ESM-untrained (mut mean)

Overview

Protein language model embedding with the stated pooling, fed to a supervised head by the FLIP authors.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

10 evaluations · 10 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESM-untrained (mut mean)	Task: FLIP AAV-1-VS-REST: AAV fitness prediction, 1-vs-rest split Dataset subset: FLIP AAV, 1-vs-rest split (FLIP split)	0.26 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP AAV-1-VS-REST: AAV fitness prediction, 1-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (mut mean)), column(1-vs-rest)
Configuration: ESM-untrained (mut mean)	Task: FLIP AAV-2-VS-REST: AAV fitness prediction, 2-vs-rest split Dataset subset: FLIP AAV, 2-vs-rest split (FLIP split)	0.16 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP AAV-2-VS-REST: AAV fitness prediction, 2-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (mut mean)), column(2-vs-rest)
Configuration: ESM-untrained (mut mean)	Task: FLIP AAV-7-VS-REST: AAV fitness prediction, 7-vs-rest split Dataset subset: FLIP AAV, 7-vs-rest split (FLIP split)	0.56 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP AAV-7-VS-REST: AAV fitness prediction, 7-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (mut mean)), column(7-vs-rest)
Configuration: ESM-untrained (mut mean)	Task: FLIP AAV-DES-MUT: AAV fitness prediction, Des-Mut split Dataset subset: FLIP AAV, Des-Mut split (FLIP split)	0.64 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP AAV-DES-MUT: AAV fitness prediction, Des-Mut split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (mut mean)), column(Des-Mut)
Configuration: ESM-untrained (mut mean)	Task: FLIP AAV-LOW-VS-HIGH: AAV fitness prediction, low-vs-high split Dataset subset: FLIP AAV, low-vs-high split (FLIP split)	0.24 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP AAV-LOW-VS-HIGH: AAV fitness prediction, low-vs-high split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (mut mean)), column(low-vs-high)
Configuration: ESM-untrained (mut mean)	Task: FLIP AAV-MUT-DES: AAV fitness prediction, Mut-Des split Dataset subset: FLIP AAV, Mut-Des split (FLIP split)	0.62 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP AAV-MUT-DES: AAV fitness prediction, Mut-Des split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (mut mean)), column(Mut-Des)
Configuration: ESM-untrained (mut mean)	Task: FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Dataset subset: FLIP GB1, 1-vs-rest split (FLIP split)	0.21 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (mut mean)), column(1-vs-rest)
Configuration: ESM-untrained (mut mean)	Task: FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Dataset subset: FLIP GB1, 2-vs-rest split (FLIP split)	0.21 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (mut mean)), column(2-vs-rest)
Configuration: ESM-untrained (mut mean)	Task: FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Dataset subset: FLIP GB1, 3-vs-rest split (FLIP split)	0.57 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (mut mean)), column(3-vs-rest)
Configuration: ESM-untrained (mut mean)	Task: FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Dataset subset: FLIP GB1, low-vs-high split (FLIP split)	0.13 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (mut mean) on FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (mut mean)), column(low-vs-high)

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

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Evidence

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Evidence table

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