Published clinical validation; transcribed, not reproduced.
1 evaluation · 6 results. Different protocols are not a single leaderboard.
Protocol: Target-level detection of respiratory pathogens against routine multiplex PCR, validation set (Sanderson et al. 2026) · Dataset: Validation set: 344 prospectively collected nasopharyngeal swabs (Sanderson et al. 2026)
Sorted by Recall (all PCR targets; target level; reference: routine multiplex PCR) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Recall (all PCR targets; target level; reference: routine multiplex PCR) | Recall (RNA pathogen targets excluding rhinovirus and enterovirus; target level; reference: routine multiplex PCR) | Recall (RNA pathogen targets only (adenovirus and bacteria excluded); target level; reference: routine multiplex PCR) | Recall (targets detectable by study qPCR; target level; reference: routine multiplex PCR) | Recall (targets with study qPCR Ct < 35; target level; reference: routine multiplex PCR) | Specificity (all PCR targets; target level; reference: routine multiplex PCR) |
|---|---|---|---|---|---|---|
| Alternative post-hoc detection criterion (Sanderson et al. 2026)Evaluation | 58% | 70% | 61% | 75% | 83% | 99.9% |
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19 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation Reads mapping to the target genome as a percentage of reads on the run mapping to that genome > 0.037%, AND >= 2 target reads, replacing the main and ratio criteria; chosen after the validation results Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation All targets in samples passing QC, or the stated subset Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget Not reported Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version Validation set, 344 nasopharyngeal swabs Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs RNA from nasopharyngeal swabs in viral transport medium Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation Target-level sensitivity and specificity against routine multiplex PCR Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population Pathogen targets in the samples passing QC Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id rna-pathogen-20261011-sanderson2026-protocol-validation Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Validation set Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Limitations2 values
| Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: rna-pathogen-20261011-sanderson2026-eval-alternative