Source

GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models

bioRxiv preprint version 2, posted 2026-08-11 · Preprint

DOI: 10.64898/2026.02.19.706811

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Records in this release that cite this source. A record can cite several sources.

1 model
10 configurations
1 benchmark
37 protocols
20 datasets
139 evaluations
552 results
9 evidence claims

Results

Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.

Value	Metric	Model or configuration	Dataset	Evaluation
0.1071 unitless	AUPRC (zero-shot; cosine similarity of embeddings at the SNV position)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-embedding)
0.3782 unitless	AUPRC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-embedding)
0.3788 unitless	AUPRC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-embedding)
0.5446 unitless	AUROC (zero-shot; cosine similarity of embeddings at the SNV position)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-embedding)
0.7724 unitless	AUROC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-embedding)
0.7798 unitless	AUROC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-embedding)
0.1397 unitless	AUPRC (zero-shot; masked log-likelihood ratio)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-mlm-llr)
0.6598 unitless	AUROC (zero-shot; masked log-likelihood ratio)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Disease test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Disease (zs-mlm-llr)
0.0775 unitless	AUPRC (zero-shot; cosine similarity of embeddings at the SNV position)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-embedding)
0.0676 unitless	AUPRC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-embedding)
0.0692 unitless	AUPRC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-embedding)
0.5371 unitless	AUROC (zero-shot; cosine similarity of embeddings at the SNV position)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-embedding)
0.4729 unitless	AUROC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-embedding)
0.4794 unitless	AUROC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-embedding)
0.0679 unitless	AUPRC (zero-shot; masked log-likelihood ratio)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-mlm-llr)
0.4886 unitless	AUROC (zero-shot; masked log-likelihood ratio)	Caduceus-Ps (zero-shot, GFMBench-API)	Bend Variant Effects Expression test set (GFMBench-API)	Caduceus-Ps on GFMBench-API Bend Variant Effects Expression (zs-mlm-llr)
0.2025 unitless	AUPRC (zero-shot; cosine similarity of embeddings at the SNV position)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-embedding)
0.2910 unitless	AUPRC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-embedding)
0.2986 unitless	AUPRC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-embedding)
0.4690 unitless	AUROC (zero-shot; cosine similarity of embeddings at the SNV position)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-embedding)
0.5553 unitless	AUROC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-embedding)
0.5631 unitless	AUROC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-embedding)
0.2180 unitless	AUPRC (zero-shot; masked log-likelihood ratio)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-mlm-llr)
0.4832 unitless	AUROC (zero-shot; masked log-likelihood ratio)	Caduceus-Ps (zero-shot, GFMBench-API)	BRCA1 test set (GFMBench-API)	Caduceus-Ps on GFMBench-API BRCA1 (zs-mlm-llr)
0.9581 unitless	AUPRC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	ClinVar Indel Pathogenicity test set (GFMBench-API)	Caduceus-Ps on GFMBench-API ClinVar Indel Pathogenicity (zs-embedding)
0.9585 unitless	AUPRC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	ClinVar Indel Pathogenicity test set (GFMBench-API)	Caduceus-Ps on GFMBench-API ClinVar Indel Pathogenicity (zs-embedding)
0.7080 unitless	AUROC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	ClinVar Indel Pathogenicity test set (GFMBench-API)	Caduceus-Ps on GFMBench-API ClinVar Indel Pathogenicity (zs-embedding)
0.7100 unitless	AUROC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	ClinVar Indel Pathogenicity test set (GFMBench-API)	Caduceus-Ps on GFMBench-API ClinVar Indel Pathogenicity (zs-embedding)
0.9012 unitless	Accuracy (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Promoter All test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Promoter All (supervised)
0.9601 unitless	AUPRC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Promoter All test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Promoter All (supervised)
0.9643 unitless	AUROC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Promoter All test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Promoter All (supervised)
0.8024 unitless	MCC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Promoter All test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Promoter All (supervised)
0.8963 unitless	Accuracy (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Splice Site test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Splice Site (supervised)
0.9174 unitless	AUPRC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Splice Site test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Splice Site (supervised)
0.9551 unitless	AUROC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Splice Site test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Splice Site (supervised)
0.8207 unitless	MCC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Splice Site test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Splice Site (supervised)
0.8056 unitless	Accuracy (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Transcription Factor test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Transcription Factor (supervised)
0.8875 unitless	AUPRC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Transcription Factor test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Transcription Factor (supervised)
0.8909 unitless	AUROC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Transcription Factor test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Transcription Factor (supervised)
0.6140 unitless	MCC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	GUE Transcription Factor test set (GFMBench-API)	Caduceus-Ps on GFMBench-API GUE Transcription Factor (supervised)
0.0861 unitless	AUPRC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	LOL-EVE test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LOL-EVE (zs-embedding)
0.0863 unitless	AUPRC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	LOL-EVE test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LOL-EVE (zs-embedding)
0.5242 unitless	AUROC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	LOL-EVE test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LOL-EVE (zs-embedding)
0.5216 unitless	AUROC (zero-shot; L2 distance of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	LOL-EVE test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LOL-EVE (zs-embedding)
0.6286 unitless	Accuracy (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	LRB Variant Effect Causal eQTL test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LRB Variant Effect Causal eQTL (supervised)
0.6856 unitless	AUPRC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	LRB Variant Effect Causal eQTL test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LRB Variant Effect Causal eQTL (supervised)
0.6792 unitless	AUROC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	LRB Variant Effect Causal eQTL test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LRB Variant Effect Causal eQTL (supervised)
0.2838 unitless	MCC (test set)	Caduceus-Ps (full fine-tuning, GFMBench-API)	LRB Variant Effect Causal eQTL test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LRB Variant Effect Causal eQTL (supervised)
0.0022 unitless	AUPRC (zero-shot; cosine similarity of embeddings at the SNV position)	Caduceus-Ps (zero-shot, GFMBench-API)	LRB Variant Effect OMIM test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LRB Variant Effect OMIM (zs-embedding)
0.0019 unitless	AUPRC (zero-shot; cosine similarity of reference and alternate sequence embeddings)	Caduceus-Ps (zero-shot, GFMBench-API)	LRB Variant Effect OMIM test set (GFMBench-API)	Caduceus-Ps on GFMBench-API LRB Variant Effect OMIM (zs-embedding)

Claims

Statements this source supports, each with where in the source it was checked.

Relevance of GFMBench-API BRCA1, zs-ar-llr to "Interpret BRCA1/BRCA2 germline variants": Assessed by GFMBench-API BRCA1, zs-ar-llr (lit-genomics-20261011-gfmbench-source-larey2026: Table 5, task 'BRCA1'; Supplementary Note, BRCA1 task)
Relevance of GFMBench-API BRCA1, zs-embedding to "Interpret BRCA1/BRCA2 germline variants": Assessed by GFMBench-API BRCA1, zs-embedding (lit-genomics-20261011-gfmbench-source-larey2026: Table 3, task 'BRCA1'; Supplementary Note, BRCA1 task)
Relevance of GFMBench-API BRCA1, zs-mlm-llr to "Interpret BRCA1/BRCA2 germline variants": Assessed by GFMBench-API BRCA1, zs-mlm-llr (lit-genomics-20261011-gfmbench-source-larey2026: Table 4, task 'BRCA1'; Supplementary Note, BRCA1 task)
Relevance of GFMBench-API TraitGym Complex, zs-ar-llr to "Select regulatory variants and genes for functional follow-up": Assessed by GFMBench-API TraitGym Complex, zs-ar-llr (lit-genomics-20261011-gfmbench-source-larey2026: Table 5, task 'TraitGym Complex'; appendix task description)
Relevance of GFMBench-API TraitGym Complex, zs-embedding to "Select regulatory variants and genes for functional follow-up": Assessed by GFMBench-API TraitGym Complex, zs-embedding (lit-genomics-20261011-gfmbench-source-larey2026: Table 3, task 'TraitGym Complex'; appendix task description)
Relevance of GFMBench-API TraitGym Complex, zs-mlm-llr to "Select regulatory variants and genes for functional follow-up": Assessed by GFMBench-API TraitGym Complex, zs-mlm-llr (lit-genomics-20261011-gfmbench-source-larey2026: Table 4, task 'TraitGym Complex'; appendix task description)
Relevance of GFMBench-API TraitGym Mendelian, zs-ar-llr to "Select regulatory variants and genes for functional follow-up": Assessed by GFMBench-API TraitGym Mendelian, zs-ar-llr (lit-genomics-20261011-gfmbench-source-larey2026: Table 5, task 'TraitGym Mendelian'; appendix task description)
Relevance of GFMBench-API TraitGym Mendelian, zs-embedding to "Select regulatory variants and genes for functional follow-up": Assessed by GFMBench-API TraitGym Mendelian, zs-embedding (lit-genomics-20261011-gfmbench-source-larey2026: Table 3, task 'TraitGym Mendelian'; appendix task description)
Relevance of GFMBench-API TraitGym Mendelian, zs-mlm-llr to "Select regulatory variants and genes for functional follow-up": Assessed by GFMBench-API TraitGym Mendelian, zs-mlm-llr (lit-genomics-20261011-gfmbench-source-larey2026: Table 4, task 'TraitGym Mendelian'; appendix task description)

Models, benchmarks and other records

Models (1)

DNABERT

Configurations (10)

Benchmarks (1)

GFMBench-API

Protocols (37)

Datasets (20)

Evaluations (139)

Evidence

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Evidence table

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23 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
attributes.artifact_sha256 df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72 Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_sha256` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Artifact url https://www.biorxiv.org/content/10.64898/2026.02.19.706811v2.full.pdf Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_url` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Doi 10.64898/2026.02.19.706811 Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.doi` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Licence CC-BY-4.0 Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.licence` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Limitations 2 values Preprint, not peer reviewed. Authors are at NVIDIA, which distributes the BioNeMo implementation of Evo2 used here; no model in the tables was developed by the authors. Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.limitations` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Media type application/pdf Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.media_type` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Publication status preprint Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.publication_status` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Retrieved at 2026-10-11T00:44:58Z Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.retrieved_at` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Review: date 2026-10-11 Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.review.date` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Review: method note Artifact re-retrieved or unpacked and SHA-256 matched. Source metadata	GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models Original source ↗ No field-specific location recorded Version: bioRxiv preprint version 2, posted 2026-08-11 Retrieved: 2026-10-11T00:44:58Z	catalogued No individual claim review recorded Audit details Field: `attributes.review.method_note` Source artifact SHA-256: `df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

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Stable ID: lit-genomics-20261011-gfmbench-source-larey2026

areas: dna-genomes
contexts: research
url: https://doi.org/10.64898/2026.02.19.706811
artifact url: https://www.biorxiv.org/content/10.64898/2026.02.19.706811v2.full.pdf
version: bioRxiv preprint version 2, posted 2026-08-11
retrieved at: 2026-10-11T00:44:58Z
artifact sha256: df9934c88ee245b1e19e155174169d6b6da57ae07c1a04bbea7115423facdf72
doi: 10.64898/2026.02.19.706811
publication status: preprint
licence: CC-BY-4.0
media type: application/pdf
limitations: Preprint, not peer reviewed.; Authors are at NVIDIA, which distributes the BioNeMo implementation of Evo2 used here; no model in the tables was developed by the authors.
review: method: source-hash-verification; method note: Artifact re-retrieved or unpacked and SHA-256 matched.; reviewer: claude; reviewer note: Claude review agent reviewer-gen-3, independent of the extractor lit-genomics; no human review claimed; date: 2026-10-11

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