True negatives (negative control samples; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days) of Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026) on Control plasma samples without fever or infection (Wolf et al. 2026)
147 True negatives (negative control samples; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days)
Methods
- Tested configuration
- Karius mcfDNA-Seq, post-hoc 140 molecules per microlitre cut-off (Wolf et al. 2026)
- Protocol
- Predictive specificity in control samples (Wolf et al. 2026 Table 3)
- Dataset
- Control plasma samples without fever or infection (Wolf et al. 2026)
- Procedure
- Predictive specificity in control samples (Wolf et al. 2026 Table 3)
- Evaluation
- Karius mcfDNA-Seq (post-hoc 140 molecules per microlitre cut-off) on Predictive specificity in control samples (Wolf et al. 2026 Table 3)
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not applicable: Count
- Evidence
- Author-reported evaluation · source checkedPredicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 3, group 'Any organism*', row '≥140 molecules per μL†', column 'Negative (n=162)'
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Single cohort
- Adaptation
- Only organisms reported at 140 molecules per microlitre of plasma or higher count as positive; cut-off chosen post hoc by maximising Youden's index on the consolidated data (AUC 0.73).
- Scoring implementation
- Proportion of evaluable control samples in which mcfDNA-Seq detected no bacterium or yeast (any organism) or no common bloodstream infection pathogen.
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 147 Individual claims | Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Table 3, group 'Any organism*', row '≥140 molecules per μL†', column 'Negative (n=162)' Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-11 author reported Audit detailsRe-downloaded the pinned artifact and matched its SHA-256; compared every value with a separate stdlib parser written for this review (the extractor's script was not run) and checked a stratified sample by hand against the rendered table. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Original source · The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)
Technical metadata and extraction receipts
Stable ID: dna-pathogen-20261011-wolf2026-result-specificity-any-cutoff140-negative
- metric
- true-negative-count
- metric direction
- higher
- unit
- count
- printed value
- 147
- numeric value
- 147
- metric qualifier
- negative control samples; any bacterium or yeast (Burkholderia, moulds, viruses and parasites excluded); control samples without fever or infection within 7 days
- source locator
- Table 3, group 'Any organism*', row '≥140 molecules per μL†', column 'Negative (n=162)'
- unit detail
- control samples
- missing metadata
- uncertainty: reason: inapplicable; note: Count
- review
- method: source-hash-verification; deterministic-table-parse; independent-cell-check; reviewer: claude; reviewer note: Separate Claude review agent (reviewer-path), independent of the extractor; no human review claimed; date: 2026-10-11; artifact sha256: 0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13154368/fullTextXML; method note: Extracted by deterministic parse of the pinned Europe PMC full-text XML (extract/extract_wolf2026.py), with row and column labels asserted. printed_value is the cell text exactly.; note: Re-downloaded the pinned artifact and matched its SHA-256; compared every value with a separate stdlib parser written for this review (the extractor's script was not run) and checked a stratified sample by hand against the rendered table.