Model

Optimus 5-Prime

Convolutional neural network that predicts mean ribosome load from 5' UTR sequence, trained on massively parallel reporter assays of random 5' UTRs and limited by position-specific weights to the lengths seen in training.

8 evaluations · 8 results

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Evaluations and results

8 evaluations · 8 results. Different protocols are not a single leaderboard.

Sorted by Pearson (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Pearson
Optimus 50Evaluation	FramePool study MRL: Random 50nt, Sample MPRA Random 50nt	0.966 (best in column)
Optimus 100Evaluation	FramePool study MRL: Random 50nt, Sample MPRA Random 50nt	0.938
Optimus 100Evaluation	FramePool study MRL: Random 25-100nt, Sample MPRA Random 25-100nt	0.915
Optimus 50Evaluation	FramePool study MRL: Human 50nt, Sample MPRA Human 50nt	0.889
Optimus 100Evaluation	FramePool study MRL: Human 25-100nt, Sample MPRA Human 25-100nt	0.882
Optimus 100Evaluation	FramePool study MRL: Human 50nt, Sample MPRA Human 50nt	0.852
Optimus 50Evaluation	FramePool study MRL: Random 25-100nt, Sample MPRA Random 25-100nt	0.743
Optimus 50Evaluation	FramePool study MRL: Human 25-100nt, Sample MPRA Human 25-100nt	0.7

All 8 result rows with coverage, uncertainty and sources

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Optimus 100	Protocol: FramePool study MRL: Human 25-100nt Dataset subset: Sample MPRA Human 25-100nt	0.882 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 100 Human 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell D5; row Human 25-100nt, column Optimus 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 50	Protocol: FramePool study MRL: Human 25-100nt Dataset subset: Sample MPRA Human 25-100nt	0.7 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 50 Human 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell B5; row Human 25-100nt, column Optimus 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 100	Protocol: FramePool study MRL: Human 50nt Dataset subset: Sample MPRA Human 50nt	0.852 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 100 Human 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell D4; row Human 50nt, column Optimus 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 50	Protocol: FramePool study MRL: Human 50nt Dataset subset: Sample MPRA Human 50nt	0.889 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 50 Human 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell B4; row Human 50nt, column Optimus 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 100	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.915 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 100 Random 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell D3; row Random 25-100nt, column Optimus 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 50	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.743 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 50 Random 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell B3; row Random 25-100nt, column Optimus 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 100	Protocol: FramePool study MRL: Random 50nt Dataset subset: Sample MPRA Random 50nt	0.938 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 100 Random 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell D2; row Random 50nt, column Optimus 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 50	Protocol: FramePool study MRL: Random 50nt Dataset subset: Sample MPRA Random 50nt	0.966 Pearson unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 50 Random 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell B2; row Random 50nt, column Optimus 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

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Optimus 100 · configuration of
Optimus 50 · configuration of

Evidence

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Description Convolutional neural network that predicts mean ribosome load from 5' UTR sequence, trained on massively parallel reporter assays of random 5' UTRs and limited by position-specific weights to the lengths seen in training. Individual claims	FramePool 2021 primary article Original source ↗ uc20260930-source-framepool-2021: Abstract; Introduction paragraphs 5-7 Version: 2021 journal article XML; PMC8136849.1 Retrieved: 2026-09-30	source checked ["automated-source-review","ai-assisted-source-review"] · 2026-10-10 Audit details Description written from the cited source text; provenance text was generic and is kept here as previous_value. Independent review 2026-10-10: every stated fact is supported by the cited text. Field: `description` Claim: metadata-correction-01bf5de6ca7da933d8a8 Source artifact SHA-256: `689af3ecab7b5a928eacc5a76d965960708cbb253fc7cdeae463b16d30ffd2e3` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

2 source records and release history

FramePool 2021 primary article · Original source · 2021 journal article XML; PMC8136849.1
FramePool Supplementary Table S1 · Original source · 2021 published S1 XLSX

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Technical metadata and extraction receipts

Stable ID: uc20260930-model-optimus-5-prime

areas: rna-transcriptomes
source locator: S1/S4 Table; Methods Framepool model and Model training; S7–S8 figure captions
review: method: automated-source-review; reviewer: codex; reviewed at: 2026-09-30T21:40:59.576893+00:00; scope: Primary-source transcription and catalogue applicability audit; not human scientific review or independent experimental reproduction.; reviewer note: role: experimental use-case curation
entity level: family
identity scope: Family/method identity only; no undocumented checkpoint equivalence.

Related records

subject: Optimus 5-Prime: description
configuration of: Optimus 100
configuration of: Optimus 50

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