Benchmark

FramePool translation-prediction study

2021 MPRA mean-ribosome-load comparisons for random and truncated-human UTR libraries across fixed and variable lengths.

30 evaluations · 30 results

Overview

2021 MPRA mean-ribosome-load comparisons for random and truncated-human UTR libraries across fixed and variable lengths.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

30 recorded evaluations, 30 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

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Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

30 evaluations · 30 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: FramePool 100	Protocol: FramePool study MRL: Human 25-100nt Dataset subset: Sample MPRA Human 25-100nt	0.884 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool 100 Human 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell E5; row Human 25-100nt, column FramePool 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: FramePool 50	Protocol: FramePool study MRL: Human 25-100nt Dataset subset: Sample MPRA Human 25-100nt	0.871 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool 50 Human 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell C5; row Human 25-100nt, column FramePool 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: FramePool Combined	Protocol: FramePool study MRL: Human 25-100nt Dataset subset: Sample MPRA Human 25-100nt	0.894 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool Combined Human 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell F5; row Human 25-100nt, column FramePool Combined; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 100	Protocol: FramePool study MRL: Human 25-100nt Dataset subset: Sample MPRA Human 25-100nt	0.882 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 100 Human 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell D5; row Human 25-100nt, column Optimus 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 50	Protocol: FramePool study MRL: Human 25-100nt Dataset subset: Sample MPRA Human 25-100nt	0.7 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 50 Human 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell B5; row Human 25-100nt, column Optimus 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: FramePool 100	Protocol: FramePool study MRL: Human 50nt Dataset subset: Sample MPRA Human 50nt	0.839 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool 100 Human 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell E4; row Human 50nt, column FramePool 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: FramePool 50	Protocol: FramePool study MRL: Human 50nt Dataset subset: Sample MPRA Human 50nt	0.882 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool 50 Human 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell C4; row Human 50nt, column FramePool 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: FramePool Combined	Protocol: FramePool study MRL: Human 50nt Dataset subset: Sample MPRA Human 50nt	0.867 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool Combined Human 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell F4; row Human 50nt, column FramePool Combined; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 100	Protocol: FramePool study MRL: Human 50nt Dataset subset: Sample MPRA Human 50nt	0.852 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 100 Human 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell D4; row Human 50nt, column Optimus 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 50	Protocol: FramePool study MRL: Human 50nt Dataset subset: Sample MPRA Human 50nt	0.889 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 50 Human 50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell B4; row Human 50nt, column Optimus 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: 3mer_random_forest	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.616 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 3mer_random_forest random-25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell C2; row 3mer_random_forest; S7–S8 MPRA correlation plots
Configuration: 4mer_random_forest	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.647 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 4mer_random_forest random-25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell C3; row 4mer_random_forest; S7–S8 MPRA correlation plots
Configuration: 5mer_frame_forest	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.73 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5mer_frame_forest random-25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell C6; row 5mer_frame_forest; S7–S8 MPRA correlation plots
Configuration: frame_forest (4mer)	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.772 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source frame_forest (4mer) random-25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell C4; row frame_forest (4mer); S7–S8 MPRA correlation plots
Configuration: frame_forest_hyperopt	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.778 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source frame_forest_hyperopt random-25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell C5; row frame_forest_hyperopt; S7–S8 MPRA correlation plots
Configuration: FramePool 100	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.903 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool 100 Random 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell E3; row Random 25-100nt, column FramePool 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: FramePool 50	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.901 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool 50 Random 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell C3; row Random 25-100nt, column FramePool 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: FramePool Combined	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.914 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source FramePool Combined Random 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell F3; row Random 25-100nt, column FramePool Combined; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 100	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.915 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 100 Random 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell D3; row Random 25-100nt, column Optimus 100; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: Optimus 50	Protocol: FramePool study MRL: Random 25-100nt Dataset subset: Sample MPRA Random 25-100nt	0.743 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Optimus 50 Random 25-100nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S1 · S1 Table cell B3; row Random 25-100nt, column Optimus 50; main text Evaluating frame pooling on MPRA data identifies Pearson correlation
Configuration: 3mer_random_forest	Protocol: FramePool study MRL: Random 50nt Dataset subset: Sample MPRA Random 50nt	0.732 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 3mer_random_forest random-50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell B2; row 3mer_random_forest; S7–S8 MPRA correlation plots
Configuration: 4mer_random_forest	Protocol: FramePool study MRL: Random 50nt Dataset subset: Sample MPRA Random 50nt	0.75 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 4mer_random_forest random-50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell B3; row 4mer_random_forest; S7–S8 MPRA correlation plots
Configuration: 5mer_frame_forest	Protocol: FramePool study MRL: Random 50nt Dataset subset: Sample MPRA Random 50nt	0.803 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source 5mer_frame_forest random-50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell B6; row 5mer_frame_forest; S7–S8 MPRA correlation plots
Configuration: frame_forest (4mer)	Protocol: FramePool study MRL: Random 50nt Dataset subset: Sample MPRA Random 50nt	0.877 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source frame_forest (4mer) random-50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell B4; row frame_forest (4mer); S7–S8 MPRA correlation plots
Configuration: frame_forest_hyperopt	Protocol: FramePool study MRL: Random 50nt Dataset subset: Sample MPRA Random 50nt	0.876 pearson_r correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source frame_forest_hyperopt random-50nt Not reported Aggregation: Not reported FramePool 2021 primary article; FramePool Supplementary Table S4 · S4 Table cell B5; row frame_forest_hyperopt; S7–S8 MPRA correlation plots

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Evaluation design

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Protocols

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Baseline coverage

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0 of 8 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

Baseline status by linked protocol

FramePool study MRL: Human 25-100nt · 0/2 roles measured
FramePool study MRL: Human 50nt · 0/2 roles measured
FramePool study MRL: Random 25-100nt · 0/2 roles measured
FramePool study MRL: Random 50nt · 0/2 roles measured

Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums

Coverage is derived from release 2026-09-30-e37e3ab1284d. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

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Strengths, limitations and unresolved questions

Evidence

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Evidence table

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Sources and history

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Release 2026-09-30-e37e3ab1284d · Record review: source checked

2 source records and release history

FramePool 2021 primary article · Original source · 2021 journal article XML; PMC8136849.1
FramePool Supplementary Table S1 · Original source · 2021 published S1 XLSX

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Technical metadata and extraction receipts

Stable ID: uc20260930-benchmark-framepool

areas: rna-transcriptomes
entity level: suite
source locator: Supplementary Tables S1 and S4; Model training and testing
review: method: automated_source_review; reviewed at: 2026-09-30T21:44:09.612264+00:00; date: 2026-09-30; reviewer: Codex experimental-use-case curation; scope: Source-backed study/suite containment for navigation, not shared numerical comparison or execution.
limitations: Containment groups the original study only. Each protocol retains separate datasets, input assumptions, endpoints and values.

Related records

part of: FramePool study MRL: Human 25-100nt
part of: FramePool study MRL: Human 50nt
part of: FramePool study MRL: Random 25-100nt
part of: FramePool study MRL: Random 50nt

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