rewirebio.iobenchmarks
Dataset

Control plasma samples without fever or infection (Wolf et al. 2026)

Prospectively collected leftover clinical plasma samples.

Evaluation results

2 evaluations · 8 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
134 True negatives (negative control samples; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days)
count · higher

Uncertainty: Not applicable: Count

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (all positive tests) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Any organism*', row 'All positive tests', column 'Negative (n=162)'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
82·7% Specificity (predictive specificity; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days)
percent · higher

Uncertainty: 95% CI 76.0 to 88.2

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (all positive tests) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Any organism*', row 'All positive tests', column 'Specificity'
Configuration: Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
147 True negatives (negative control samples; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days)
count · higher

Uncertainty: Not applicable: Count

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (post-hoc 140 molecules per microlitre cut-off) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Any organism*', row '≥140 molecules per μL†', column 'Negative (n=162)'
Configuration: Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
90·7% Specificity (predictive specificity; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days)
percent · higher

Uncertainty: 95% CI 85.2 to 94.7

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (post-hoc 140 molecules per microlitre cut-off) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Any organism*', row '≥140 molecules per μL†', column 'Specificity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
144 True negatives (negative control samples; common bloodstream infection pathogens; control samples without fever or infection within 7 days)
count · higher

Uncertainty: Not applicable: Count

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (all positive tests) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Common bloodstream infection pathogen‡', row 'All positive tests', column 'Negative (n=162)'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
88·9% Specificity (predictive specificity; common bloodstream infection pathogens; control samples without fever or infection within 7 days)
percent · higher

Uncertainty: 95% CI 83.0 to 93.3

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (all positive tests) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Common bloodstream infection pathogen‡', row 'All positive tests', column 'Specificity'
Configuration: Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
152 True negatives (negative control samples; common bloodstream infection pathogens; control samples without fever or infection within 7 days)
count · higher

Uncertainty: Not applicable: Count

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (post-hoc 140 molecules per microlitre cut-off) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Common bloodstream infection pathogen‡', row '≥140 molecules per μL†', column 'Negative (n=162)'
Configuration: Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026)Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3)
Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
93·8% Specificity (predictive specificity; common bloodstream infection pathogens; control samples without fever or infection within 7 days)
percent · higher

Uncertainty: 95% CI 88.9 to 97.0

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Karius mcfDNA-Seq (post-hoc 140 molecules per microlitre cut-off) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)

dna-pathogen-20261011-wolf2026-protocol-specificity

Aggregation: Not reported

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Common bloodstream infection pathogen‡', row '≥140 molecules per μL†', column 'Specificity'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Access
Not stated in the inspected text
Context-only references
Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study

Original source ↗

Methods 'Procedures' paragraph 1; Table 3

Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Retrieved: 2026-10-11T22:07:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.access

Source artifact SHA-256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Population
162 control samples from the same population with no fever or infection within 7 days before or after collection
Context-only references
Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study

Original source ↗

Methods 'Procedures' paragraph 1; Table 3

Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Retrieved: 2026-10-11T22:07:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population

Source artifact SHA-256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Source location
Methods 'Procedures' paragraph 1; Table 3
Context-only references
Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study

Original source ↗

Methods 'Procedures' paragraph 1; Table 3

Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Retrieved: 2026-10-11T22:07:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Split
Single prospective cohort; no split
Context-only references
Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study

Original source ↗

Methods 'Procedures' paragraph 1; Table 3

Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Retrieved: 2026-10-11T22:07:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.split

Source artifact SHA-256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Version
As described in Wolf et al. 2026 (consolidated pilot and completion phases)
Context-only references
Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study

Original source ↗

Methods 'Procedures' paragraph 1; Table 3

Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Retrieved: 2026-10-11T22:07:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.version

Source artifact SHA-256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Description
Prospectively collected leftover clinical plasma samples.
Context-only references
Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study

Original source ↗

Methods 'Procedures' paragraph 1; Table 3

Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Retrieved: 2026-10-11T22:07:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Name
Control plasma samples without fever or infection (Wolf et al. 2026)
Context-only references
Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study

Original source ↗

Methods 'Procedures' paragraph 1; Table 3

Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Retrieved: 2026-10-11T22:07:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: name

Source artifact SHA-256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: dna-pathogen-20261011-wolf2026-data-controls

areas
microbes-communities
contexts
clinical_research
version
As described in Wolf et al. 2026 (consolidated pilot and completion phases)
population
162 control samples from the same population with no fever or infection within 7 days before or after collection
split
Single prospective cohort; no split
access
Not stated in the inspected text
source locator
Methods 'Procedures' paragraph 1; Table 3
Related records

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