| Configuration: ESM Only | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.85 ± 0.036 AUPRC fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.036 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM Only: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row ESM Only, column AUPRC; XML row3 column7 |
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| Configuration: Combined | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.85 ± 0.021 MCC dimensionless · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.021 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCombined: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Combined, column MCC; XML row4 column6 |
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| Configuration: Original | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.94 AUROC fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceOriginal: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Original, column AUROC; XML row2 column8 |
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| Configuration: ESM Only | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.98 ± 0.004 Specificity fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM Only: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row ESM Only, column Specificity; XML row3 column4 |
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| Configuration: Combined | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.99 ± 0.004 Specificity fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCombined: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Combined, column Specificity; XML row4 column4 |
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| Configuration: ESM Only | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.75 ± 0.063 Sensitivity fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.063 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM Only: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row ESM Only, column Sensitivity; XML row3 column3 |
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| Configuration: Combined | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.97 ± 0.004 Weighted F1 fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCombined: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Combined, column Weighted F1; XML row4 column5 |
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| Configuration: Original | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.96 ± 0.008 Weighted F1 fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.008 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceOriginal: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Original, column Weighted F1; XML row2 column5 |
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| Configuration: ESM Only | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.96 ± 0.005 Val Accuracy fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.005 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM Only: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row ESM Only, column Val Accuracy; XML row3 column2 |
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| Configuration: Original | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.78 ± 0.046 MCC dimensionless · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.046 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceOriginal: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Original, column MCC; XML row2 column6 |
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| Configuration: Combined | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.97 ± 0.004 Val Accuracy fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCombined: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Combined, column Val Accuracy; XML row4 column2 |
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| Configuration: Original | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.84 ± 0.049 AUPRC fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.049 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceOriginal: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Original, column AUPRC; XML row2 column7 |
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| Configuration: Combined | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.92 ± 0.013 AUPRC fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.013 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCombined: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Combined, column AUPRC; XML row4 column7 |
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| Configuration: ESM Only | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.77 ± 0.043 MCC dimensionless · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.043 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM Only: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row ESM Only, column MCC; XML row3 column6 |
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| Configuration: Original | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.74 ± 0.071 Sensitivity fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.071 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceOriginal: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Original, column Sensitivity; XML row2 column3 |
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| Configuration: Original | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.96 ± 0.008 Val Accuracy fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.008 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceOriginal: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Original, column Val Accuracy; XML row2 column2 |
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| Configuration: ESM Only | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.94 AUROC fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM Only: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row ESM Only, column AUROC; XML row3 column8 |
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| Configuration: Combined | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.83 ± 0.045 Sensitivity fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.045 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCombined: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Combined, column Sensitivity; XML row4 column3 |
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| Configuration: Original | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.99 ± 0.004 Specificity fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceOriginal: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Original, column Specificity; XML row2 column4 |
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| Configuration: ESM Only | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.96 ± 0.007 Weighted F1 fraction · higher Uncertainty: type: reported_plus_minus_type_unresolved; value: 0.007 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM Only: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row ESM Only, column Weighted F1; XML row3 column5 |
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| Configuration: Combined | Protocol: Protective-antigen classification feature comparison (vaccine-antigen candidate prediction) Dataset: Protective-antigen classification feature comparison | 0.97 AUROC fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCombined: Protective-antigen classification feature comparison Original 509 features vs ESM 1,280 features vs combined 1,789 features. 372 protection-positive and 3,720 protection-negative samples. Aggregation: Not reported Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features · Table 1., row Combined, column AUROC; XML row4 column8 |
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