| Configuration: LoFreq v2.1.3.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 4560 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLoFreq on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D42; dataset 'MB'; caller 'LoFreq'; column 'Count' |
|---|
| Configuration: LoFreq v2.1.3.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.0861 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLoFreq on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G42; dataset 'MB'; caller 'LoFreq'; column 'F1' |
|---|
| Configuration: LoFreq v2.1.3.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.0463 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLoFreq on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F42; dataset 'MB'; caller 'LoFreq'; column 'Precision' |
|---|
| Configuration: LoFreq v2.1.3.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.608 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLoFreq on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E42; dataset 'MB'; caller 'LoFreq'; column 'Recall' |
|---|
| Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 1570 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceMuTect2 on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D45; dataset 'MB'; caller 'MuTect2'; column 'Count' |
|---|
| Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.233 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceMuTect2 on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G45; dataset 'MB'; caller 'MuTect2'; column 'F1' |
|---|
| Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.142 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceMuTect2 on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F45; dataset 'MB'; caller 'MuTect2'; column 'Precision' |
|---|
| Configuration: MuTect2 (GATK v3.7-0) (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.643 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceMuTect2 on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E45; dataset 'MB'; caller 'MuTect2'; column 'Recall' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 1040 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Lowqual on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D51; dataset 'MB'; caller 'NeuSomatic_Lowqual'; column 'Count' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.078 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Lowqual on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G51; dataset 'MB'; caller 'NeuSomatic_Lowqual'; column 'F1' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.052 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Lowqual on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F51; dataset 'MB'; caller 'NeuSomatic_Lowqual'; column 'Precision' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, all calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.156 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Lowqual on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E51; dataset 'MB'; caller 'NeuSomatic_Lowqual'; column 'Recall' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 475 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Pass on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D50; dataset 'MB'; caller 'NeuSomatic_Pass'; column 'Count' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.117 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Pass on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G50; dataset 'MB'; caller 'NeuSomatic_Pass'; column 'F1' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.101 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Pass on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F50; dataset 'MB'; caller 'NeuSomatic_Pass'; column 'Precision' |
|---|
| Configuration: NeuSomatic v0.2.1 ensemble mode, DREAM3 model, PASS calls (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.138 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNeuSomatic_Pass on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E50; dataset 'MB'; caller 'NeuSomatic_Pass'; column 'Recall' |
|---|
| Configuration: Strelka v2.7.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 5370 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceStrelka on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D43; dataset 'MB'; caller 'Strelka'; column 'Count' |
|---|
| Configuration: Strelka v2.7.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.119 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceStrelka on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G43; dataset 'MB'; caller 'Strelka'; column 'F1' |
|---|
| Configuration: Strelka v2.7.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.0635 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceStrelka on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F43; dataset 'MB'; caller 'Strelka'; column 'Precision' |
|---|
| Configuration: Strelka v2.7.1 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.983 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceStrelka on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E43; dataset 'MB'; caller 'Strelka'; column 'Recall' |
|---|
| Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 7560 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceVarDict (bcbio) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D40; dataset 'MB'; caller 'VarDict (bcbio)'; column 'Count' |
|---|
| Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.0779 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceVarDict (bcbio) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', G40; dataset 'MB'; caller 'VarDict (bcbio)'; column 'F1' |
|---|
| Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.0407 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceVarDict (bcbio) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', F40; dataset 'MB'; caller 'VarDict (bcbio)'; column 'Precision' |
|---|
| Configuration: VarDict through bcbio-nextgen v1.1.5 (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 0.888 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceVarDict (bcbio) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', E40; dataset 'MB'; caller 'VarDict (bcbio)'; column 'Recall' |
|---|
| Configuration: VarDict v1.6.0 standalone (Wang et al. 2020) | Protocol: MB brain tumour somatic indels, WGS (Wang et al. 2020 Table S2) Dataset: Malignant paediatric cerebellar brain tumour (MB) tumour-normal WGS with curated somatic calls | 83300 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceVarDict (standalone) on MB indels (Wang et al. 2020) somatic-20261009-protocol-wang2020-mb-indel Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S2 WGS INDELs', D41; dataset 'MB'; caller 'VarDict (standalone)'; column 'Count' |
|---|