rewirebio.iobenchmarks

Biological models

Understand model architectures, biological inputs, access requirements and the evidence from linked evaluations.

318 model records in release 2026-10-23-5347695500ed (release manifest, gzip). Showing 289–312; page 13 of 14.

Evaluated configurations, methods and pipelines are listed separately. Names alone do not establish equivalent models or checkpoints.

  • SpliceBERT

    DNA and genomes

    BERT-style RNA language model trained by masked token prediction on precursor RNA from 72 vertebrate species, used for splice site, branchpoint and splicing variant effect prediction.

    Record: lit-genomics-20261011-geneb-model-splicebert

  • SpTransformer

    DNA and genomes

    Task-specific transformer for tissue-specific splice site prediction.

  • STATE

    Single-cell omics

    State separates cellular representation learning from prediction of responses to perturbation.

  • SweetNet

    Glycans

    SweetNet predicts glycan properties and produces learned representations from glycan graphs.

  • TAPE Bepler

    Protein function

    The TAPE Bepler comparison uses a protein representation that combines bidirectional language modelling with supervised structural pretraining.

  • TAPE LSTM

    Protein function

    The TAPE LSTM baseline represents protein sequences using recurrent networks that read residues in both directions.

  • TAPE ResNet

    Protein function

    The TAPE ResNet baseline represents protein sequences using residual convolutional blocks before a task-specific prediction head.

  • TAPE Transformer

    Protein function

    The TAPE Transformer learns contextual protein representations using masked-residue pretraining and a task-specific prediction head.

  • TAPE Unirep

    Protein function

    The TAPE UniRep baseline uses a multiplicative recurrent network to represent protein sequences for downstream tasks.

  • text-embedding-3-large

    Cells and tissues

    OpenAI text embedding model that maps a text string to a 3,072-dimensional vector.

  • TranceptEVE

    Proteins and complexes

    Hybrid of a family-agnostic autoregressive transformer and family-specific alignment-based models that relies more on the alignment models as alignment depth grows, scored in ProteinGym as a zero-shot substitution baseline.

  • Tranception

    Proteins and complexes

    Autoregressive transformer protein language model that can retrieve homologous sequences at inference to predict the fitness of substitutions, multiple mutants and indels; ProteinGym scores it with and without retrieval as a zero-shot substitution baseline.

  • Transformer

    Protein function

    Transformer encoder trained from scratch on the task's sequences.

  • TREDNet

    DNA and genomes

    Two-phase CNN for enhancer prediction and variant prioritisation, developed by the group of the senior author of the comparison that evaluated it.

  • trRosettaRNA

    RNA and transcriptomes · Protein structure

    trRosettaRNA: MSA and pair representations fed into the RNAformer transformer, followed by 3D folding.

  • UCE (Universal Cell Embeddings)

    Cells and tissues

    Single-cell foundation model producing cell embeddings from protein-embedded gene tokens.

  • Uni-RNA

    RNA and transcriptomes

    Uni-RNA RNA foundation model (L8, L12 and L16 checkpoints).

  • Unirep

    Proteins and complexes

    Deep learning representation of protein sequences learned from unlabeled amino-acid sequences, on which simple models predict stability and mutant function, scored in ProteinGym as a zero-shot single-sequence substitution baseline.

  • Unirep evotuned

    Proteins and complexes

    Evo-tuned variant of UniRep, a protein sequence representation learned from unlabeled amino-acid sequences, which ProteinGym lists as using a multiple sequence alignment for evo-tuning and scores as a zero-shot substitution baseline.

  • UniSpec

    Proteins and complexes

    UniSpec attention-based fragment dictionary model (about 12M parameters).

  • UTR-LM

    DNA and genomes

    Language model pre-trained on 5' untranslated region sequence.

  • VenusREM

    Proteins and complexes

    Retrieval-enhanced protein language model that captures local amino acid interactions for mutation effect prediction, scored in ProteinGym as a zero-shot substitution baseline from alignment and structure inputs.

  • VESPA

    Proteins and complexes

    Logistic regression ensemble that predicts single amino acid variant effects without alignments from protein language model embeddings, combining predicted conservation, BLOSUM62 scores and language-model mask reconstruction probabilities; scored in ProteinGym as a zero-shot substitution baseline.

  • VespaG

    Proteins and complexes

    Missense variant effect predictor that feeds protein language model embeddings to a minimal deep learning model trained on GEMME predictions for 39 million human variants, scored in ProteinGym as a substitution baseline.

This index reflects a dated catalogue, not an exhaustive census. Source checking does not mean independent reproduction; compare results only under compatible protocols, datasets and metrics.