rewirebio.iobenchmarks
Protocol

CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)

Per-caller recall, precision and F1 for somatic indels on one WGS tumour-normal pair.

12 evaluations · 48 results

Overview

Per-caller recall, precision and F1 for somatic indels on one WGS tumour-normal pair.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

12 recorded evaluations, 48 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

12 evaluations · 48 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
758 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D30; dataset 'CLL'; caller 'LoFreq'; column 'Count'
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.126 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G30; dataset 'CLL'; caller 'LoFreq'; column 'F1'
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.0739 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F30; dataset 'CLL'; caller 'LoFreq'; column 'Precision'
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.418 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E30; dataset 'CLL'; caller 'LoFreq'; column 'Recall'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
267 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D33; dataset 'CLL'; caller 'MuTect2'; column 'Count'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.279 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G33; dataset 'CLL'; caller 'MuTect2'; column 'F1'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.21 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F33; dataset 'CLL'; caller 'MuTect2'; column 'Precision'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.418 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E33; dataset 'CLL'; caller 'MuTect2'; column 'Recall'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
444 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D39; dataset 'CLL'; caller 'NeuSomatic_Lowqual'; column 'Count'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.159 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G39; dataset 'CLL'; caller 'NeuSomatic_Lowqual'; column 'F1'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.104 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F39; dataset 'CLL'; caller 'NeuSomatic_Lowqual'; column 'Precision'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.343 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E39; dataset 'CLL'; caller 'NeuSomatic_Lowqual'; column 'Recall'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
243 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D38; dataset 'CLL'; caller 'NeuSomatic_Pass'; column 'Count'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.228 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G38; dataset 'CLL'; caller 'NeuSomatic_Pass'; column 'F1'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.177 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F38; dataset 'CLL'; caller 'NeuSomatic_Pass'; column 'Precision'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.321 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E38; dataset 'CLL'; caller 'NeuSomatic_Pass'; column 'Recall'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
527 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D31; dataset 'CLL'; caller 'Strelka'; column 'Count'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.275 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G31; dataset 'CLL'; caller 'Strelka'; column 'F1'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.173 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F31; dataset 'CLL'; caller 'Strelka'; column 'Precision'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.679 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E31; dataset 'CLL'; caller 'Strelka'; column 'Recall'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
3250 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D28; dataset 'CLL'; caller 'VarDict (bcbio)'; column 'Count'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.039 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G28; dataset 'CLL'; caller 'VarDict (bcbio)'; column 'F1'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.0203 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F28; dataset 'CLL'; caller 'VarDict (bcbio)'; column 'Precision'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
0.493 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E28; dataset 'CLL'; caller 'VarDict (bcbio)'; column 'Recall'
Configuration: VarDict v1.6.0 standalone (Wang et al. 2020)Protocol: CLL tumour somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: Chronic lymphocytic leukaemia tumour-normal WGS with curated somatic calls
25300 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (standalone) on CLL indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-cll-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D29; dataset 'CLL'; caller 'VarDict (standalone)'; column 'Count'

Source checking is not independent reproduction. Release 2026-10-09-ba02f2f4a36e.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

Author-reported evaluations
4
External evaluations
8

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

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This is a suggested selection rule, not a validated method or a measured score.

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Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-09-ba02f2f4a36e. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

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Strengths, limitations and unresolved questions

Evidence

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Evidence table

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Sources and history

Release 2026-10-09-ba02f2f4a36e · Record review: source checked

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Technical metadata and extraction receipts

Stable ID: somatic-20261009-protocol-wang2020-cll-indel

areas
dna-genomes
contexts
clinical_research
protocol
Callers run on the tumour-normal pair with default settings or author instructions; calls compared with the truth set by the DREAM challenge evaluator.py. Recall = detected true variants / true variants; precision = detected true variants / all calls.
version
Supplementary S2 WGS INDELs, dataset 'CLL'
metric implementation
evaluator.py from Sage-Bionetworks/ICGC-TCGA-DREAM-Mutation-Calling-challenge-tools (commit not stated)
denominator
134
limitations
Single tumour-normal pair; no replicate or interval estimates.; Curated truth set of unclear completeness, especially at low VAF (Results 'Datasets for evaluation'); calls missing from the truth set count as false positives, so precision is a lower bound.; The source study treated calls below 2% VAF as unreliable, so the truth set lacks low-VAF variants (Discussion paragraph 5).; Caller versions are those listed in Methods (for example MuTect2 from GATK v3.7-0, Strelka v2.7.1); later releases may behave differently.
source locator
Supplementary Tables workbook sheet 'S2 WGS INDELs', rows for dataset 'CLL'; Methods 'Variant calling comparisons'
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