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AlphaFold3

AlphaFold3: AlphaFold3 server configuration; five models from one run.

6 evaluations · 12 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

6 evaluations · 12 results. Different protocols are not a single leaderboard.

Sorted by Casp sum z score (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationProtocol and datasetCasp sum z scoreRMSD
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1107-sum_z_gdt_ts_tm_score: R1107: Sum of Z-scores for GDT-TS and TM-score, CASP15 natural RNA target R1107 (RhoFold+ 2024 CASP15 natural RNA comparison split)3.43 (best in column)Not reported
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1156-sum_z_gdt_ts_tm_score: R1156: Sum of Z-scores for GDT-TS and TM-score, CASP15 natural RNA target R1156 (RhoFold+ 2024 CASP15 natural RNA comparison split)2.93Not reported
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1116-sum_z_gdt_ts_tm_score: R1116: Sum of Z-scores for GDT-TS and TM-score, CASP15 natural RNA target R1116 (RhoFold+ 2024 CASP15 natural RNA comparison split)2.52Not reported
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1108-sum_z_gdt_ts_tm_score: R1108: Sum of Z-scores for GDT-TS and TM-score, CASP15 natural RNA target R1108 (RhoFold+ 2024 CASP15 natural RNA comparison split)2.06Not reported
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1117-sum_z_gdt_ts_tm_score: R1117: Sum of Z-scores for GDT-TS and TM-score, CASP15 natural RNA target R1117 (RhoFold+ 2024 CASP15 natural RNA comparison split)1.97Not reported
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1149-sum_z_gdt_ts_tm_score: R1149: Sum of Z-scores for GDT-TS and TM-score, CASP15 natural RNA target R1149 (RhoFold+ 2024 CASP15 natural RNA comparison split)1.81Not reported
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1107-rmsd: R1107: RMSD, CASP15 natural RNA target R1107 (RhoFold+ 2024 CASP15 natural RNA comparison split)Not reported6.03 Å
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1108-rmsd: R1108: RMSD, CASP15 natural RNA target R1108 (RhoFold+ 2024 CASP15 natural RNA comparison split)Not reported5.62 Å
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1116-rmsd: R1116: RMSD, CASP15 natural RNA target R1116 (RhoFold+ 2024 CASP15 natural RNA comparison split)Not reported15.78 Å
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1117-rmsd: R1117: RMSD, CASP15 natural RNA target R1117 (RhoFold+ 2024 CASP15 natural RNA comparison split)Not reported2.61 Å (best in column)
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1149-rmsd: R1149: RMSD, CASP15 natural RNA target R1149 (RhoFold+ 2024 CASP15 natural RNA comparison split)Not reported15.23 Å
AlphaFold3EvaluationRhoFold+ 2024 CASP15 natural RNA comparison R1156-rmsd: R1156: RMSD, CASP15 natural RNA target R1156 (RhoFold+ 2024 CASP15 natural RNA comparison split)Not reported20.91 Å
All 12 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1107-rmsd: R1107: RMSD
Dataset subset: CASP15 natural RNA target R1107 (RhoFold+ 2024 CASP15 natural RNA comparison split)
6.03 Å RMSD
angstrom · lower

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1107-rmsd: R1107: RMSD

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!B10; method fig2hi!A10; target fig2hi!B1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1107-sum_z_gdt_ts_tm_score: R1107: Sum of Z-scores for GDT-TS and TM-score
Dataset subset: CASP15 natural RNA target R1107 (RhoFold+ 2024 CASP15 natural RNA comparison split)
3.43 Casp sum z score
unitless · higher

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1107-sum_z_gdt_ts_tm_score: R1107: Sum of Z-scores for GDT-TS and TM-score

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!H10; method fig2hi!A10; target fig2hi!H1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1108-rmsd: R1108: RMSD
Dataset subset: CASP15 natural RNA target R1108 (RhoFold+ 2024 CASP15 natural RNA comparison split)
5.62 Å RMSD
angstrom · lower

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1108-rmsd: R1108: RMSD

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!C10; method fig2hi!A10; target fig2hi!C1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1108-sum_z_gdt_ts_tm_score: R1108: Sum of Z-scores for GDT-TS and TM-score
Dataset subset: CASP15 natural RNA target R1108 (RhoFold+ 2024 CASP15 natural RNA comparison split)
2.06 Casp sum z score
unitless · higher

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1108-sum_z_gdt_ts_tm_score: R1108: Sum of Z-scores for GDT-TS and TM-score

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!I10; method fig2hi!A10; target fig2hi!I1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1116-rmsd: R1116: RMSD
Dataset subset: CASP15 natural RNA target R1116 (RhoFold+ 2024 CASP15 natural RNA comparison split)
15.78 Å RMSD
angstrom · lower

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1116-rmsd: R1116: RMSD

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!D10; method fig2hi!A10; target fig2hi!D1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1116-sum_z_gdt_ts_tm_score: R1116: Sum of Z-scores for GDT-TS and TM-score
Dataset subset: CASP15 natural RNA target R1116 (RhoFold+ 2024 CASP15 natural RNA comparison split)
2.52 Casp sum z score
unitless · higher

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1116-sum_z_gdt_ts_tm_score: R1116: Sum of Z-scores for GDT-TS and TM-score

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!J10; method fig2hi!A10; target fig2hi!J1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1117-rmsd: R1117: RMSD
Dataset subset: CASP15 natural RNA target R1117 (RhoFold+ 2024 CASP15 natural RNA comparison split)
2.61 Å RMSD
angstrom · lower

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1117-rmsd: R1117: RMSD

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!E10; method fig2hi!A10; target fig2hi!E1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1117-sum_z_gdt_ts_tm_score: R1117: Sum of Z-scores for GDT-TS and TM-score
Dataset subset: CASP15 natural RNA target R1117 (RhoFold+ 2024 CASP15 natural RNA comparison split)
1.97 Casp sum z score
unitless · higher

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1117-sum_z_gdt_ts_tm_score: R1117: Sum of Z-scores for GDT-TS and TM-score

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!K10; method fig2hi!A10; target fig2hi!K1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1149-rmsd: R1149: RMSD
Dataset subset: CASP15 natural RNA target R1149 (RhoFold+ 2024 CASP15 natural RNA comparison split)
15.23 Å RMSD
angstrom · lower

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1149-rmsd: R1149: RMSD

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!F10; method fig2hi!A10; target fig2hi!F1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1149-sum_z_gdt_ts_tm_score: R1149: Sum of Z-scores for GDT-TS and TM-score
Dataset subset: CASP15 natural RNA target R1149 (RhoFold+ 2024 CASP15 natural RNA comparison split)
1.81 Casp sum z score
unitless · higher

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1149-sum_z_gdt_ts_tm_score: R1149: Sum of Z-scores for GDT-TS and TM-score

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!L10; method fig2hi!A10; target fig2hi!L1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1156-rmsd: R1156: RMSD
Dataset subset: CASP15 natural RNA target R1156 (RhoFold+ 2024 CASP15 natural RNA comparison split)
20.91 Å RMSD
angstrom · lower

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1156-rmsd: R1156: RMSD

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!G10; method fig2hi!A10; target fig2hi!G1; Fig. 2h caption; XML Par13–15 and Par51
Configuration: AlphaFold3Protocol: RhoFold+ 2024 CASP15 natural RNA comparison R1156-sum_z_gdt_ts_tm_score: R1156: Sum of Z-scores for GDT-TS and TM-score
Dataset subset: CASP15 natural RNA target R1156 (RhoFold+ 2024 CASP15 natural RNA comparison split)
2.93 Casp sum z score
unitless · higher

Uncertainty: Not yet extracted

Coverage: 1/1 CASP15 natural RNA target scored (Per-cell target count; source retains up to five candidate structures, not five independent evaluation targets.)

Independent external evaluation · Source checked
Methods, coverage and source

AlphaFold3 on RhoFold+ 2024 CASP15 natural RNA comparison R1156-sum_z_gdt_ts_tm_score: R1156: Sum of Z-scores for GDT-TS and TM-score

Retrospective evaluation of six CASP15 natural single-chain RNA targets; each task retains one named target. Artificially designed targets and RNA-protein complexes excluded. RNA sequence inputs without ions or other molecules. Paper Par13 selects the highest-performing of five candidates; Par51 describes five sampled-MSA runs for RhoFold+, one AlphaFold3 server run yielding five models, and five CASP15 models for the other methods. Figure 2h reports RMSD and sum of Z-scores for GDT-TS and TM-score. Metric-specific winning candidate identity, exact scoring-tool revision and RMSD atom selection remain unextracted. No target pooling or score recomputation.

Aggregation: Source-reported selected candidate for one target; no cross-target aggregation.

RhoFold+ Nature Methods 2024: Source Data Figure 2h · fig2hi!M10; method fig2hi!A10; target fig2hi!M1; Fig. 2h caption; XML Par13–15 and Par51

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

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Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

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Stable ID: rhofold-2024-casp15-natural-method-alphafold3

areas
rna-transcriptomes
source locator
fig2hi!A10; Figure 2h; primary XML Par13–15 and Par51
missing metadata
checkpoint revision: reason: unreported; parameters: reason: unextracted
provenance note
AlphaFold3 server configuration evaluated by the RhoFold+ paper authors; five models from one run.
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