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Analyzing Genomic Foundation Models for Viral Sequence Identification

bioRxiv v1, posted 2026-09-28 · Preprint

DOI: 10.64898/2026.09.25.754388

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Model or configurationMetricValueDatasetEvaluation
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Accuracy (16-class long-sequence RVDB dataset)0.9766 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesBLAST (blastn) on the RVDB long-sequence dataset, 16 classes
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Balanced accuracy (16-class long-sequence RVDB dataset)0.9766 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesBLAST (blastn) on the RVDB long-sequence dataset, 16 classes
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Macro F1 (16-class long-sequence RVDB dataset)0.9765 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesBLAST (blastn) on the RVDB long-sequence dataset, 16 classes
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)MCC (16-class long-sequence RVDB dataset)0.9751 unitlessRVDB C-RVDB v31.0 long-sequence dataset, 16 classesBLAST (blastn) on the RVDB long-sequence dataset, 16 classes
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Precision (16-class long-sequence RVDB dataset, macro-averaged over classes)0.9776 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesBLAST (blastn) on the RVDB long-sequence dataset, 16 classes
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Recall (16-class long-sequence RVDB dataset, macro-averaged over classes)0.9766 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesBLAST (blastn) on the RVDB long-sequence dataset, 16 classes
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Accuracy (33-class RVDB dataset)0.9677 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesblastn on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Macro F1 (33-class RVDB dataset)0.9379 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesblastn on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Precision (33-class RVDB dataset, macro-averaged over classes)0.9401 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesblastn on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Recall (33-class RVDB dataset, macro-averaged over classes)0.9392 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesblastn on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Accuracy (40-class RVDB dataset)0.9120 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesblastn on the RVDB 40-class dataset (BLAST comparison)
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Macro F1 (40-class RVDB dataset)0.8886 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesblastn on the RVDB 40-class dataset (BLAST comparison)
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Precision (40-class RVDB dataset, macro-averaged over classes)0.8925 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesblastn on the RVDB 40-class dataset (BLAST comparison)
BLAST 2.12.0 blastn, top hit (Bůžková et al. 2026)Recall (40-class RVDB dataset, macro-averaged over classes)0.8898 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesblastn on the RVDB 40-class dataset (BLAST comparison)
DNABERT-2, frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.7053 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-2, cls token only pooling, on the RVDB 33-class dataset
DNABERT-2, frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.7198 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-2, max, all tokens pooling, on the RVDB 33-class dataset
DNABERT-2, frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.7495 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-2, max, special tokens excluded pooling, on the RVDB 33-class dataset
DNABERT-2, frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8855 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-2, mean, all tokens pooling, on the RVDB 33-class dataset
DNABERT-2, frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8848 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-2, mean, special tokens excluded pooling, on the RVDB 33-class dataset
DNABERT-2, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)Accuracy (16-class long-sequence RVDB dataset, chunk-scored)0.7864 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesDNABERT-2ᵃ on the RVDB long-sequence dataset, 16 classes
DNABERT-2, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)Balanced accuracy (16-class long-sequence RVDB dataset, chunk-scored)0.8170 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesDNABERT-2ᵃ on the RVDB long-sequence dataset, 16 classes
DNABERT-2, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)Macro F1 (16-class long-sequence RVDB dataset, chunk-scored)0.8127 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesDNABERT-2ᵃ on the RVDB long-sequence dataset, 16 classes
DNABERT-2, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)MCC (16-class long-sequence RVDB dataset, chunk-scored)0.7711 unitlessRVDB C-RVDB v31.0 long-sequence dataset, 16 classesDNABERT-2ᵃ on the RVDB long-sequence dataset, 16 classes
DNABERT-2, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)Precision (16-class long-sequence RVDB dataset, chunk-scored, macro-averaged over classes)0.8139 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesDNABERT-2ᵃ on the RVDB long-sequence dataset, 16 classes
DNABERT-2, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)Recall (16-class long-sequence RVDB dataset, chunk-scored, macro-averaged over classes)0.8170 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesDNABERT-2ᵃ on the RVDB long-sequence dataset, 16 classes
DNABERT-S, frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.7713 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-S, cls token only pooling, on the RVDB 33-class dataset
DNABERT-S, frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.7907 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-S, max, all tokens pooling, on the RVDB 33-class dataset
DNABERT-S, frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8000 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-S, max, special tokens excluded pooling, on the RVDB 33-class dataset
DNABERT-S, frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8735 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-S, mean, all tokens pooling, on the RVDB 33-class dataset
DNABERT-S, frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8733 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesDNABERT-S, mean, special tokens excluded pooling, on the RVDB 33-class dataset
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Accuracy (33-class RVDB dataset)0.8994 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesmegablast on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Macro F1 (33-class RVDB dataset)0.8989 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesmegablast on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Precision (33-class RVDB dataset, macro-averaged over classes)0.9600 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesmegablast on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Recall (33-class RVDB dataset, macro-averaged over classes)0.8729 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesmegablast on the RVDB 33-class dataset (BLAST comparison)
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Accuracy (40-class RVDB dataset)0.8490 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesmegablast on the RVDB 40-class dataset (BLAST comparison)
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Macro F1 (40-class RVDB dataset)0.8512 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesmegablast on the RVDB 40-class dataset (BLAST comparison)
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Precision (40-class RVDB dataset, macro-averaged over classes)0.9064 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesmegablast on the RVDB 40-class dataset (BLAST comparison)
BLAST 2.12.0 megablast, top hit (Bůžková et al. 2026)Recall (40-class RVDB dataset, macro-averaged over classes)0.8283 fractionRVDB C-RVDB v31.0 primary dataset, 40 sampled classesmegablast on the RVDB 40-class dataset (BLAST comparison)
NTv1 (Multispecies 2.5B), frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8655 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv1 (Multispecies 2.5B), cls token only pooling, on the RVDB 33-class dataset
NTv1 (Multispecies 2.5B), frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.9030 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv1 (Multispecies 2.5B), max, all tokens pooling, on the RVDB 33-class dataset
NTv1 (Multispecies 2.5B), frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.9028 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv1 (Multispecies 2.5B), max, special tokens excluded pooling, on the RVDB 33-class dataset
NTv1 (Multispecies 2.5B), frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.9109 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv1 (Multispecies 2.5B), mean, all tokens pooling, on the RVDB 33-class dataset
NTv1 (Multispecies 2.5B), frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.9097 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv1 (Multispecies 2.5B), mean, special tokens excluded pooling, on the RVDB 33-class dataset
NTv2-50M, frozen embeddings, cls token only pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.7584 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv2-50M, cls token only pooling, on the RVDB 33-class dataset
NTv2-50M, frozen embeddings, max, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8673 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv2-50M, max, all tokens pooling, on the RVDB 33-class dataset
NTv2-50M, frozen embeddings, max, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.8667 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv2-50M, max, special tokens excluded pooling, on the RVDB 33-class dataset
NTv2-50M, frozen embeddings, mean, all tokens pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.9133 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv2-50M, mean, all tokens pooling, on the RVDB 33-class dataset
NTv2-50M, frozen embeddings, mean, special tokens excluded pooling, 1-NN (Bůžková et al. 2026)Accuracy (33-class RVDB dataset, 1-NN over frozen embeddings)0.9127 fractionRVDB C-RVDB v31.0 primary dataset, 33 refined classesNTv2-50M, mean, special tokens excluded pooling, on the RVDB 33-class dataset
NTv2-50M, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)Accuracy (16-class long-sequence RVDB dataset, chunk-scored)0.8532 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesNTv2-50Mᵃ on the RVDB long-sequence dataset, 16 classes
NTv2-50M, frozen embeddings, pooling not stated, 1-NN, long-sequence run (Bůžková et al. 2026)Balanced accuracy (16-class long-sequence RVDB dataset, chunk-scored)0.8699 fractionRVDB C-RVDB v31.0 long-sequence dataset, 16 classesNTv2-50Mᵃ on the RVDB long-sequence dataset, 16 classes

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Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
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9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19
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Analyzing Genomic Foundation Models for Viral Sequence Identification

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Analyzing Genomic Foundation Models for Viral Sequence Identification

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10.64898/2026.09.25.754388
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Analyzing Genomic Foundation Models for Viral Sequence Identification

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Analyzing Genomic Foundation Models for Viral Sequence Identification

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Analyzing Genomic Foundation Models for Viral Sequence Identification

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Analyzing Genomic Foundation Models for Viral Sequence Identification

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9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19
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Analyzing Genomic Foundation Models for Viral Sequence Identification

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2026-10-11
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Analyzing Genomic Foundation Models for Viral Sequence Identification

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Analyzing Genomic Foundation Models for Viral Sequence Identification

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Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

bioRxiv preprint v1 comparing frozen Nucleotide Transformer and DNABERT embeddings with nearest-neighbour search against BLAST on RVDB-derived viral classification.

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Stable ID: gfm2-20261011-buzkova2026-source

areas
dna-genomes
contexts
research
url
https://doi.org/10.64898/2026.09.25.754388
doi
10.64898/2026.09.25.754388
artifact url
https://www.biorxiv.org/content/10.64898/2026.09.25.754388v1.full.pdf
artifact sha256
9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19
retrieved at
2026-10-11T00:48:35Z
publication status
preprint
version
bioRxiv v1, posted 2026-09-28
licence
CC-BY-4.0
media type
application/pdf
source locator
Full text PDF, 27 pages; Tables 1-10
review
method: source-hash-verification; ai-assisted-source-review; reviewer: claude; reviewer note: Claude (Opus 5.5) review agent reviewer-gfm-a, independent of the extractor lit-gfm-2; no human review claimed; date: 2026-10-11; artifact sha256: 9a589a2088f8466502b1035228db3e594065e984e5755c25d907471225f75c19; retrieval url: https://www.biorxiv.org/content/10.64898/2026.09.25.754388v1.full.pdf; note: Archived copy matches the pinned SHA-256; licence CC BY 4.0 confirmed on the PDF banner.
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