Evaluation

Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2)

Published prospective cohort result; transcribed, not reproduced.

Evaluation results

1 evaluation · 18 results. Different protocols are not a single leaderboard.

Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) · Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)

Sorted by Recall (episode-level predictive sensitivity; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Recall (episode-level predictive sensitivity; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture)	Recall (episode-level predictive sensitivity; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture)	Recall (episode-level predictive sensitivity; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture)	Recall (episode-level predictive sensitivity; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture)	Recall (episode-level predictive sensitivity; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture)	Recall (episode-level predictive sensitivity; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture)	True positives (episodes with all culture organisms detected; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture)	True positives (episodes with all culture organisms detected; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture)	True positives (episodes with all culture organisms detected; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture)	True positives (episodes with all culture organisms detected; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture)	True positives (episodes with all culture organisms detected; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture)	True positives (episodes with all culture organisms detected; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture)	Count (evaluable episodes; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture)	Count (evaluable episodes; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture)	Count (evaluable episodes; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture)	Count (evaluable episodes; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture)	Count (evaluable episodes; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture)	Count (evaluable episodes; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture)
Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)Evaluation	51·9%	51·2%	53·8%	53·0%	51·4%	50·6%	42	44	42	44	38	40	81	86	78	83	74	79

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	86 Count (evaluable episodes; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	44 True positives (episodes with all culture organisms detected; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	51·2% Recall (episode-level predictive sensitivity; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 40.1 to 62.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	81 Count (evaluable episodes; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	42 True positives (episodes with all culture organisms detected; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	51·9% Recall (episode-level predictive sensitivity; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 40.5 to 63.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	83 Count (evaluable episodes; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	44 True positives (episodes with all culture organisms detected; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	53·0% Recall (episode-level predictive sensitivity; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 41.7 to 64.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	78 Count (evaluable episodes; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	42 True positives (episodes with all culture organisms detected; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	53·8% Recall (episode-level predictive sensitivity; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 42.2 to 65.2 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	79 Count (evaluable episodes; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	40 True positives (episodes with all culture organisms detected; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	50·6% Recall (episode-level predictive sensitivity; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 39.1 to 62.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	74 Count (evaluable episodes; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	38 True positives (episodes with all culture organisms detected; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	51·4% Recall (episode-level predictive sensitivity; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 39.4 to 63.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Sensitivity'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

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Evaluation procedure

Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2)

Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)
Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2)
Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)

origin: Author-reported evaluation
configuration: Primary source as retrieved 2026-10-11
protocol id: dna-pathogen-20261011-wolf2026-protocol-prediction
dataset version: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)
split: Single cohort
population: 94 bloodstream infection episodes (pilot and completion phases) in patients under 25 receiving leukaemia care at St Jude Children's Research Hospital, 2017-2022; leftover plasma from day -7 to day +1
inputs: Leftover clinical plasma, microbial cell-free DNA
adaptation: Any organism reported by the laboratory counts as positive.
metric implementation: Proportion of evaluable bloodstream infection episodes in which all organisms identified by blood culture were detected by mcfDNA-Seq in at least one sample from the 3 days before onset.
aggregation: Episodes (Table 2) or control samples (Table 3), raw or with logical imputation as printed
budget: Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split: Single cohort
Adaptation: Any organism reported by the laboratory counts as positive.
Scoring implementation: Proportion of evaluable bloodstream infection episodes in which all organisms identified by blood culture were detected by mcfDNA-Seq in at least one sample from the 3 days before onset.

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Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Comparison: adaptation Any organism reported by the laboratory counts as positive. Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: aggregation Episodes (Table 2) or control samples (Table 3), raw or with logical imputation as printed Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: budget Not reported Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: dataset version Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026) Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: inputs Leftover clinical plasma, microbial cell-free DNA Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: metric implementation Proportion of evaluable bloodstream infection episodes in which all organisms identified by blood culture were detected by mcfDNA-Seq in at least one sample from the 3 days before onset. Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.metric_implementation` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: population 94 bloodstream infection episodes (pilot and completion phases) in patients under 25 receiving leukaemia care at St Jude Children's Research Hospital, 2017-2022; leftover plasma from day -7 to day +1 Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.population` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: protocol id dna-pathogen-20261011-wolf2026-protocol-prediction Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.protocol_id` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: split Single cohort Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.split` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Limitations 1 values Testing was provided by Karius, whose representatives took part in sample processing, analysis and data management, and one author is a Karius employee (Declaration of interests; Role of the funding source). Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.limitations` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

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Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Original source · The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)

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Stable ID: dna-pathogen-20261011-wolf2026-eval-prediction

areas: microbes-communities
contexts: clinical_research
origin: author_reported
protocol: dna-pathogen-20261011-wolf2026-protocol-prediction
version: Primary source as retrieved 2026-10-11
comparison: protocol id: dna-pathogen-20261011-wolf2026-protocol-prediction; dataset version: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026); split: Single cohort; population: 94 bloodstream infection episodes (pilot and completion phases) in patients under 25 receiving leukaemia care at St Jude Children's Research Hospital, 2017-2022; leftover plasma from day -7 to day +1; inputs: Leftover clinical plasma, microbial cell-free DNA; adaptation: Any organism reported by the laboratory counts as positive.; metric implementation: Proportion of evaluable bloodstream infection episodes in which all organisms identified by blood culture were detected by mcfDNA-Seq in at least one sample from the 3 days before onset.; aggregation: Episodes (Table 2) or control samples (Table 3), raw or with logical imputation as printed; budget: Not reported
source locator: Table 2
limitations: Testing was provided by Karius, whose representatives took part in sample processing, analysis and data management, and one author is a Karius employee (Declaration of interests; Role of the funding source).

Related records

system: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)
assessment: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2)
data: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)
evaluation: wolf2026 prediction-all-imputed-evaluable
evaluation: wolf2026 prediction-all-imputed-positive
evaluation: wolf2026 prediction-all-imputed-sensitivity
evaluation: wolf2026 prediction-all-raw-evaluable
evaluation: wolf2026 prediction-all-raw-positive
evaluation: wolf2026 prediction-all-raw-sensitivity
evaluation: wolf2026 prediction-bacterial-imputed-evaluable
evaluation: wolf2026 prediction-bacterial-imputed-positive
evaluation: wolf2026 prediction-bacterial-imputed-sensitivity
evaluation: wolf2026 prediction-bacterial-raw-evaluable
evaluation: wolf2026 prediction-bacterial-raw-positive
evaluation: wolf2026 prediction-bacterial-raw-sensitivity
evaluation: wolf2026 prediction-common-imputed-evaluable
evaluation: wolf2026 prediction-common-imputed-positive
evaluation: wolf2026 prediction-common-imputed-sensitivity
evaluation: wolf2026 prediction-common-raw-evaluable
evaluation: wolf2026 prediction-common-raw-positive
evaluation: wolf2026 prediction-common-raw-sensitivity

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