Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024)
Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text · Peer-reviewed
What this source contributed
Records in this release that cite this source. A record can cite several sources.
Results
Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.
| Value | Metric | Model or configuration | Dataset | Evaluation |
|---|---|---|---|---|
| 11 count | Count (generated designs active in vitro, out of 24 tested; IS200-like family) | Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | Evo-generated IS200-like designs, in vitro activity (Nguyen et al. 2024) |
| 3 count | Count (generated designs active in vitro, out of 24 tested; IS605-like family) | Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | Evo-generated IS605-like designs, in vitro activity (Nguyen et al. 2024) |
Claims
Statements this source supports, each with where in the source it was checked.
- Evo paper: 11 generated Cas9-family designs tested, one active: Generated cas9 designs tested 11 generated Cas9-family designs selected and tested; the source states that one of them showed robust activity (Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations'))
Models, benchmarks and other records
Configurations (1)
Protocols (1)
Datasets (1)
Evaluations (2)
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
28 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.artifact_sha256 6bf1e0563c2870088e9c6c46361052fd0e9418c3122ee29aa4a2373794e65caa Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Artifact url https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&id=12057570 Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Doi 10.1126/science.ado9336 Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Hash scope SHA-256 of the retrieved efetch JATS XML bytes Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Licence Science journal article reuse terms (licence statement: 'No claim to original US government works'); not an open licence Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
Limitations4 values
| Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Media type application/xml Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Publication status peer_reviewed Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Retrieved at 2026-10-14T12:12:36Z Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| attributes.review.artifact_sha256 6bf1e0563c2870088e9c6c46361052fd0e9418c3122ee29aa4a2373794e65caa Source metadata | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) No field-specific location recorded Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Primary source retrieved and hashed for the issue #129 Evo generation evidence pass.
1 source record and release history
- Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Original source · Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-evo-generation-source-article
- areas
- dna-genomes
- contexts
- research
- url
- https://doi.org/10.1126/science.ado9336
- artifact url
- https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&id=12057570
- version
- Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text
- retrieved at
- 2026-10-14T12:12:36Z
- artifact sha256
- 6bf1e0563c2870088e9c6c46361052fd0e9418c3122ee29aa4a2373794e65caa
- doi
- 10.1126/science.ado9336
- publication status
- peer_reviewed
- media type
- application/xml
- hash scope
- SHA-256 of the retrieved efetch JATS XML bytes
- licence
- Science journal article reuse terms (licence statement: 'No claim to original US government works'); not an open licence
- source locator
- Results and Materials and methods of the author manuscript full text
- limitations
- PubMed Central author manuscript, not the publisher's typeset article; wording and figure numbering follow the accepted manuscript.; The supplementary material could not be retrieved: the Science supplement URL returned HTTP 403 and Europe PMC reports PMC12057570 as not open access, so the supplementary tables and figures were not checked.; Quantitative generation metrics in this paper are figures (generated-sequence coding density, protein pLDDT and identity distributions, tetranucleotide usage deviations, stop-codon frequencies, perplexity scaling). No printed numbers for them, so they are not extracted.; The in vitro counts extracted here are a wet-lab outcome for a selected, filtered subset of generated designs, not a benchmark score on a held-out dataset; the selection pipeline is a filter chosen by the authors.
- review
- method: source-hash-verification; method note: Re-downloaded on 2026-10-14; SHA-256 matches.; reviewer: claude; reviewer note: Claude (Opus 5.5) research agent, independent of the extractor; no human review claimed; date: 2026-10-14; artifact sha256: 6bf1e0563c2870088e9c6c46361052fd0e9418c3122ee29aa4a2373794e65caa; retrieval url: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&id=12057570; note: Independent review 2026-10-14.