Source

Scaling the profile of life by function with SPIN

2026 · journal full text in PMC · Peer-reviewed

DOI: 10.1093/bioadv/vbag064 Original source

What this source contributed

Records in this release that cite this source. A record can cite several sources.

1 pipeline
1 task
1 dataset
1 evaluation
1 result
2 evidence claims

Results

Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.

Model or configuration	Metric	Value	Dataset	Evaluation
SPIN + ESM2-35M	Weighted F1	0.796 fraction	TRX	SPIN + ESM2-35M: protein function annotation

Claims

Statements this source supports, each with where in the source it was checked.

Reported F1 macro-weighted for SPIN + ESM2-35M: Printed value 0.796 (Table 1, ESM2-35M Test row, F1_m-w column)
SPIN + ESM2-35M: description: Description Classifies proteins into family-specific functional classes with an ESM2-35M backbone whose first six encoder layers are frozen, adapting a question-answering architecture to locate a domain span and classify the selected region. (Reviewed profile (2026-09-16): summary at 3 Results/3.4 Analysis of the SH3 protein family and representational augmentation across clades (paragraph 4); 3 Results/3.3 SPIN on thioredoxin, a widespread protein family (paragraph 1); architecture fact at 2 Materials and methods/2.1 SPIN architecture (paragraph 1); 2 Materials and methods/2.1 SPIN architecture (paragraph 7); description text also read at Abstract; 2 Materials and methods/2.1 SPIN architecture (layer freezing))

Models, benchmarks and other records

Pipelines (1)

SPIN + ESM2-35M

Tasks (1)

protein function annotation

Datasets (1)

Evaluations (1)

SPIN + ESM2-35M: protein function annotation

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Artifact retrieved at 2026-09-16T10:38:57.558225+00:00 Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_retrieved_at` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Artifact SHA-256 9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_sha256` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Artifact url https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12970593/fullTextXML Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_url` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Doi 10.1093/bioadv/vbag064 Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.doi` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Missing metadata: licence: reason unextracted Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.missing_metadata.licence.reason` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Publication status peer_reviewed Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.publication_status` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Retrieved at 2026-09-15T23:33:26Z Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.retrieved_at` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Scope decision included Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.scope_decision` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Url https://pmc.ncbi.nlm.nih.gov/articles/PMC12970593/ Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.url` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Version journal full text in PMC Source metadata	Scaling the profile of life by function with SPIN Original source ↗ No field-specific location recorded Version: journal full text in PMC Retrieved: 2026-09-16T10:38:57.558225+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.version` Source artifact SHA-256: `9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: discovered

Primary paper retained with its original identifier. Metadata inherited from the literature collection; individual result checks are separate.

Release history

No supporting source is linked yet.

Read original source

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: spin-protein-function-2026

areas: proteins-complexes
url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12970593/
version: journal full text in PMC
retrieved at: 2026-09-15T23:33:26Z
doi: 10.1093/bioadv/vbag064
publication status: peer_reviewed
year: 2026
artifact sha256: 9701843e93bf7fa3ead71e19693fb07d483f1022379871adfb04486783722a9d
artifact url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12970593/fullTextXML
artifact retrieved at: 2026-09-16T10:38:57.558225+00:00
scope decision: included
missing metadata: licence: reason: unextracted

Related records

Suggest a correction