rewirebio.iobenchmarks
Dataset

CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever

One short-read metagenome provided with a modified case report; causal pathogen Crimean-Congo haemorrhagic fever orthonairovirus (CCHFV).

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-09-8cc1db47c7f9 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

8 evaluations · 16 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: CCMetagen v1.1.3 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
yes success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

CCMetagen v1.1.3: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B12, row 'CCMetagen v1.1.3', column 'Causal pathogen in submitted list of taxa'
Configuration: CCMetagen v1.1.3 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
yes success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

CCMetagen v1.1.3: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C12, row 'CCMetagen v1.1.3', column 'Predicted causal pathogen'
Configuration: LSHVec (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

LSHVec: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B5, row 'LSHVec', column 'Causal pathogen in submitted list of taxa'
Configuration: LSHVec (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

LSHVec: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C5, row 'LSHVec', column 'Predicted causal pathogen'
Configuration: MetaPhlAn v2.2.0 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
yes success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

MetaPhlAn v2.2.0: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B6, row 'MetaPhlAn v2.2.0', column 'Causal pathogen in submitted list of taxa'
Configuration: MetaPhlAn v2.2.0 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
yes success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

MetaPhlAn v2.2.0: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C6, row 'MetaPhlAn v2.2.0', column 'Predicted causal pathogen'
Configuration: MetaPhlAn v2.9.14 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

MetaPhlAn v2.9.14: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B7, row 'MetaPhlAn v2.9.14', column 'Causal pathogen in submitted list of taxa'
Configuration: MetaPhlAn v2.9.14 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

MetaPhlAn v2.9.14: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C7, row 'MetaPhlAn v2.9.14', column 'Predicted causal pathogen'
Configuration: MetaPhyler v1.25 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

MetaPhyler v1.25: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B8, row 'MetaPhyler v1.25', column 'Causal pathogen in submitted list of taxa'
Configuration: MetaPhyler v1.25 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

MetaPhyler v1.25: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C8, row 'MetaPhyler v1.25', column 'Predicted causal pathogen'
Configuration: NSSAC (assembly) (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

NSSAC (assembly): CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B10, row 'NSSAC (assembly)', column 'Causal pathogen in submitted list of taxa'
Configuration: NSSAC (assembly) (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

NSSAC (assembly): CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C10, row 'NSSAC (assembly)', column 'Predicted causal pathogen'
Configuration: NSSAC (full genome) (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

NSSAC (full genome): CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B9, row 'NSSAC (full genome)', column 'Causal pathogen in submitted list of taxa'
Configuration: NSSAC (full genome) (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

NSSAC (full genome): CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C9, row 'NSSAC (full genome)', column 'Predicted causal pathogen'
Configuration: Pathoscope v2.0.7 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

Pathoscope v2.0.7: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell B11, row 'Pathoscope v2.0.7', column 'Causal pathogen in submitted list of taxa'
Configuration: Pathoscope v2.0.7 (CAMI II pathogen challenge submission)Protocol: Identify all pathogens and the causal pathogen in one clinical blood metagenome (CAMI II clinical pathogen challenge)
Dataset: CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
no success-rate
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

Pathoscope v2.0.7: CAMI II clinical pathogen challenge

rna-pathogen-20261009-protocol-meyer2022-causal-pathogen

Aggregation: Not reported

Meyer et al. 2022, Supplementary Tables 1-40 · Supplementary Table 39 cell C11, row 'Pathoscope v2.0.7', column 'Predicted causal pathogen'

Source checking is not independent reproduction. Release 2026-10-09-8cc1db47c7f9.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-8cc1db47c7f9
Property and statementOriginal source and locationReview and provenance
attributes.denominator
1
Context-only references
Critical Assessment of Metagenome Interpretation: the second round of challenges

Original source ↗

Methods 'Challenge datasets' paragraph 5

Version: Nature Methods 19(4):429, published 2022-04-08; PMC9007738 full-text XML
Retrieved: 2026-10-09T20:21:44Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.denominator

Source artifact SHA-256: 2532db9c9abd1f040047afdcc859cb83739a9cceb4dbd998cd550017da9bd7ba

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population
One blood sample; CCHFV sequences previously found and confirmed by PCR (Ct 27.4); human reads replaced by reads from the same regions of the 1000 Genomes data.
Context-only references
Critical Assessment of Metagenome Interpretation: the second round of challenges

Original source ↗

Methods 'Challenge datasets' paragraph 5

Version: Nature Methods 19(4):429, published 2022-04-08; PMC9007738 full-text XML
Retrieved: 2026-10-09T20:21:44Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population

Source artifact SHA-256: 2532db9c9abd1f040047afdcc859cb83739a9cceb4dbd998cd550017da9bd7ba

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.source_locator
Methods 'Challenge datasets' paragraph 5
Context-only references
Critical Assessment of Metagenome Interpretation: the second round of challenges

Original source ↗

Methods 'Challenge datasets' paragraph 5

Version: Nature Methods 19(4):429, published 2022-04-08; PMC9007738 full-text XML
Retrieved: 2026-10-09T20:21:44Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: 2532db9c9abd1f040047afdcc859cb83739a9cceb4dbd998cd550017da9bd7ba

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.split
Single sample
Context-only references
Critical Assessment of Metagenome Interpretation: the second round of challenges

Original source ↗

Methods 'Challenge datasets' paragraph 5

Version: Nature Methods 19(4):429, published 2022-04-08; PMC9007738 full-text XML
Retrieved: 2026-10-09T20:21:44Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.split

Source artifact SHA-256: 2532db9c9abd1f040047afdcc859cb83739a9cceb4dbd998cd550017da9bd7ba

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.version
CAMI II pathogen challenge dataset (688 MB paired-end MiSeq)
Context-only references
Critical Assessment of Metagenome Interpretation: the second round of challenges

Original source ↗

Methods 'Challenge datasets' paragraph 5

Version: Nature Methods 19(4):429, published 2022-04-08; PMC9007738 full-text XML
Retrieved: 2026-10-09T20:21:44Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.version

Source artifact SHA-256: 2532db9c9abd1f040047afdcc859cb83739a9cceb4dbd998cd550017da9bd7ba

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

description
One short-read metagenome provided with a modified case report; causal pathogen Crimean-Congo haemorrhagic fever orthonairovirus (CCHFV).
Context-only references
Critical Assessment of Metagenome Interpretation: the second round of challenges

Original source ↗

Methods 'Challenge datasets' paragraph 5

Version: Nature Methods 19(4):429, published 2022-04-08; PMC9007738 full-text XML
Retrieved: 2026-10-09T20:21:44Z

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: 2532db9c9abd1f040047afdcc859cb83739a9cceb4dbd998cd550017da9bd7ba

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

name
CAMI II clinical pathogen challenge: blood metagenome from a patient with haemorrhagic fever
Context-only references
Critical Assessment of Metagenome Interpretation: the second round of challenges

Original source ↗

Methods 'Challenge datasets' paragraph 5

Version: Nature Methods 19(4):429, published 2022-04-08; PMC9007738 full-text XML
Retrieved: 2026-10-09T20:21:44Z

not individually reviewed

No individual claim review recorded

Audit details

Field: name

Source artifact SHA-256: 2532db9c9abd1f040047afdcc859cb83739a9cceb4dbd998cd550017da9bd7ba

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-09-8cc1db47c7f9 · Record review: source checked

1 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: rna-pathogen-20261009-data-meyer2022-cami2-clinical-pathogen

areas
microbes-communities
contexts
clinical_research
version
CAMI II pathogen challenge dataset (688 MB paired-end MiSeq)
population
One blood sample; CCHFV sequences previously found and confirmed by PCR (Ct 27.4); human reads replaced by reads from the same regions of the 1000 Genomes data.
split
Single sample
denominator
1
source locator
Methods 'Challenge datasets' paragraph 5
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