Evaluation

KronRLS (Similarity vector; Similarity vector) on KIBA

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 2 results. Different protocols are not a single leaderboard.

Protocol: KIBA drug-target affinity, DeepDTA holdout fold · Dataset: KIBA holdout test fold (DeepDTA split)

Sorted by Concordance index (KIBA DeepDTA holdout fold) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Concordance index (KIBA DeepDTA holdout fold)	MSE (KIBA DeepDTA holdout fold)
KronRLS with Similarity vector protein and Similarity vector drug representationEvaluation	0.782	0.411

All 2 result rows with coverage, uncertainty and sources

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: KronRLS with Similarity vector protein and Similarity vector drug representation	Protocol: KIBA drug-target affinity, DeepDTA holdout fold Dataset: KIBA holdout test fold (DeepDTA split)	0.782 Concordance index (KIBA DeepDTA holdout fold) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Evidence concern: excluded from comparisons Table 3 KIBA rows KronRLS, SimBoost and DeepDTA equal the values printed in Ozturk et al. 2018, while the proposed models are 5-seed means; the rows may not share a training run or protocol. Do not compare these three rows against the proposed models automatically.Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction · Table 3, rows KronRLS, SimBoost, DeepDTA Methods, coverage and source KronRLS (Similarity vector; Similarity vector) on KIBA lit-interactions-20261011-plmdta-protocol-kiba-deepdta-holdout Aggregation: Not reported Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction · Table 3, row 'KronRLS' with protein 'Similarity vector' and drug 'Similarity vector', column 'CI' (text-layer line 583)
Configuration: KronRLS with Similarity vector protein and Similarity vector drug representation	Protocol: KIBA drug-target affinity, DeepDTA holdout fold Dataset: KIBA holdout test fold (DeepDTA split)	0.411 MSE (KIBA DeepDTA holdout fold) unit-unreported · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Evidence concern: excluded from comparisons Table 3 KIBA rows KronRLS, SimBoost and DeepDTA equal the values printed in Ozturk et al. 2018, while the proposed models are 5-seed means; the rows may not share a training run or protocol. Do not compare these three rows against the proposed models automatically.Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction · Table 3, rows KronRLS, SimBoost, DeepDTA Methods, coverage and source KronRLS (Similarity vector; Similarity vector) on KIBA lit-interactions-20261011-plmdta-protocol-kiba-deepdta-holdout Aggregation: Not reported Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction · Table 3, row 'KronRLS' with protein 'Similarity vector' and drug 'Similarity vector', column 'MSE' (text-layer line 583)

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

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Evaluation procedure

KIBA drug-target affinity, DeepDTA holdout fold

Configuration: KronRLS with Similarity vector protein and Similarity vector drug representation
Protocol: KIBA drug-target affinity, DeepDTA holdout fold
Dataset: KIBA holdout test fold (DeepDTA split)

origin: Evaluation origin not reported
configuration: Primary source as retrieved 2026-10-11
protocol id: lit-interactions-20261011-plmdta-protocol-kiba-deepdta-holdout
dataset version: DeepDTA split
split: Holdout test fold
population: Not reported
inputs: Protein sequence (padded or truncated to 1000 residues) and drug SMILES or graph
adaptation: Not reported
metric implementation: CI and MSE as printed
aggregation: Not reported
budget: Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split: Holdout test fold
Adaptation: Not reported
Scoring implementation: CI and MSE as printed

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Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Comparison: adaptation Not reported Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	missing or unspecified No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: aggregation Not reported Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	missing or unspecified No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: budget Not reported Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	missing or unspecified No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: dataset version DeepDTA split Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	not individually reviewed No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: inputs Protein sequence (padded or truncated to 1000 residues) and drug SMILES or graph Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	not individually reviewed No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: metric implementation CI and MSE as printed Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	not individually reviewed No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.metric_implementation` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: population Not reported Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	missing or unspecified No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.population` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: protocol id lit-interactions-20261011-plmdta-protocol-kiba-deepdta-holdout Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	not individually reviewed No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.protocol_id` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: split Holdout test fold Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	not individually reviewed No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.comparison.split` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Origin unreported Context-only references	Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction Original source ↗ Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector' Version: bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF Retrieved: 2026-10-11T21:27:40Z	missing or unspecified No individual claim review recorded unreported Source has a recorded evidence concern. Consult its source page before using the claim. Audit details Field: `attributes.origin` Source artifact SHA-256: `11b88d5ab2964b581430454d0d9e7848739819d52ec2e338e2a6412cbd259163` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

Comprehensive Evaluation of Protein Language Model Embeddings for Drug-Target Affinity Prediction · Original source · bioRxiv 10.64898/2026.08.31.748056v1 (posted 2026-09-03); 24-page PDF

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Technical metadata and extraction receipts

Stable ID: lit-interactions-20261011-plmdta-eval-kronrls-similarity-vector-similarity-vector-kiba

areas: molecular-interactions
contexts: research
origin: unreported
protocol: lit-interactions-20261011-plmdta-protocol-kiba-deepdta-holdout
version: Primary source as retrieved 2026-10-11
comparison: protocol id: lit-interactions-20261011-plmdta-protocol-kiba-deepdta-holdout; dataset version: DeepDTA split; split: Holdout test fold; population: Not reported; inputs: Protein sequence (padded or truncated to 1000 residues) and drug SMILES or graph; adaptation: Not reported; metric implementation: CI and MSE as printed; aggregation: Not reported; budget: Not reported
source locator: Table 3 row 'KronRLS', protein 'Similarity vector', drug 'Similarity vector'
missing metadata: comparison.adaptation: reason: unreported; note: Baseline training not described. Printed values identical to Ozturk et al. 2018 (arXiv 1801.10193v2) KIBA table; likely copied, not rerun.; comparison.aggregation: reason: unreported; comparison.budget: reason: unreported; comparison.population: reason: unreported

Related records

system: KronRLS with Similarity vector protein and Similarity vector drug representation
assessment: KIBA drug-target affinity, DeepDTA holdout fold
data: KIBA holdout test fold (DeepDTA split)
evaluation: KronRLS Similarity vector Similarity vector KIBA CI
evaluation: KronRLS Similarity vector Similarity vector KIBA MSE

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