EVO1.5 (8k_base) (zero-shot, Wang et al. 2026); https://huggingface.co/evo-design/evo-1.5-8k-base (downloaded 2025/12/17; version column 'evo-1.5-8k-base (8k_base)'; variant label in results tables '8k_base')

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Evaluations and results

6 evaluations · 6 results. Different protocols are not a single leaderboard.

Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)

Sorted by Absolute spearman correlation (PLL-D; mean over assays) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Absolute spearman correlation (PLL-D; mean over assays)	Absolute spearman correlation (PLL-D; median over assays)	AUROC (PLL-D; mean over assays)	AUROC (PLL-D; median over assays)	MCC (PLL-D; mean over assays)	MCC (PLL-D; median over assays)
EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays)	0.179±0.114	Not reported	Not reported	Not reported	Not reported	Not reported
EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays)	Not reported	Not reported	0.588±0.056	Not reported	Not reported	Not reported
EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays)	Not reported	Not reported	Not reported	0.586	Not reported	Not reported
EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays)	Not reported	Not reported	Not reported	Not reported	0.132±0.088	Not reported
EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays)	Not reported	Not reported	Not reported	Not reported	Not reported	0.13
EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays)	Not reported	0.178	Not reported	Not reported	Not reported	Not reported

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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.588±0.056 AUROC (PLL-D; mean over assays) unitless · higher Uncertainty: SD 0.056 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EVO1.5 (8k_base) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'EVO1.5 (8k_base)', column 'AUC' (Mean ± Std)
Configuration: EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.586 AUROC (PLL-D; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EVO1.5 (8k_base) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'EVO1.5 (8k_base)', column 'AUC' (Median)
Configuration: EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.132±0.088 MCC (PLL-D; mean over assays) unitless · higher Uncertainty: SD 0.088 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EVO1.5 (8k_base) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'EVO1.5 (8k_base)', column 'MCC' (Mean ± Std)
Configuration: EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.13 MCC (PLL-D; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EVO1.5 (8k_base) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'EVO1.5 (8k_base)', column 'MCC' (Median)
Configuration: EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.179±0.114 Absolute spearman correlation (PLL-D; mean over assays) unitless · higher Uncertainty: SD 0.114 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EVO1.5 (8k_base) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'EVO1.5 (8k_base)', column 'SR' (Mean ± Std)
Configuration: EVO1.5 (8k_base) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.178 Absolute spearman correlation (PLL-D; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source EVO1.5 (8k_base) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'EVO1.5 (8k_base)', column 'SR' (Median)

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Zero-shot benchmarking of RNA language models: Supplementary Information · Original source · bbag098_supplymentary_information_20260209.docx from the Europe PMC supplementary files archive for PMC12963973

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Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rnalm-zeroshot-config-evo1-5-8k-base-wang2026

areas: rna-transcriptomes
contexts: research
method types: foundation_model
reported name: EVO1.5 (8k_base)
foundation model eligible: true
parameters: Pretrained weights used without fine-tuning (zero-shot); attention maps, embeddings or token logits read out as described in the Methods
access reuse: Public download location listed in Supplementary Table 1
source locator: Supplementary Table 1 row 'EVO1.5'
checkpoint: https://huggingface.co/evo-design/evo-1.5-8k-base (downloaded 2025/12/17; version column 'evo-1.5-8k-base (8k_base)'; variant label in results tables '8k_base')
version: 8k_base

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