Dataset

Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)

Prospectively collected leftover clinical plasma samples.

Evaluation results

2 evaluations · 36 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	88 Count (evaluable episodes; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	73 True positives (episodes with all culture organisms detected; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	83·0% Recall (episode-level diagnostic sensitivity; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 73.4 to 90.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	80 Count (evaluable episodes; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	65 True positives (episodes with all culture organisms detected; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	81·3% Recall (episode-level diagnostic sensitivity; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 71.0 to 89.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	85 Count (evaluable episodes; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	72 True positives (episodes with all culture organisms detected; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	84·7% Recall (episode-level diagnostic sensitivity; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 75.3 to 91.6 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	77 Count (evaluable episodes; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	64 True positives (episodes with all culture organisms detected; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	83·1% Recall (episode-level diagnostic sensitivity; bacterial bloodstream infections; raw data; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 72.9 to 90.7 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	82 Count (evaluable episodes; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	68 True positives (episodes with all culture organisms detected; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	82·9% Recall (episode-level diagnostic sensitivity; common bloodstream infection pathogens; with logical imputation of missing values; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 73.0 to 90.3 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Diagnosis (day 0 or 1)', block 'With logical imputation of missing values', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	75 Count (evaluable episodes; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	61 True positives (episodes with all culture organisms detected; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	81·3% Recall (episode-level diagnostic sensitivity; common bloodstream infection pathogens; raw data; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 70.7 to 89.4 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Diagnostic sensitivity, day 0 or 1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-diagnosis Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Common bloodstream infection pathogens (n=87)', row 'Diagnosis (day 0 or 1)', block 'Raw data', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	86 Count (evaluable episodes; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	44 True positives (episodes with all culture organisms detected; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	51·2% Recall (episode-level predictive sensitivity; all bloodstream infection episodes; with logical imputation of missing values; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 40.1 to 62.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	81 Count (evaluable episodes; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Evaluable episodes'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	42 True positives (episodes with all culture organisms detected; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) count · higher Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Positive'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	51·9% Recall (episode-level predictive sensitivity; all bloodstream infection episodes; raw data; reference: organisms identified by blood culture) percent · higher Uncertainty: 95% CI 40.5 to 63.1 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'All bloodstream infection episodes (n=94)', row 'Prediction (day −3 to −1)', block 'Raw data', column 'Sensitivity'
Configuration: Karius mcfDNA-Seq, all positive tests (Wolf et al. 2026)	Protocol: Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) Dataset: Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026)	83 Count (evaluable episodes; bacterial bloodstream infections; with logical imputation of missing values; reference: organisms identified by blood culture) count · unknown Uncertainty: Not applicable: Count Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Karius mcfDNA-Seq (all positive tests) on Predictive sensitivity, day -3 to -1 (Wolf et al. 2026 Table 2) dna-pathogen-20261011-wolf2026-protocol-prediction Aggregation: Not reported Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Table 2, group 'Bacterial bloodstream infections (n=91)', row 'Prediction (day −3 to −1)', block 'With logical imputation of missing values', column 'Evaluable episodes'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified
Sample annotations are recorded: not yet verified
Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
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Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Independent validation data exist: not yet verified
Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

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Dataset and evaluation context

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Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Access Not stated in the inspected text Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Methods 'Study design and participants'; Table 1; Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.access` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Population 94 bloodstream infection episodes (pilot and completion phases) in patients under 25 receiving leukaemia care at St Jude Children's Research Hospital, 2017-2022; leftover plasma from day -7 to day +1 Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Methods 'Study design and participants'; Table 1; Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.population` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Source location Methods 'Study design and participants'; Table 1; Table 2 Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Methods 'Study design and participants'; Table 1; Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Split Single prospective cohort; no split Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Methods 'Study design and participants'; Table 1; Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.split` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Version As described in Wolf et al. 2026 (consolidated pilot and completion phases) Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Methods 'Study design and participants'; Table 1; Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.version` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Description Prospectively collected leftover clinical plasma samples. Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Methods 'Study design and participants'; Table 1; Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded Audit details Field: `description` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Name Bloodstream infection episodes in children and young people with high-risk leukaemia (Wolf et al. 2026) Context-only references	Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Original source ↗ Methods 'Study design and participants'; Table 1; Table 2 Version: The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript) Retrieved: 2026-10-11T22:07:34Z	not individually reviewed No individual claim review recorded Audit details Field: `name` Source artifact SHA-256: `0f6905d0a0c9ace686bcc61970c711558ccf530b5c31f882607a305f8b5ca689` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study · Original source · The Lancet Microbe 7:101312, published online 2026-03-02; PMC13154368 full-text XML (author manuscript)

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Technical metadata and extraction receipts

Stable ID: dna-pathogen-20261011-wolf2026-data-bsi

areas: microbes-communities
contexts: clinical_research
version: As described in Wolf et al. 2026 (consolidated pilot and completion phases)
population: 94 bloodstream infection episodes (pilot and completion phases) in patients under 25 receiving leukaemia care at St Jude Children's Research Hospital, 2017-2022; leftover plasma from day -7 to day +1
split: Single prospective cohort; no split
access: Not stated in the inspected text
source locator: Methods 'Study design and participants'; Table 1; Table 2

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