In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024)
Count of tested generated designs that showed the assayed activity in vitro, reported separately for the two element families.
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
2 recorded evaluations, 2 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.
Results
Results are available, but no reviewed comparison panel is linked in this release.
All evaluations
2 evaluations · 2 results. Different protocols are not a single leaderboard.
Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) · Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024)
Sorted by Count (generated designs active in vitro, out of 24 tested; IS200-like family) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Count (generated designs active in vitro, out of 24 tested; IS200-like family) | Count (generated designs active in vitro, out of 24 tested; IS605-like family) |
|---|---|---|
| Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024)Evaluation | 11 | Not reported |
| Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024)Evaluation | Not reported | 3 |
All 2 result rows with coverage, uncertainty and sources
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | 11 Count (generated designs active in vitro, out of 24 tested; IS200-like family) count · higher Uncertainty: Not applicable: A single count of a binary assay outcome; no spread printed Coverage: 24/24 designs scored (All 24 selected designs of the family were tested; the number of generations the 24 were selected from is not printed.) | Author-reported evaluation · Source checkedMethods, coverage and sourceEvo-generated IS200-like designs, in vitro activity (Nguyen et al. 2024) gfm-guides-20261014-evo-generation-protocol-in-vitro-activity Aggregation: Not reported Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Results, section 'Generative design of transposon systems', sentence beginning 'We observed that 11 out of 24': '11 out of 24 Evo-generated IS200-like elements' |
| Configuration: Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | 3 Count (generated designs active in vitro, out of 24 tested; IS605-like family) count · higher Uncertainty: Not applicable: A single count of a binary assay outcome; no spread printed Coverage: 24/24 designs scored (All 24 selected designs of the family were tested; the number of generations the 24 were selected from is not printed.) | Author-reported evaluation · Source checkedMethods, coverage and sourceEvo-generated IS605-like designs, in vitro activity (Nguyen et al. 2024) gfm-guides-20261014-evo-generation-protocol-in-vitro-activity Aggregation: Not reported Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Results, section 'Generative design of transposon systems', sentence beginning 'We observed that 11 out of 24': '3 out of 24 Evo-generated IS605-like elements' |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
Methods and evaluation design
Procedure, tasks and evaluated configurations
Recorded evaluations
Each evaluation records what was tested and under which conditions.
Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.
No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.
- Author-reported evaluations
- 2
Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.
Null control
Proposed control: requires review
Select a task-valid null control after reviewing inputs and metric
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Conventional reference
Proposed control: requires review
Select an upstream conventional reference after reviewing the full protocol
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run instructions
No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
0 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|
No evidence rows match these filters. Choose another scope or clear the search.
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Original source · Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-evo-generation-protocol-in-vitro-activity
- areas
- dna-genomes
- contexts
- research
- protocol
- Each selected design is tested in an in vitro assay and scored as active or not; the source reports the number of active designs out of the 24 tested per element family.
- version
- As published, Science 386, eado9336 (2024)
- metric
- count
- metric direction
- higher
- metric definition
- Number of tested designs scored active in the assay
- source locator
- Results, section 'Generative design of transposon systems' (sentence beginning 'We observed that 11 out of 24'); Fig. 4E to J and fig. S21
- limitations
- Denominator is the 24 designs selected per family, not all generations; the filter is described qualitatively.; Binary active or inactive scoring; no replicate count, uncertainty or activity level is printed.; A single assay format per family; the source also reports control tests of natural elements, which are not counts over designs and are not extracted.; Figures 4E to J and fig. S21 carry the per-design evidence; no per-design table of outcomes is printed.