rewirebio.iobenchmarks
Protocol

Scaffold-Lab unconditional generation: Rank

Rank of the method within the length group. Measured in the Scaffold-Lab unconditional generation pipeline: 100 backbones per length, 10 ProteinMPNN sequences each, refolded with ESMFold.

10 evaluations · 10 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

10 recorded evaluations, 10 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

10 evaluations · 10 results. Different protocols are not a single leaderboard.

Protocol: Scaffold-Lab unconditional generation: Rank · Dataset: Scaffold-Lab generated backbones (100 per length group)

Sorted by Rank (rank within the length group by mean TOPSIS relative closeness; Short group) (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationRank (rank within the length group by mean TOPSIS relative closeness; Short group)Rank (rank within the length group by mean TOPSIS relative closeness; Medium group)Rank (rank within the length group by mean TOPSIS relative closeness; Long group)
FrameFlow (Scaffold-Lab unconditional generation)Evaluation1 (best in column)Not reportedNot reported
Genie (Scaffold-Lab unconditional generation)Evaluation2Not reportedNot reported
Chroma (Scaffold-Lab unconditional generation)Evaluation3Not reportedNot reported
FrameDiff (Scaffold-Lab unconditional generation)Evaluation4Not reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)Evaluation5Not reportedNot reported
Chroma (Scaffold-Lab unconditional generation)EvaluationNot reportedNot reported2
Chroma (Scaffold-Lab unconditional generation)EvaluationNot reported3Not reported
FrameDiff (Scaffold-Lab unconditional generation)EvaluationNot reported2Not reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationNot reportedNot reported1 (best in column)
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationNot reported1 (best in column)Not reported
All 10 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Chroma (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
2 Rank (rank within the length group by mean TOPSIS relative closeness; Long group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Chroma Rank on Scaffold-Lab unconditional generation, Long group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'Chroma', column 'Rank'
Configuration: Chroma (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
3 Rank (rank within the length group by mean TOPSIS relative closeness; Medium group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Chroma Rank on Scaffold-Lab unconditional generation, Medium group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'Chroma', column 'Rank'
Configuration: Chroma (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
3 Rank (rank within the length group by mean TOPSIS relative closeness; Short group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Chroma Rank on Scaffold-Lab unconditional generation, Short group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'Chroma', column 'Rank'
Configuration: FrameDiff (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
2 Rank (rank within the length group by mean TOPSIS relative closeness; Medium group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

FrameDiff Rank on Scaffold-Lab unconditional generation, Medium group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'FrameDiff', column 'Rank'
Configuration: FrameDiff (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
4 Rank (rank within the length group by mean TOPSIS relative closeness; Short group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

FrameDiff Rank on Scaffold-Lab unconditional generation, Short group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'FrameDiff', column 'Rank'
Configuration: FrameFlow (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
1 Rank (rank within the length group by mean TOPSIS relative closeness; Short group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

FrameFlow Rank on Scaffold-Lab unconditional generation, Short group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'FrameFlow', column 'Rank'
Configuration: Genie (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
2 Rank (rank within the length group by mean TOPSIS relative closeness; Short group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Genie Rank on Scaffold-Lab unconditional generation, Short group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'Genie', column 'Rank'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
1 Rank (rank within the length group by mean TOPSIS relative closeness; Long group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Rank on Scaffold-Lab unconditional generation, Long group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion', column 'Rank'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
1 Rank (rank within the length group by mean TOPSIS relative closeness; Medium group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Rank on Scaffold-Lab unconditional generation, Medium group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion', column 'Rank'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Rank
Dataset: Scaffold-Lab generated backbones (100 per length group)
5 Rank (rank within the length group by mean TOPSIS relative closeness; Short group)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Rank on Scaffold-Lab unconditional generation, Short group

lit-structure-20261011-scaffoldlab-protocol-rank

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'RFdiffusion', column 'Rank'

Source checking is not independent reproduction. Release 2026-10-23-5347695500ed.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

External evaluations
10

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Select a task-valid null control after reviewing inputs and metric

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Select an upstream conventional reference after reviewing the full protocol

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-23-5347695500ed. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

Run instructions

No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-23-5347695500ed
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Sources and history

Release 2026-10-23-5347695500ed · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: lit-structure-20261011-scaffoldlab-protocol-rank

areas
protein-structure
contexts
research
protocol
Per method and length, 100 backbones are generated, 10 sequences are designed for each with ProteinMPNN and refolded with ESMFold; the metrics are group means without data preprocessing. Ranking uses TOPSIS with CRITIC weighting.
metric
rank
metric direction
lower
unit
unitless
metric qualifier
rank within the length group by mean TOPSIS relative closeness
version
As published 2026
source locator
Table 3, column 'Rank'; Metrics section
aggregation
Mean within each length group without data preprocessing
limitations
Group means only; the per-backbone values are not published in the article.
unit detail
ordinal position within the length group
Related records

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