Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024)
Evo fine-tuned on mobile-element loci and prompted with family tokens to generate candidate designs.
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Evaluations and results
2 evaluations · 2 results. Different protocols are not a single leaderboard.
Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) · Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024)
Sorted by Count (generated designs active in vitro, out of 24 tested; IS200-like family) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Count (generated designs active in vitro, out of 24 tested; IS200-like family) | Count (generated designs active in vitro, out of 24 tested; IS605-like family) |
|---|---|---|
| Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024)Evaluation | 11 | Not reported |
| Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024)Evaluation | Not reported | 3 |
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | 11 Count (generated designs active in vitro, out of 24 tested; IS200-like family) count · higher Uncertainty: Not applicable: A single count of a binary assay outcome; no spread printed Coverage: 24/24 designs scored (All 24 selected designs of the family were tested; the number of generations the 24 were selected from is not printed.) | Author-reported evaluation · Source checkedMethods, coverage and sourceEvo-generated IS200-like designs, in vitro activity (Nguyen et al. 2024) gfm-guides-20261014-evo-generation-protocol-in-vitro-activity Aggregation: Not reported Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Results, section 'Generative design of transposon systems', sentence beginning 'We observed that 11 out of 24': '11 out of 24 Evo-generated IS200-like elements' |
| Configuration: Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | 3 Count (generated designs active in vitro, out of 24 tested; IS605-like family) count · higher Uncertainty: Not applicable: A single count of a binary assay outcome; no spread printed Coverage: 24/24 designs scored (All 24 selected designs of the family were tested; the number of generations the 24 were selected from is not printed.) | Author-reported evaluation · Source checkedMethods, coverage and sourceEvo-generated IS605-like designs, in vitro activity (Nguyen et al. 2024) gfm-guides-20261014-evo-generation-protocol-in-vitro-activity Aggregation: Not reported Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Results, section 'Generative design of transposon systems', sentence beginning 'We observed that 11 out of 24': '3 out of 24 Evo-generated IS605-like elements' |
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Original source · Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-evo-generation-config-evo-finetuned-is200-is605
- areas
- dna-genomes
- contexts
- research
- method types
- foundation_model
- reported name
- Evo
- foundation model eligible
- true
- parameters
- 7B parameters, 131,072-token context base model; fine-tuned on 10,720 IS605 and 219,866 IS200 elements in their natural sequence context, with family prompt tokens
- access reuse
- Model weights and code released by the authors (Data and code availability)
- source locator
- Results, section 'Generative design of transposon systems'; Materials and methods
- missing metadata
- checkpoint revision: reason: unreported; version: reason: unreported; note: The fine-tuned checkpoint is not given a version in the text