rewirebio.iobenchmarks
Protocol

Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)

Each pipeline's reported viral hits scored against available RT-PCR results, including additional viruses with negative PCR.

13 evaluations · 78 results

Overview

Each pipeline's reported viral hits scored against available RT-PCR results, including additional viruses with negative PCR.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

13 recorded evaluations, 78 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

13 evaluations · 78 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Centrifuge as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
1 false-negative-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell Q10, row 'Centrifuge', column 'FN (number of PCR-positive hits not reported by mNGS)'
Configuration: Centrifuge as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
0 false-positive-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell O10, row 'Centrifuge', column 'Number of additional viral mNGS hits with negative PCR reprsult (FP* see manuscript text for comments e.g. on index hopping)'
Configuration: Centrifuge as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
14 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell R10, row 'Centrifuge', column 'Total mNGS hits with PCR data available (TP+FP)'
Configuration: Centrifuge as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
100% precision
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell S10, row 'Centrifuge', column 'Positive predictive value (PPV) [%]'
Configuration: Centrifuge as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
93.3% recall
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell T10, row 'Centrifuge', column 'Sensitivity [%], hit level'
Configuration: Centrifuge as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
14 true-positive-count
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell P10, row 'Centrifuge', column 'TP (viral mNGS hits with positive PCR result, mixed infections counted as double, out of 15 positive PCRs)'
Configuration: DAMIAN as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
3 false-negative-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

DAMIAN: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell Q15, row 'DAMIAN', column 'FN (number of PCR-positive hits not reported by mNGS)'
Configuration: DAMIAN as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
0 false-positive-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

DAMIAN: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell O15, row 'DAMIAN', column 'Number of additional viral mNGS hits with negative PCR reprsult (FP* see manuscript text for comments e.g. on index hopping)'
Configuration: DAMIAN as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
12 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

DAMIAN: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell R15, row 'DAMIAN', column 'Total mNGS hits with PCR data available (TP+FP)'
Configuration: DAMIAN as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
100% precision
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

DAMIAN: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell S15, row 'DAMIAN', column 'Positive predictive value (PPV) [%]'
Configuration: DAMIAN as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
80% recall
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

DAMIAN: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell T15, row 'DAMIAN', column 'Sensitivity [%], hit level'
Configuration: DAMIAN as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
12 true-positive-count
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Evaluation origin not reported · Source checked
Methods, coverage and source

DAMIAN: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell P15, row 'DAMIAN', column 'TP (viral mNGS hits with positive PCR result, mixed infections counted as double, out of 15 positive PCRs)'
Configuration: DIAMOND as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
2 false-negative-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DIAMOND: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell Q17, row 'DIAMOND', column 'FN (number of PCR-positive hits not reported by mNGS)'
Configuration: DIAMOND as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
1 false-positive-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DIAMOND: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell O17, row 'DIAMOND', column 'Number of additional viral mNGS hits with negative PCR reprsult (FP* see manuscript text for comments e.g. on index hopping)'
Configuration: DIAMOND as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
14 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DIAMOND: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell R17, row 'DIAMOND', column 'Total mNGS hits with PCR data available (TP+FP)'
Configuration: DIAMOND as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
92.9% precision
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DIAMOND: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell S17, row 'DIAMOND', column 'Positive predictive value (PPV) [%]'
Configuration: DIAMOND as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
86.7% recall
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DIAMOND: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell T17, row 'DIAMOND', column 'Sensitivity [%], hit level'
Configuration: DIAMOND as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
13 true-positive-count
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DIAMOND: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell P17, row 'DIAMOND', column 'TP (viral mNGS hits with positive PCR result, mixed infections counted as double, out of 15 positive PCRs)'
Configuration: DNAstar as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
0 false-negative-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DNAstar: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell Q20, row 'DNAstar', column 'FN (number of PCR-positive hits not reported by mNGS)'
Configuration: DNAstar as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
6 false-positive-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DNAstar: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell O20, row 'DNAstar', column 'Number of additional viral mNGS hits with negative PCR reprsult (FP* see manuscript text for comments e.g. on index hopping)'
Configuration: DNAstar as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
21 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DNAstar: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell R20, row 'DNAstar', column 'Total mNGS hits with PCR data available (TP+FP)'
Configuration: DNAstar as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
71.4% precision
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DNAstar: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell S20, row 'DNAstar', column 'Positive predictive value (PPV) [%]'
Configuration: DNAstar as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
100% recall
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DNAstar: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell T20, row 'DNAstar', column 'Sensitivity [%], hit level'
Configuration: DNAstar as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
15 true-positive-count
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DNAstar: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell P20, row 'DNAstar', column 'TP (viral mNGS hits with positive PCR result, mixed infections counted as double, out of 15 positive PCRs)'
Configuration: FEVIR as run by an ENNGS laboratory (de Vries et al. 2021)Protocol: Virus hits against RT-PCR: true and false positives, PPV and hit-level sensitivity (de Vries et al. 2021 Supplementary Table 4)
Dataset: ENNGS benchmark: 13 clinical metagenomic datasets with RT-PCR results (de Vries et al. 2021)
0 false-negative-count
count · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

FEVIR: virus hits against RT-PCR (ENNGS)

rna-pathogen-20261009-protocol-devries2021-hit-level

Aggregation: Not reported

de Vries et al. medRxiv preprint v1, Supplementary Tables 2-4 · Supplementary Table 4, cell Q23, row 'FEVIR', column 'FN (number of PCR-positive hits not reported by mNGS)'

Source checking is not independent reproduction. Release 2026-10-09-8cc1db47c7f9.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Explore all linked results

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

Author-reported evaluations
7
External evaluations
5
unreported
1

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Select a task-valid null control after reviewing inputs and metric

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Select an upstream conventional reference after reviewing the full protocol

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-09-8cc1db47c7f9. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

Run instructions

No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

Strengths, limitations and unresolved questions

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-8cc1db47c7f9
Property and statementOriginal source and locationReview and provenance

No evidence rows match these filters. Choose another scope or clear the search.

Sources and history

Release 2026-10-09-8cc1db47c7f9 · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: rna-pathogen-20261009-protocol-devries2021-hit-level

areas
microbes-communities
contexts
clinical_research
protocol
TP: reported hit with a positive PCR (mixed infections counted as two; 15 positive PCRs). FP: additional reported viral hit with a negative PCR result. FN: PCR-positive hit not reported. PPV = TP / (TP + FP); sensitivity = TP / 15. Hits without PCR data are not scored.
version
Supplementary Table 4, columns O-T
denominator
15
source locator
Results 'Additional virus hits and positive predictive value'; Supplementary Table 4 header row 5
limitations
False positives are counted only where a negative PCR exists; most additional hits have no PCR result.; The authors note that FP hits may be real (PCR primer mismatch) or index hopping or reagent contaminants.; Rotavirus was detected in the negative run control (Supplementary Table 4 footnote).
missing metadata
uncertainty: reason: unreported
Related records

Suggest a correction