Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026)
Karius mcfDNA-Seq results interpreted with: post-hoc 140 molecules per microlitre cut-off.
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
1 evaluation · 4 results. Different protocols are not a single leaderboard.
Protocol: Predictive specificity in control samples (Wolf et al. 2026 Table 3) · Dataset: Control plasma samples without fever or infection (Wolf et al. 2026)
Sorted by Specificity (predictive specificity; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Specificity (predictive specificity; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days) | Specificity (predictive specificity; common bloodstream infection pathogens; control samples without fever or infection within 7 days) | True negatives (negative control samples; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days) | True negatives (negative control samples; common bloodstream infection pathogens; control samples without fever or infection within 7 days) |
|---|---|---|---|---|
| Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026)Evaluation | 90·7% | 93·8% | 147 | 152 |
All 4 result rows with coverage, uncertainty and sources
Filter evaluations
Applied filters: All linked evaluations
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
Use this configuration
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
0 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|
No evidence rows match these filters. Choose another scope or clear the search.
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Original source · The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Technical metadata and extraction receipts
Stable ID: dna-pathogen-20261011-wolf2026-config-cutoff140
- areas
- microbes-communities
- contexts
- clinical_research
- method types
- conventional_pipeline
- reported name
- Post-hoc 140 molecules per microlitre cut-off
- parameters
- Only organisms reported at 140 molecules per microlitre of plasma or higher count as positive; cut-off chosen post hoc by maximising Youden's index on the consolidated data (AUC 0.73).
- foundation model eligible
- false
- access reuse
- Commercial laboratory test; testing was provided by Karius as non-financial support
- source locator
- Methods 'Statistical analysis' paragraphs 3 and 5; Table 3 footnote
- missing metadata
- version: reason: unreported; note: No assay, pipeline or database version is given in the inspected text