded Version: bioRxiv v1, posted 2026-09-28 | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
bioRxiv preprint v1 comparing frozen Nucleotide Transformer and DNABERT embeddings with nearest-neighbour search against BLAST on RVDB-derived viral classification.
Technical metadata and extraction receipts
Stable ID: gfm2-20261011-buzkova2026-source
- areas
- dna-genomes
- contexts
- research
- url
- https://doi.org/10.64898/2026.09.25.754388
- doi
- 10.64898/2026.09.25.754388
- artifact url
- https://www.biorxiv.org/content/10.64898/2026.09.25.754388v1.full.pdf
- artifact sha256
- 9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19
- retrieved at
- 2026-10-11T00:48:35Z
- publication status
- preprint
- version
- bioRxiv v1, posted 2026-09-28
- licence
- CC-BY-4.0
- media type
- application/pdf
- source locator
- Full text PDF, 27 pages; Tables 1-10
- review
- method: source-hash-verification; ai-assisted-source-review; reviewer: claude; reviewer note: Claude (Opus 5.5) review agent reviewer-gfm-a, independent of the extractor lit-gfm-2; no human review claimed; date: 2026-10-11; artifact sha256: 9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19; retrieval url: https://www.biorxiv.org/content/10.64898/2026.09.25.754388v1.full.pdf; note: Archived copy matches the pinned SHA-256; licence CC BY 4.0 confirmed on the PDF banner.