HECTOR automated classifier (ENIGMA V1.2 specification)
Web-based tool that automatically populates ACMG/AMP evidence codes derivable from public data under the ENIGMA BRCA1/BRCA2 VCEP V1.2 specification and returns a five-tier classification with code-level evidence; curator-dependent evidence is routed to manual input and is not auto-assigned.
Overview
Web-based tool that automatically populates ACMG/AMP evidence codes derivable from public data under the ENIGMA BRCA1/BRCA2 VCEP V1.2 specification and returns a five-tier classification with code-level evidence; curator-dependent evidence is routed to manual input and is not auto-assigned.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
1 evaluation · 2 results. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: HECTOR automated classifier (ENIGMA V1.2 specification) | Protocol: HECTOR vs. ENIGMA Evidence Repository (eRepo) agreement Dataset: ENIGMA Evidence Repository (eRepo) BRCA1/BRCA2 reference set | 75.5% (108/143) classification_agreement_rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceHECTOR eRepo concordance evaluation Not reported Aggregation: Not reported HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications · Results, "Evidence Repository": "At the classification level, HECTOR agreed with the ENIGMA VCEP classification for 108 of the 143 variants (75.5%)." |
| Configuration: HECTOR automated classifier (ENIGMA V1.2 specification) | Protocol: HECTOR vs. ENIGMA Evidence Repository (eRepo) agreement Dataset: ENIGMA Evidence Repository (eRepo) BRCA1/BRCA2 reference set | 78.9% (326/413) criteria_code_agreement_rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceHECTOR eRepo concordance evaluation Not reported Aggregation: Not reported HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications · Results, "Evidence Repository": "...the ENIGMA VCEP applied 413 evidence codes, of which HECTOR reproduced 326 (78.9%) at the identical code and strength (Figure 1)." |
Source checking is not independent reproduction. Release 2026-10-06-fea06f63ac0e.
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Evidence
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Sources and history
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Release 2026-10-06-fea06f63ac0e · Record review: source checked
1 source records and release history
- HECTOR: A Web-Based Tool for Automated BRCA1/BRCA2 Variant Classification Under the ClinGen ENIGMA Specifications · Original source · medRxiv preprint v1, posted 2026-07-06
Technical metadata and extraction receipts
Stable ID: uc-clinical-20261005-hector-v1-2-config
- areas
- dna-genomes
- contexts
- clinical_research
- review
- method: automated_source_review; reviewer: Claude Sonnet clinical coverage worker (research-evidence intake); date: 2026-10-05; note: Transcription from inspected primary source. No execution, independent replication or human scientific review.; source id: uc-clinical-20261005-source-hector-preprint
Related records
- configuration: HECTOR eRepo concordance evaluation