48 sequences generated by the fine-tuned Evo model and selected for laboratory testing: 24 IS200-like and 24 IS605-like designs.
2 evaluations · 2 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | 11 Count (generated designs active in vitro, out of 24 tested; IS200-like family) count · higher Uncertainty: Not applicable: A single count of a binary assay outcome; no spread printed Coverage: 24/24 designs scored (All 24 selected designs of the family were tested; the number of generations the 24 were selected from is not printed.) | Author-reported evaluation · Source checkedMethods, coverage and sourceEvo-generated IS200-like designs, in vitro activity (Nguyen et al. 2024) gfm-guides-20261014-evo-generation-protocol-in-vitro-activity Aggregation: Not reported Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Results, section 'Generative design of transposon systems', sentence beginning 'We observed that 11 out of 24': '11 out of 24 Evo-generated IS200-like elements' |
| Configuration: Evo fine-tuned on IS200/IS605 elements (Nguyen et al. 2024) | Protocol: In vitro activity of Evo-generated mobile-element designs (Nguyen et al. 2024) Dataset: Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) | 3 Count (generated designs active in vitro, out of 24 tested; IS605-like family) count · higher Uncertainty: Not applicable: A single count of a binary assay outcome; no spread printed Coverage: 24/24 designs scored (All 24 selected designs of the family were tested; the number of generations the 24 were selected from is not printed.) | Author-reported evaluation · Source checkedMethods, coverage and sourceEvo-generated IS605-like designs, in vitro activity (Nguyen et al. 2024) gfm-guides-20261014-evo-generation-protocol-in-vitro-activity Aggregation: Not reported Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) · Results, section 'Generative design of transposon systems', sentence beginning 'We observed that 11 out of 24': '3 out of 24 Evo-generated IS605-like elements' |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.
Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified
Exact outcomes, predictions, identifiers and evaluator are connected.
Missing or unresolved evidence
Verified: Not verified
Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.
Missing or unresolved evidence
Verified: Not verified
A pinned recipe describes the inputs, environment and resource requirements.
Missing or unresolved evidence
Verified: Not verified
Separate data and exposure records support an independent test.
Missing or unresolved evidence
Verified: Not verified
Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.
No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.
A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
7 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Population 24 IS200-like designs and 24 IS605-like designs, selected from the model's generations by similarity to four natural elements and by protein-level and DNA-level sequence filters Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of transposon systems'; Materials and methods Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Source location Results, section 'Generative design of transposon systems'; Materials and methods Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of transposon systems'; Materials and methods Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Split No split; the tested designs are the selected generations Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of transposon systems'; Materials and methods Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Total 48 Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of transposon systems'; Materials and methods Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Version As published, Science 386, eado9336 (2024) Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of transposon systems'; Materials and methods Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Description 48 sequences generated by the fine-tuned Evo model and selected for laboratory testing: 24 IS200-like and 24 IS605-like designs. Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of transposon systems'; Materials and methods Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
| Name Evo-generated IS200-like and IS605-like designs selected for in vitro testing (Nguyen et al. 2024) Context-only references | Sequence modeling and design from molecular to genome scale with Evo (Nguyen et al., Science 2024) Results, section 'Generative design of transposon systems'; Materials and methods Version: Science 386, eado9336 (15 November 2024); PubMed Central author manuscript PMC12057570, PMC version 1, JATS full text | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the retrieved efetch JATS XML bytes |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: gfm-guides-20261014-evo-generation-data-generated-is-designs