Source

Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction

bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF · Preprint

DOI: 10.64898/2026.08.31.748056

What this source contributed

Records in this release that cite this source. A record can cite several sources.

4 models
2 methods
23 configurations
1 benchmark
2 protocols
2 datasets
32 evaluations
64 results

Results

Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.

Value	Metric	Model or configuration	Dataset	Evaluation
0.902 unitless	Concordance index (Davis DeepDTA holdout fold)	DeepDTA with 1D conv. protein and 1D conv. drug representation	Davis holdout test fold (DeepDTA split)	DeepDTA (1D conv.; 1D conv.) on Davis
0.224 unit-unreported	MSE (Davis DeepDTA holdout fold)	DeepDTA with 1D conv. protein and 1D conv. drug representation	Davis holdout test fold (DeepDTA split)	DeepDTA (1D conv.; 1D conv.) on Davis
0.863 unitless	Concordance index (KIBA DeepDTA holdout fold)	DeepDTA with 1D conv. protein and 1D conv. drug representation	KIBA holdout test fold (DeepDTA split)	DeepDTA (1D conv.; 1D conv.) on KIBA
0.194 unit-unreported	MSE (KIBA DeepDTA holdout fold)	DeepDTA with 1D conv. protein and 1D conv. drug representation	KIBA holdout test fold (DeepDTA split)	DeepDTA (1D conv.; 1D conv.) on KIBA
0.906 unitless	Concordance index (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (8) protein and GAT-GCN drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (8); GAT-GCN) on Davis
0.175 unit-unreported	MSE (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (8) protein and GAT-GCN drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (8); GAT-GCN) on Davis
0.901 unitless	Concordance index (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (8) protein and GCN drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (8); GCN) on KIBA
0.128 unit-unreported	MSE (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (8) protein and GCN drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (8); GCN) on KIBA
0.907 unitless	Concordance index (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (16) protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (16); GAT) on Davis
0.176 unit-unreported	MSE (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (16) protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (16); GAT) on Davis
0.906 unitless	Concordance index (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (16) protein and GCN drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (16); GCN) on Davis
0.174 unit-unreported	MSE (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (16) protein and GCN drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (16); GCN) on Davis
0.888 unitless	Concordance index (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (16) protein and GIN drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (16); GIN) on KIBA
0.145 unit-unreported	MSE (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (16) protein and GIN drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (16); GIN) on KIBA
0.872 unitless	Concordance index (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (24) protein and GAT drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (24); GAT) on KIBA
0.173 unit-unreported	MSE (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (24) protein and GAT drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (24); GAT) on KIBA
0.903 unitless	Concordance index (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (32) protein and GAT-GCN drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (32); GAT-GCN) on KIBA
0.125 unit-unreported	MSE (KIBA DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (32) protein and GAT-GCN drug representation	KIBA holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (32); GAT-GCN) on KIBA
0.909 unitless	Concordance index (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (32) protein and GIN drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (32); GIN) on Davis
0.172 unit-unreported	MSE (Davis DeepDTA holdout fold)	DeepGraphDTA with 1D conv. (32) protein and GIN drug representation	Davis holdout test fold (DeepDTA split)	DeepGraphDTA (1D conv. (32); GIN) on Davis
0.889 unitless	Concordance index (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT-GCN drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT-GCN) on Davis
0.227 unit-unreported	MSE (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT-GCN drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT-GCN) on Davis
0.890 unitless	Concordance index (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT-GCN drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT-GCN) on KIBA
0.145 unit-unreported	MSE (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT-GCN drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT-GCN) on KIBA
0.893 unitless	Concordance index (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT) on Davis
0.255 unit-unreported	MSE (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT) on Davis
0.866 unitless	Concordance index (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT) on KIBA
0.178 unit-unreported	MSE (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GAT drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GAT) on KIBA
0.880 unitless	Concordance index (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GCN drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GCN) on Davis
0.237 unit-unreported	MSE (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GCN drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GCN) on Davis
0.892 unitless	Concordance index (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GCN drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GCN) on KIBA
0.144 unit-unreported	MSE (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GCN drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GCN) on KIBA
0.897 unitless	Concordance index (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GIN drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GIN) on Davis
0.199 unit-unreported	MSE (Davis DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GIN drug representation	Davis holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GIN) on Davis
0.884 unitless	Concordance index (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GIN drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GIN) on KIBA
0.149 unit-unreported	MSE (KIBA DeepDTA holdout fold)	GraphDTA with 1D conv. protein and GIN drug representation	KIBA holdout test fold (DeepDTA split)	GraphDTA (1D conv.; GIN) on KIBA
0.870 unitless	Concordance index (Davis DeepDTA holdout fold)	KronRLS with Similarity vector protein and Similarity vector drug representation	Davis holdout test fold (DeepDTA split)	KronRLS (Similarity vector; Similarity vector) on Davis
0.359 unit-unreported	MSE (Davis DeepDTA holdout fold)	KronRLS with Similarity vector protein and Similarity vector drug representation	Davis holdout test fold (DeepDTA split)	KronRLS (Similarity vector; Similarity vector) on Davis
0.782 unitless	Concordance index (KIBA DeepDTA holdout fold)	KronRLS with Similarity vector protein and Similarity vector drug representation	KIBA holdout test fold (DeepDTA split)	KronRLS (Similarity vector; Similarity vector) on KIBA
0.411 unit-unreported	MSE (KIBA DeepDTA holdout fold)	KronRLS with Similarity vector protein and Similarity vector drug representation	KIBA holdout test fold (DeepDTA split)	KronRLS (Similarity vector; Similarity vector) on KIBA
0.898 unitless	Concordance index (Davis DeepDTA holdout fold)	PGraphDTA with ESM2 650M protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	PGraphDTA (ESM2 650M; GAT) on Davis
0.206 unit-unreported	MSE (Davis DeepDTA holdout fold)	PGraphDTA with ESM2 650M protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	PGraphDTA (ESM2 650M; GAT) on Davis
0.872 unitless	Concordance index (KIBA DeepDTA holdout fold)	PGraphDTA with ESM2 650M protein and GAT drug representation	KIBA holdout test fold (DeepDTA split)	PGraphDTA (ESM2 650M; GAT) on KIBA
0.160 unit-unreported	MSE (KIBA DeepDTA holdout fold)	PGraphDTA with ESM2 650M protein and GAT drug representation	KIBA holdout test fold (DeepDTA split)	PGraphDTA (ESM2 650M; GAT) on KIBA
0.910 unitless	Concordance index (Davis DeepDTA holdout fold)	PLM-GraphDTA with ESMC 600M protein and GAT-GCN drug representation	Davis holdout test fold (DeepDTA split)	PLM-GraphDTA (ESMC 600M; GAT-GCN) on Davis
0.169 unit-unreported	MSE (Davis DeepDTA holdout fold)	PLM-GraphDTA with ESMC 600M protein and GAT-GCN drug representation	Davis holdout test fold (DeepDTA split)	PLM-GraphDTA (ESMC 600M; GAT-GCN) on Davis
0.908 unitless	Concordance index (Davis DeepDTA holdout fold)	PLM-GraphDTA with ESMC 600M protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	PLM-GraphDTA (ESMC 600M; GAT) on Davis
0.174 unit-unreported	MSE (Davis DeepDTA holdout fold)	PLM-GraphDTA with ESMC 600M protein and GAT drug representation	Davis holdout test fold (DeepDTA split)	PLM-GraphDTA (ESMC 600M; GAT) on Davis
0.906 unitless	Concordance index (Davis DeepDTA holdout fold)	PLM-GraphDTA with ESMC 600M protein and GCN drug representation	Davis holdout test fold (DeepDTA split)	PLM-GraphDTA (ESMC 600M; GCN) on Davis
0.167 unit-unreported	MSE (Davis DeepDTA holdout fold)	PLM-GraphDTA with ESMC 600M protein and GCN drug representation	Davis holdout test fold (DeepDTA split)	PLM-GraphDTA (ESMC 600M; GCN) on Davis

Models, benchmarks and other records

Models (4)

Methods (2)

Configurations (23)

Benchmarks (1)

Davis and KIBA drug-target affinity benchmark (DeepDTA split)

Protocols (2)

Datasets (2)

Evaluations (32)

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

25 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
attributes.artifact_sha256 11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163 Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.artifact_sha256` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Artifact url https://www.biorxiv.org/content/10.64898/2026.08.31.748056v1.full.pdf Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.artifact_url` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Code url https://github.com/matija-marijan/PLM-GraphDTA Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.code_url` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Doi 10.64898/2026.08.31.748056 Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.doi` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Evidence concerns 1 values source id lit-interactions-20261011-plmdta-source-marijan2026 message Table 3 KIBA rows KronRLS, SimBoost and DeepDTA equal the values printed in Ozturk et al. 2018, while the proposed models are 5-seed means; the rows may not share a training run or protocol. Do not compare these three rows against the proposed models automatically. source locator Table 3, rows KronRLS, SimBoost, DeepDTA artifact sha256 11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163 reviewed at 2026-10-11T00:00:00Z review method ai-assisted-source-review Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.evidence_concerns` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Licence CC-BY-NC-4.0 Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.licence` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Limitations 5 values bioRxiv adds a per-request banner, so the PDF hash describes this one retrieval. Values were read from the pdftotext (poppler 26.08.0) layout text layer, SHA-256 e9b9dff90c731fe69f34a8649daf95d4f69449b1b8143da9ea7c72af4e11edd4. The PDF is not archived in the repository. Tables 2 and 3 print one PLM per drug backbone (the 5-fold CV winner); the per-PLM comparison (ESM2 8M/150M/650M, ESMC 300M/600M, DeepFRI, ProstT5) is in Appendix D figures and was not read. Cold-start results (Figures 4 and 5) are figures only and were not read. Italic and bold marking of best values is not carried by the text layer. Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.limitations` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Media type application/pdf Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.media_type` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Publication status preprint Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.publication_status` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Retrieved at 2026-10-11T21:27:40Z Source metadata	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ No field-specific location recorded Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.retrieved_at` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

Primary source retrieved and hashed for the 2026-10-11 microbial and interactions literature pass.

Release history

No supporting source is linked yet.

Read original source

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: lit-interactions-20261011-plmdta-source-marijan2026

areas: molecular-interactions
contexts: research
url: https://doi.org/10.64898/2026.08.31.748056
artifact url: https://www.biorxiv.org/content/10.64898/2026.08.31.748056v1.full.pdf
version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF
retrieved at: 2026-10-11T21:27:40Z
artifact sha256: 11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163
doi: 10.64898/2026.08.31.748056
publication status: preprint
licence: CC-BY-NC-4.0
media type: application/pdf
code url: https://github.com/matija-marijan/PLM-GraphDTA
limitations: bioRxiv adds a per-request banner, so the PDF hash describes this one retrieval.; Values were read from the pdftotext (poppler 26.08.0) layout text layer, SHA-256 e9b9dff90c731fe69f34a8649daf95d4f69449b1b8143da9ea7c72af4e11edd4. The PDF is not archived in the repository.; Tables 2 and 3 print one PLM per drug backbone (the 5-fold CV winner); the per-PLM comparison (ESM2 8M/150M/650M, ESMC 300M/600M, DeepFRI, ProstT5) is in Appendix D figures and was not read.; Cold-start results (Figures 4 and 5) are figures only and were not read.; Italic and bold marking of best values is not carried by the text layer.
evidence concerns: source id: lit-interactions-20261011-plmdta-source-marijan2026; message: Table 3 KIBA rows KronRLS, SimBoost and DeepDTA equal the values printed in Ozturk et al. 2018, while the proposed models are 5-seed means; the rows may not share a training run or protocol. Do not compare these three rows against the proposed models automatically.; source locator: Table 3, rows KronRLS, SimBoost, DeepDTA; artifact sha256: 11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163; reviewed at: 2026-10-11T00:00:00Z; review method: ai-assisted-source-review
review: method: source-hash-verification; method note: PDF re-downloaded; the per-request bioRxiv banner changes the PDF hash, so the pdftotext -layout text layer was rehashed instead and matches the recorded text-layer hash.; reviewer: claude; reviewer note: Claude review agent reviewer-mi-2, independent of the extractor lit-microbial-interactions; no human review claimed; date: 2026-10-11

Related records

Suggest a correction