Evo paper: 11 generated Cas9-family designs tested, one active
Generated cas9 designs tested of Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024)
11 generated Cas9-family designs selected and tested; the source states that one of them showed robust activity
The source states that 11 generated Cas9-family designs were selected and tested, and that one showed activity. The active count is printed as a word, not a numeral, so it is recorded as a claim rather than a result.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field generated_cas9_designs_tested Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations') Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Source location Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations') Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations') Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Claimed value 11 generated Cas9-family designs selected and tested; the source states that one of them showed robust activity Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations') Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Description The source states that 11 generated Cas9-family designs were selected and tested, and that one showed activity. The active count is printed as a word, not a numeral, so it is recorded as a claim rather than a result. Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations') Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Relationship: subject gfm-guides-20261014-evo-generation-config-evo-finetuned-is200-is605 Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations') Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Name Evo paper: 11 generated Cas9-family designs tested, one active Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations') Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Original source · Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-evo-generation-claim-cas9-designs-tested
- field
- generated_cas9_designs_tested
- value
- 11 generated Cas9-family designs selected and tested; the source states that one of them showed robust activity
- source locator
- Results, section 'Generative design of CRISPR-Cas molecular complexes' (sentences beginning 'Next, we filtered' and 'We evaluated the 11 Cas9 generations')
- review
- method: source-hash-verification; transcription; scope-review; method note: PMC JATS re-downloaded on 2026-10-14 (SHA-256 matches); the sentences re-read verbatim.; reviewer: claude; reviewer note: Claude (Opus 5.5) research agent, independent of the extractor; no human review claimed; date: 2026-10-14; artifact sha256: 6bf1e0563c2870088e9c6c46361052fd0e9418c3122ee29aa4a2373794e65caa; retrieval url: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&id=12057570; note: Extraction: Transcribed by hand from the pinned JATS full text; the extraction script asserts the exact sentence and the sentence stating the 24 designs tested per family before writing the records. Independent review 2026-10-14: matched. For the transposon results, 'active' means the source's 'evidence for both excision and insertion in vitro'. Kept in the catalogue as an author-selected laboratory outcome; see the protocol limitations.