Configuration

Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)

5callers (>=3) as run in the cited comparison.

Overview

5callers (>=3) as run in the cited comparison.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

5 evaluations · 20 results. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls	137 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on CLL indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-cll-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D36; dataset 'CLL'; caller '5callers (>=3)'; column 'Count'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls	0.531 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on CLL indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-cll-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G36; dataset 'CLL'; caller '5callers (>=3)'; column 'F1'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls	0.526 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on CLL indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-cll-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F36; dataset 'CLL'; caller '5callers (>=3)'; column 'Precision'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls	0.537 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on CLL indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-cll-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E36; dataset 'CLL'; caller '5callers (>=3)'; column 'Recall'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls	728 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on COLO indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-colo829-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D60; dataset 'COLO'; caller '5callers (>=3)'; column 'Count'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls	0.624 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on COLO indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-colo829-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G60; dataset 'COLO'; caller '5callers (>=3)'; column 'F1'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls	0.503 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on COLO indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-colo829-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F60; dataset 'COLO'; caller '5callers (>=3)'; column 'Precision'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls	0.821 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on COLO indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-colo829-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E60; dataset 'COLO'; caller '5callers (>=3)'; column 'Recall'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 3 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 3 (WGS)	5450 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set3 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set3-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D12; dataset 'DREAM Set3'; caller '5callers (>=3)'; column 'Count'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 3 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 3 (WGS)	0.807 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set3 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set3-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G12; dataset 'DREAM Set3'; caller '5callers (>=3)'; column 'F1'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 3 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 3 (WGS)	0.995 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set3 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set3-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F12; dataset 'DREAM Set3'; caller '5callers (>=3)'; column 'Precision'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 3 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 3 (WGS)	0.679 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set3 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set3-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E12; dataset 'DREAM Set3'; caller '5callers (>=3)'; column 'Recall'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 4 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 4 (WGS)	8340 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set4 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set4-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D24; dataset 'DREAM Set4'; caller '5callers (>=3)'; column 'Count'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 4 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 4 (WGS)	0.738 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set4 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set4-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G24; dataset 'DREAM Set4'; caller '5callers (>=3)'; column 'F1'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 4 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 4 (WGS)	0.997 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set4 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set4-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F24; dataset 'DREAM Set4'; caller '5callers (>=3)'; column 'Precision'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: DREAM synthetic set 4 somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: ICGC-TCGA DREAM synthetic set 4 (WGS)	0.585 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on DREAM Set4 indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set4-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E24; dataset 'DREAM Set4'; caller '5callers (>=3)'; column 'Recall'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls	529 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D48; dataset 'MB'; caller '5callers (>=3)'; column 'Count'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls	0.717 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G48; dataset 'MB'; caller '5callers (>=3)'; column 'F1'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls	0.594 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F48; dataset 'MB'; caller '5callers (>=3)'; column 'Precision'
Configuration: Majority vote, 5 indel callers, at least 3 agree (Wang et al. 2020)	Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls	0.905 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5callers (>=3) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E48; dataset 'MB'; caller '5callers (>=3)'; column 'Recall'

Source checking is not independent reproduction. Release 2026-10-09-8cc1db47c7f9.

Use this model

How it works, versions and access

Strengths, limitations and unresolved questions

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-8cc1db47c7f9
Property and statement	Original source and location	Review and provenance

No evidence rows match these filters. Choose another scope or clear the search.

All evidence (JSONL) (gzip)How to read the evidence

Sources and history

Release 2026-10-09-8cc1db47c7f9 · Record review: source checked

2 source records and release history

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach · Original source · Scientific Reports 10:12898, published 2020-07-30; PMC7393490 full-text XML
Wang et al. 2020, Supplementary Tables (somatic caller performance) · Original source · 41598_2020_69772_MOESM3_ESM.xlsx (Supplementary Tables S1-S9) as served by the publisher

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: somatic-20261009-config-wang2020-vote-5callers-min3

areas: dna-genomes
contexts: clinical_research
method types: conventional_pipeline
reported name: 5callers (>=3)
protocol: Majority voting over LoFreq, MuTect2, Strelka, VarDict and VarScan; a call needs at least 3 callers
foundation model eligible: false
source locator: Methods, Somatic variant calling paragraph 1 and 2; Table S1/S2 row label '5callers (>=3)'
method role: Authors' own consensus approach evaluated alongside the individual callers
missing metadata: version: reason: inapplicable; note: Ensemble of the listed caller versions; no separate version

Related records

configuration of: Majority-vote consensus of somatic callers
system: 5callers (>=3) on CLL indels (Wang et al. 2020)
system: 5callers (>=3) on COLO indels (Wang et al. 2020)
system: 5callers (>=3) on DREAM Set3 indels (Wang et al. 2020)
system: 5callers (>=3) on DREAM Set4 indels (Wang et al. 2020)
system: 5callers (>=3) on MB indels (Wang et al. 2020)

Suggest a correction