143 BRCA1/BRCA2 variants curated end-to-end under the ENIGMA BRCA1/BRCA2 VCEP V1.2 specification in the ClinGen Evidence Repository (erepo.genome.network), used by the source as a clinical-grade reference standard.
These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.
Release 2026-10-06-fea06f63ac0e · Evidence verified: Not verified
Exact outcomes, predictions, identifiers and evaluator are connected.
Missing or unresolved evidence
Verified: Not verified
Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.
Missing or unresolved evidence
Verified: Not verified
A pinned recipe describes the inputs, environment and resource requirements.
Missing or unresolved evidence
Verified: Not verified
Separate data and exposure records support an independent test.
Missing or unresolved evidence
Verified: Not verified
Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.
No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.
1 evaluation · 2 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: HECTOR automated classifier (ENIGMA V1.2 specification) | Protocol: HECTOR vs. ENIGMA Evidence Repository (eRepo) agreement Dataset: ENIGMA Evidence Repository (eRepo) BRCA1/BRCA2 reference set | 75.5% (108/143) classification_agreement_rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceHECTOR eRepo concordance evaluation Not reported Aggregation: Not reported HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications · Results, "Evidence Repository": "At the classification level, HECTOR agreed with the ENIGMA VCEP classification for 108 of the 143 variants (75.5%)." |
| Configuration: HECTOR automated classifier (ENIGMA V1.2 specification) | Protocol: HECTOR vs. ENIGMA Evidence Repository (eRepo) agreement Dataset: ENIGMA Evidence Repository (eRepo) BRCA1/BRCA2 reference set | 78.9% (326/413) criteria_code_agreement_rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceHECTOR eRepo concordance evaluation Not reported Aggregation: Not reported HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications · Results, "Evidence Repository": "...the ENIGMA VCEP applied 413 evidence codes, of which HECTOR reproduced 326 (78.9%) at the identical code and strength (Figure 1)." |
Source checking is not independent reproduction. Release 2026-10-06-fea06f63ac0e.
A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
5 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.evidence_code_count 413 Context-only references | HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications Methods, "Validation Tier 1 - ENIGMA Evidence Repository" Version: medRxiv preprint v1, posted 2026-07-06 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.source_locator Methods, "Validation Tier 1 - ENIGMA Evidence Repository" Context-only references | HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications Methods, "Validation Tier 1 - ENIGMA Evidence Repository" Version: medRxiv preprint v1, posted 2026-07-06 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.variant_count 143 Context-only references | HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications Methods, "Validation Tier 1 - ENIGMA Evidence Repository" Version: medRxiv preprint v1, posted 2026-07-06 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| description 143 BRCA1/BRCA2 variants curated end-to-end under the ENIGMA BRCA1/BRCA2 VCEP V1.2 specification in the ClinGen Evidence Repository (erepo.genome.network), used by the source as a clinical-grade reference standard. Context-only references | HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications Methods, "Validation Tier 1 - ENIGMA Evidence Repository" Version: medRxiv preprint v1, posted 2026-07-06 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| name ENIGMA Evidence Repository (eRepo) BRCA1/BRCA2 reference set Context-only references | HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications Methods, "Validation Tier 1 - ENIGMA Evidence Repository" Version: medRxiv preprint v1, posted 2026-07-06 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
View linked audit checks and correction history
Release 2026-10-06-fea06f63ac0e · Record review: source checked
Stable ID: uc-clinical-20261005-hector-erepo-cohort