Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models
bioRxiv preprint version 1, posted 2026-04-23 · Preprint
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Results
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Claims
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- Relevance of DNA language model inference throughput and maximum batch size on one A100 (Aspidova et al. 2026) to "Select an execution workflow for large-scale diagnostic genomics": Assessed by DNA language model inference throughput and maximum batch size on one A100 80 GB by sequence length (Aspidova et al. 2026 Table 2) (model-execution-20261011-source-aspidova2026-moderngena: Section 3.3-3.4; Appendix B Table 2)
Models, benchmarks and other records
Models (1)
Configurations (9)
- DNABERT-2 on one A100 80 GB (Aspidova et al. 2026)
- GENA base on one A100 80 GB (Aspidova et al. 2026)
- GENA large on one A100 80 GB (Aspidova et al. 2026)
- ModernGENA base (FA2 + autocast bf16) on one A100 80 GB (Aspidova et al. 2026)
- ModernGENA base on one A100 80 GB (Aspidova et al. 2026)
- ModernGENA large (FA2 + autocast bf16) on one A100 80 GB (Aspidova et al. 2026)
- ModernGENA large on one A100 80 GB (Aspidova et al. 2026)
- NTv2 (100M) on one A100 80 GB (Aspidova et al. 2026)
- NTv2 (250M) on one A100 80 GB (Aspidova et al. 2026)
Protocols (1)
Datasets (1)
Evaluations (9)
- DNABERT-2 (117M) inference throughput on one A100 (Aspidova et al. 2026)
- GENA base (110M) inference throughput on one A100 (Aspidova et al. 2026)
- GENA large (336M) inference throughput on one A100 (Aspidova et al. 2026)
- ModernGENA base (135M) inference throughput on one A100 (Aspidova et al. 2026)
- ModernGENA base (FA2 + autocast bf16) (135M) inference throughput on one A100 (Aspidova et al. 2026)
- ModernGENA large (377M) inference throughput on one A100 (Aspidova et al. 2026)
- ModernGENA large (FA2 + autocast bf16) (377M) inference throughput on one A100 (Aspidova et al. 2026)
- NTv2 (100M) inference throughput on one A100 (Aspidova et al. 2026)
- NTv2 (250M) inference throughput on one A100 (Aspidova et al. 2026)
Evidence
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Evidence table
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Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
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19 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Artifact SHA-256 238ab9916d54b419bf31fd79ecf146d654eb6574d3b441aa2043d39632e709fa Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Artifact url https://www.biorxiv.org/content/10.64898/2026.04.21.719816v1.full.pdf Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Doi 10.64898/2026.04.21.719816 Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
Evidence concerns1 values
| Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Hash scope bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Licence CC-BY-4.0 Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Media type application/pdf Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Publication status preprint Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Retrieved at 2026-10-11T21:39:38Z Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
| Url https://doi.org/10.64898/2026.04.21.719816 Source metadata | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models No field-specific location recorded Version: bioRxiv preprint version 1, posted 2026-04-23 | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429. |
Sources and history
Release 2026-10-23-5347695500ed · Record review: source checked
Preprint retrieved and hashed for the diagnostic genomics execution literature pass (2026-10-11).
Technical metadata and extraction receipts
Stable ID: model-execution-20261011-source-aspidova2026-moderngena
- areas
- dna-genomes
- contexts
- research
- url
- https://doi.org/10.64898/2026.04.21.719816
- artifact url
- https://www.biorxiv.org/content/10.64898/2026.04.21.719816v1.full.pdf
- version
- bioRxiv preprint version 1, posted 2026-04-23
- retrieved at
- 2026-10-11T21:39:38Z
- artifact sha256
- 238ab9916d54b419bf31fd79ecf146d654eb6574d3b441aa2043d39632e709fa
- doi
- 10.64898/2026.04.21.719816
- publication status
- preprint
- licence
- CC-BY-4.0
- media type
- application/pdf
- hash scope
- bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval; retrieved_at is the file's modification time. The pdftotext -layout text layer has SHA-256 ebaf0541c173359940737efde2c15d4ab4aa37d7cc323b3922a818feb5be6b4b. A second download at 21:43Z was refused with HTTP 429.
- evidence concerns
- source id: model-execution-20261011-source-aspidova2026-moderngena; message: Appendix B Table 2 and Figure 1 (axis 'Inference speed (tokens/s)') give throughput in tokens/s, but the printed values are inconsistent with the printed batch sizes: ModernGENA base (FA2 + autocast bf16) at L = 256 prints 552.44 tokens/s with a batch of 3,631 sequences (929,536 tokens), about 28 minutes per batch, and ModernGENA base without FA2 at L = 8192 prints 71.15 tokens/s with a batch of 92 (753,664 tokens), about 2.9 hours per batch, against a stated pretraining throughput of 1.33M tokens/s on eight A100 GPUs (Section 3.2.4). The unit or scale of the throughput column is unclear. Batch sizes share the table. Values are recorded as printed.; source locator: Appendix B Table 2 (page 9); Figure 1 (page 4); Section 3.2.4; artifact sha256: 238ab9916d54b419bf31fd79ecf146d654eb6574d3b441aa2043d39632e709fa; reviewed at: 2026-10-12T07:50:32Z; review method: automated-source-review