rewirebio.iobenchmarks
Protocol

COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)

Per-caller recall, precision and F1 for somatic indels on one WGS tumour-normal pair.

12 evaluations · 48 results

Overview

Per-caller recall, precision and F1 for somatic indels on one WGS tumour-normal pair.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

12 recorded evaluations, 48 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

12 evaluations · 48 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
1660 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D54; dataset 'COLO'; caller 'LoFreq'; column 'Count'
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.322 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G54; dataset 'COLO'; caller 'LoFreq'; column 'F1'
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.204 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F54; dataset 'COLO'; caller 'LoFreq'; column 'Precision'
Configuration: LoFreq v2.1.3.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.76 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LoFreq on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E54; dataset 'COLO'; caller 'LoFreq'; column 'Recall'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
678 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D57; dataset 'COLO'; caller 'MuTect2'; column 'Count'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.553 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G57; dataset 'COLO'; caller 'MuTect2'; column 'F1'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.459 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F57; dataset 'COLO'; caller 'MuTect2'; column 'Precision'
Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.697 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MuTect2 on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E57; dataset 'COLO'; caller 'MuTect2'; column 'Recall'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
1530 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D63; dataset 'COLO'; caller 'NeuSomatic_Lowqual'; column 'Count'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.269 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G63; dataset 'COLO'; caller 'NeuSomatic_Lowqual'; column 'F1'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.174 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F63; dataset 'COLO'; caller 'NeuSomatic_Lowqual'; column 'Precision'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.596 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Lowqual on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E63; dataset 'COLO'; caller 'NeuSomatic_Lowqual'; column 'Recall'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
932 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D62; dataset 'COLO'; caller 'NeuSomatic_Pass'; column 'Count'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.348 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G62; dataset 'COLO'; caller 'NeuSomatic_Pass'; column 'F1'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.258 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F62; dataset 'COLO'; caller 'NeuSomatic_Pass'; column 'Precision'
Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.538 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NeuSomatic_Pass on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E62; dataset 'COLO'; caller 'NeuSomatic_Pass'; column 'Recall'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
2150 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D55; dataset 'COLO'; caller 'Strelka'; column 'Count'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.301 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G55; dataset 'COLO'; caller 'Strelka'; column 'F1'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.182 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F55; dataset 'COLO'; caller 'Strelka'; column 'Precision'
Configuration: Strelka v2.7.1 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.874 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Strelka on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E55; dataset 'COLO'; caller 'Strelka'; column 'Recall'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
3900 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D52; dataset 'COLO'; caller 'VarDict (bcbio)'; column 'Count'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.157 f1-score
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G52; dataset 'COLO'; caller 'VarDict (bcbio)'; column 'F1'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.0877 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F52; dataset 'COLO'; caller 'VarDict (bcbio)'; column 'Precision'
Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
0.767 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (bcbio) on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E52; dataset 'COLO'; caller 'VarDict (bcbio)'; column 'Recall'
Configuration: VarDict v1.6.0 standalone (Wang et al. 2020)Protocol: COLO829 cell line somatic indels, WGS (Wang et al. 2020 Table S2)
Dataset: COLO829 metastatic melanoma cell line tumour-normal WGS with curated somatic calls
43300 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

VarDict (standalone) on COLO indels (Wang et al. 2020)

somatic-20261009-protocol-wang2020-colo829-indel

Aggregation: Not reported

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D53; dataset 'COLO'; caller 'VarDict (standalone)'; column 'Count'

Source checking is not independent reproduction. Release 2026-10-09-8cc1db47c7f9.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

Author-reported evaluations
4
External evaluations
8

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

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Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-09-8cc1db47c7f9. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

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Strengths, limitations and unresolved questions

Evidence

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Evidence table

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Sources and history

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Technical metadata and extraction receipts

Stable ID: somatic-20261009-protocol-wang2020-colo829-indel

areas
dna-genomes
contexts
clinical_research
protocol
Callers run on the tumour-normal pair with default settings or author instructions; calls compared with the truth set by the DREAM challenge evaluator.py. Recall = detected true variants / true variants; precision = detected true variants / all calls.
version
Supplementary S2 WGS INDELs, dataset 'COLO'
metric implementation
evaluator.py from Sage-Bionetworks/ICGC-TCGA-DREAM-Mutation-Calling-challenge-tools (commit not stated)
denominator
446
limitations
Single tumour-normal pair; no replicate or interval estimates.; Curated truth set of unclear completeness, especially at low VAF (Results 'Datasets for evaluation'); calls missing from the truth set count as false positives, so precision is a lower bound.; COLO829 is a cell line, not tumour tissue.; Caller versions are those listed in Methods (for example MuTect2 from GATK v3.7-0, Strelka v2.7.1); later releases may behave differently.
source locator
Supplementary Tables workbook sheet 'S2 WGS INDELs', rows for dataset 'COLO'; Methods 'Variant calling comparisons'
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