Alternative post-hoc detection criterion (Sanderson et al. 2026)
The nanopore CMg workflow with the alternative post-hoc detection criterion.
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Evaluations and results
1 evaluation · 6 results. Different protocols are not a single leaderboard.
Protocol: Target-level detection of respiratory pathogens against routine multiplex PCR, validation set (Sanderson et al. 2026) · Dataset: Validation set: 344 prospectively collected nasopharyngeal swabs (Sanderson et al. 2026)
Sorted by Recall (all PCR targets; target level; reference: routine multiplex PCR) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Recall (all PCR targets; target level; reference: routine multiplex PCR) | Recall (RNA pathogen targets excluding rhinovirus and enterovirus; target level; reference: routine multiplex PCR) | Recall (RNA pathogen targets only (adenovirus and bacteria excluded); target level; reference: routine multiplex PCR) | Recall (targets detectable by study qPCR; target level; reference: routine multiplex PCR) | Recall (targets with study qPCR Ct < 35; target level; reference: routine multiplex PCR) | Specificity (all PCR targets; target level; reference: routine multiplex PCR) |
|---|---|---|---|---|---|---|
| Alternative post-hoc detection criterion (Sanderson et al. 2026)Evaluation | 58% | 70% | 61% | 75% | 83% | 99.9% |
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study · Original source · medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML
Technical metadata and extraction receipts
Stable ID: rna-pathogen-20261011-sanderson2026-config-alternative
- areas
- microbes-communities
- contexts
- clinical_research
- method types
- conventional_pipeline
- reported name
- Alternative post-hoc detection criterion
- parameters
- Reads mapping to the target genome as a percentage of reads on the run mapping to that genome > 0.037%, AND >= 2 target reads, replacing the main and ratio criteria; chosen after the validation results
- source locator
- Results 'Validation Set: Diagnostic performance' paragraph 6
- foundation model eligible
- false
- access reuse
- Laboratory workflow described in the preprint; not a released product
- missing metadata
- version: reason: unreported; note: minimap2 and basecaller versions are not given in the inspected text