Source

Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods

Nature Genetics · 2023 · Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) · Peer-reviewed

DOI: 10.1038/s41588-023-01465-0 Original source

What this source contributed

Records in this release that cite this source. A record can cite several sources.

51 configurations
2 benchmarks
6 protocols
95 dataset subsets
244 evaluations
462 results

Results

Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.

Value	Metric	Model or configuration	Dataset	Evaluation
0.662203060682712 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar all stop-gains; zero-shot)	50 bp rule for nonsense-mediated decay	ClinVar stop-gain variants, pathogenic vs benign (Brandes et al. 2023)	50bp rule on all stop-gains (Brandes et al. 2023)
0.586435752317274 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar all in-frame indels; zero-shot)	Pairwise alignment score (indel baseline)	ClinVar in-frame indels, pathogenic vs benign (Brandes et al. 2023)	Alignment on all in-frame indels (Brandes et al. 2023)
0.946487950167752 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	BayesDel (no AF) (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and BayesDel (no AF) (Brandes et al. 2023)	BayesDel (no AF) on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.947999495980187 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	BayesDel (no AF) (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and BayesDel (no AF) (Brandes et al. 2023)	BayesDel (no AF) on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.980335926822551 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	BayesDel (no AF) (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and BayesDel (no AF) (Brandes et al. 2023)	BayesDel (no AF) on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.978236677449422 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	BayesDel (no AF) (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and BayesDel (no AF) (Brandes et al. 2023)	BayesDel (no AF) on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.974160079812455 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	BayesDel (with AF) (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and BayesDel (with AF) (Brandes et al. 2023)	BayesDel (with AF) on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.976738413063963 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	BayesDel (with AF) (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and BayesDel (with AF) (Brandes et al. 2023)	BayesDel (with AF) on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.992324635108394 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	BayesDel (with AF) (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and BayesDel (with AF) (Brandes et al. 2023)	BayesDel (with AF) on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.992291705912356 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	BayesDel (with AF) (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and BayesDel (with AF) (Brandes et al. 2023)	BayesDel (with AF) on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.581684812122288 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar all in-frame indels; zero-shot)	BlastP score (indel baseline)	ClinVar in-frame indels, pathogenic vs benign (Brandes et al. 2023)	BlastP on all in-frame indels (Brandes et al. 2023)
0.539298346796558 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	ClinVar missense variants scored by both ESM1b and bStatistic (Brandes et al. 2023)	bStatistic on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.560656139972137 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	ClinVar missense variants scored by both ESM1b and bStatistic (Brandes et al. 2023)	bStatistic on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.543147322509533 unitless	AUPRC (balanced PRC-AUC: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	ClinVar missense pathogenic vs benign, primary isoforms (Brandes et al. 2023, from the EVE portal)	bStatistic on ClinVar missense, variants scored by all 19 methods (Brandes et al. 2023)
0.562825728589234 unitless	AUROC (global ROC-AUC over all variants; zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	ClinVar missense pathogenic vs benign, primary isoforms (Brandes et al. 2023, from the EVE portal)	bStatistic on ClinVar missense, variants scored by all 19 methods (Brandes et al. 2023)
0.580555088476076 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	HGMD/gnomAD missense variants scored by both ESM1b and bStatistic (Brandes et al. 2023)	bStatistic on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.581782069823495 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	HGMD/gnomAD missense variants scored by both ESM1b and bStatistic (Brandes et al. 2023)	bStatistic on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.534115963003298 unitless	AUPRC (balanced PRC-AUC: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	HGMD disease-causing vs gnomAD common missense variants, primary isoforms (Brandes et al. 2023)	bStatistic on HGMD/gnomAD missense, variants scored by all 19 methods (Brandes et al. 2023)
0.535573966000815 unitless	AUROC (global ROC-AUC over all variants; zero-shot)	bStatistic (Brandes et al. 2023 clinical benchmarks)	HGMD disease-causing vs gnomAD common missense variants, primary isoforms (Brandes et al. 2023)	bStatistic on HGMD/gnomAD missense, variants scored by all 19 methods (Brandes et al. 2023)
0.835780384285267 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar all in-frame indels; zero-shot)	CADD in-frame indel scores (Brandes et al. 2023)	ClinVar in-frame indels, pathogenic vs benign (Brandes et al. 2023)	CADD on all in-frame indels (Brandes et al. 2023)
0.871368321583246 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	CADD (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and CADD (Brandes et al. 2023)	CADD on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.896607058523481 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	CADD (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and CADD (Brandes et al. 2023)	CADD on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.671464 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar deletion-insertions; zero-shot)	CADD in-frame indel scores (Brandes et al. 2023)	ClinVar in-frame deletion-insertions (Brandes et al. 2023)	CADD on deletion-insertions (Brandes et al. 2023)
0.848141 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar deletions; zero-shot)	CADD in-frame indel scores (Brandes et al. 2023)	ClinVar in-frame deletions (Brandes et al. 2023)	CADD on deletions (Brandes et al. 2023)
0.911693982661796 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	CADD (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and CADD (Brandes et al. 2023)	CADD on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.917203727649111 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	CADD (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and CADD (Brandes et al. 2023)	CADD on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.756837 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar insertions; zero-shot)	CADD in-frame indel scores (Brandes et al. 2023)	ClinVar in-frame insertions (Brandes et al. 2023)	CADD on insertions (Brandes et al. 2023)
0.978923571976287 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	ClinPred (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and ClinPred (Brandes et al. 2023)	ClinPred on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.98197198740626 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	ClinPred (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and ClinPred (Brandes et al. 2023)	ClinPred on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.980436885355161 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	ClinPred (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and ClinPred (Brandes et al. 2023)	ClinPred on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.982613471236555 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	ClinPred (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and ClinPred (Brandes et al. 2023)	ClinPred on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.723404287845123 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	DANN (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and DANN (Brandes et al. 2023)	DANN on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.779479521810876 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	DANN (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and DANN (Brandes et al. 2023)	DANN on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.792631936110773 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	DANN (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and DANN (Brandes et al. 2023)	DANN on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.838630621790844 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	DANN (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and DANN (Brandes et al. 2023)	DANN on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.917908571392221 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	DEOGEN2 (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and DEOGEN2 (Brandes et al. 2023)	DEOGEN2 on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.912478948636199 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	DEOGEN2 (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and DEOGEN2 (Brandes et al. 2023)	DEOGEN2 on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.961594714736039 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	DEOGEN2 (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and DEOGEN2 (Brandes et al. 2023)	DEOGEN2 on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.958144497005041 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	DEOGEN2 (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and DEOGEN2 (Brandes et al. 2023)	DEOGEN2 on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.501679198720091 unitless	AUROC (ROC-AUC, pathogenic versus benign ClinVar all in-frame indels; zero-shot)	Levenshtein	ClinVar in-frame indels, pathogenic vs benign (Brandes et al. 2023)	Edit distance on all in-frame indels (Brandes et al. 2023)
0.893881911468068 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	Eigen (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and Eigen (Brandes et al. 2023)	Eigen on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.902556806623812 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	Eigen (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and Eigen (Brandes et al. 2023)	Eigen on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.910438720140354 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	Eigen (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and Eigen (Brandes et al. 2023)	Eigen on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.913137960845037 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	Eigen (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and Eigen (Brandes et al. 2023)	Eigen on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.875445861039715 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	Eigen-PC (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and Eigen-PC (Brandes et al. 2023)	Eigen-PC on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.887878772403633 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	Eigen-PC (Brandes et al. 2023 head-to-head comparison)	ClinVar missense variants scored by both ESM1b and Eigen-PC (Brandes et al. 2023)	Eigen-PC on ClinVar missense, head to head against ESM1b (Brandes et al. 2023)
0.902808504951316 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	Eigen-PC (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and Eigen-PC (Brandes et al. 2023)	Eigen-PC on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.90771824730958 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	Eigen-PC (Brandes et al. 2023 head-to-head comparison)	HGMD/gnomAD missense variants scored by both ESM1b and Eigen-PC (Brandes et al. 2023)	Eigen-PC on HGMD/gnomAD missense, head to head against ESM1b (Brandes et al. 2023)
0.906188422497614 unitless	AUPRC (balanced PRC-AUC over the variants both methods score: mean over 100 random downsamples to equal pathogenic and benign counts (80% of the minority class); zero-shot)	ESM1b (Brandes et al. 2023 clinical benchmarks)	ClinVar missense variants scored by both ESM1b and BayesDel (no AF) (Brandes et al. 2023)	ESM1b on ClinVar missense, head to head against BayesDel (no AF) (Brandes et al. 2023)
0.905875955210954 unitless	AUROC (global ROC-AUC over the variants both methods score; zero-shot)	ESM1b (Brandes et al. 2023 clinical benchmarks)	ClinVar missense variants scored by both ESM1b and BayesDel (no AF) (Brandes et al. 2023)	ESM1b on ClinVar missense, head to head against BayesDel (no AF) (Brandes et al. 2023)

Models, benchmarks and other records

Configurations (51)

Benchmarks (2)

Protocols (6)

Dataset subsets (95)

Evaluations (244)

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Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Archive member artifacts/brandes2023-supplementary-table-2.xlsx.gz Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.archive_member` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
attributes.archive_sha256 00efa2694f9fcb43f7dd346a24838866449d301c565ac4e26f6fa5c86d5bec64 Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.archive_sha256` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
attributes.artifact_sha256 093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2 Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_sha256` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
Artifact url https://static-content.springer.com/esm/art%3A10.1038%2Fs41588-023-01465-0/MediaObjects/41588_2023_1465_MOESM3_ESM.xlsx Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_url` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
Doi 10.1038/s41588-023-01465-0 Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.doi` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
Licence CC BY 4.0 Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.licence` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
Media type application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.media_type` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
Publication status peer_reviewed Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.publication_status` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
Retrieved at 2026-10-14T12:03:21Z Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.retrieved_at` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact
attributes.review.artifact_sha256 093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2 Source metadata	Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods Original source ↗ No field-specific location recorded Version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10) Retrieved: 2026-10-14T12:03:21Z	catalogued No individual claim review recorded Audit details Field: `attributes.review.artifact_sha256` Source artifact SHA-256: `093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2` Hash scope: Hash scope not separately documented; inspect source record Archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

Publisher supplementary workbook (41588_2023_1465_MOESM3_ESM.xlsx).

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Stable ID: gfm-guides-20261014-esm1b-source-brandes2023-supplementary-table-2

areas: dna-genomes; protein-function
contexts: clinical_research
url: https://static-content.springer.com/esm/art%3A10.1038%2Fs41588-023-01465-0/MediaObjects/41588_2023_1465_MOESM3_ESM.xlsx
artifact url: https://static-content.springer.com/esm/art%3A10.1038%2Fs41588-023-01465-0/MediaObjects/41588_2023_1465_MOESM3_ESM.xlsx
doi: 10.1038/s41588-023-01465-0
version: Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10)
retrieved at: 2026-10-14T12:03:21Z
artifact sha256: 093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2
publication status: peer_reviewed
licence: CC BY 4.0
media type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
venue: Nature Genetics
year: 2023
source locator: Sheets 'Contents', 'Table_of_results_ClinVar', 'Table_of_results_HGMD'
archive member: artifacts/brandes2023-supplementary-table-2.xlsx.gz
archive sha256: 00efa2694f9fcb43f7dd346a24838866449d301c565ac4e26f6fa5c86d5bec64
review: method: source-hash-verification; method note: Re-downloaded on 2026-10-14; SHA-256 matches, as does the archived copy.; reviewer: claude; reviewer note: Claude (Opus 5.5) research agent, independent of the extractor; no human review claimed; date: 2026-10-14; artifact sha256: 093c32e4156a801c0dd809a437c87818a4f1d04df92e037cf40222471a3e72e2; retrieval url: https://static-content.springer.com/esm/art%3A10.1038%2Fs41588-023-01465-0/MediaObjects/41588_2023_1465_MOESM3_ESM.xlsx; note: Independent review 2026-10-14.

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