rewirebio.iobenchmarks
Configuration

RFdiffusion (Scaffold-Lab unconditional generation)

Configuration of RFdiffusion: Diffusion-based method, released 2023-04; run inside the Scaffold-Lab pipeline on shared hardware.

51 evaluations · 51 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

51 evaluations · 51 results. Different protocols are not a single leaderboard.

Dataset: Scaffold-Lab generated backbones (100 per length group)

Sorted by Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 100) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationProtocol and datasetDesignability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 100)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 1000)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 200)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 300)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 400)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 50)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 500)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 600)Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 800)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 100)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 1000)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 200)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 300)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 400)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 50)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 500)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 600)Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 800)Rank (rank within the length group by mean TOPSIS relative closeness; Long group)Rank (rank within the length group by mean TOPSIS relative closeness; Medium group)Rank (rank within the length group by mean TOPSIS relative closeness; Short group)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 100)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 1000)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 200)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 300)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 400)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 50)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 500)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 600)Runtime (average time taken to generate each backbone over 100 backbones per group, on identical hardware; length 800)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 100)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 1000)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 200)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 300)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 400)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 50)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 500)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 600)TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 800)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, mean over the lengths in the group; Long group)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, mean over the lengths in the group; Medium group)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, mean over the lengths in the group; Short group)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 100)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 1000)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 200)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 300)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 400)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 50)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 500)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 600)Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 800)
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)0.956Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.178Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.689Not reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.351
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.558Not reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.51Not reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.541Not reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.515Not reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.36Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.116Not reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reported0.384Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.654Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.465Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reportedNot reported0.952Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reportedNot reportedNot reported0.884Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reportedNot reportedNot reportedNot reported0.827Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reported0.722Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Designability(↑)Not reportedNot reportedNot reportedNot reportedNot reported0.726Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported1Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.891Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported1Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.63Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.67Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.76Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.87Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.35Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Diversity (↑)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.12Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported54.4Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported20.3Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported37.4Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported2.54Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported6.32Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported10.3Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported14Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported1.05Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Efficiency (↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.54Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Mean CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.406Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Mean CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.531Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Mean CiNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.238Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.738Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.609Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.677Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.65Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.614Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.591Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.596Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.707Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: Novelty(↓)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.864Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: RankNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported1Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: RankNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported1Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
RFdiffusion (Scaffold-Lab unconditional generation)EvaluationScaffold-Lab unconditional generation: RankNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported5Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
All 51 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.178 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 1000)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 1000

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 1000, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.689 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 600)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 600

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 600, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.351 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 800)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 800

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 800, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.558 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 200)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 200

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 200, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.51 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 300)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 300

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 300, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.541 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 400)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 400

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 400, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.515 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 500)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 500

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 500, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.36 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 100)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 100

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'RFdiffusion' / length 100, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Ci
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.116 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 50)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Ci on Scaffold-Lab unconditional generation, length 50

lit-structure-20261011-scaffoldlab-protocol-ci

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'RFdiffusion' / length 50, column 'Ci'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.384 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 1000)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 1000

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 1000, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.654 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 600)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 600

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 600, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.465 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 800)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 800

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 800, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.952 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 200)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 200

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 200, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.884 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 300)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 300

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 300, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.827 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 400)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 400

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 400, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.722 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 500)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 500

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 500, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.956 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 100)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 100

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'RFdiffusion' / length 100, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Designability(↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.726 Designability (Table 3 'Designability' column, printed as a group mean without data preprocessing; the Metrics section counts a backbone as designable when the mean sc-TM of its top 3 ProteinMPNN sequences refolded with ESMFold exceeds 0.5 (equation 1); the table does not state whether the value is the share of designable backbones or a mean sc-TM; not comparable with the 2 Angstrom sc-RMSD criterion in the concept definition; length 50)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Designability(↑) on Scaffold-Lab unconditional generation, length 50

lit-structure-20261011-scaffoldlab-protocol-designability

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'RFdiffusion' / length 50, column 'Designability(↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Diversity (↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
1 Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 1000)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Diversity (↑) on Scaffold-Lab unconditional generation, length 1000

lit-structure-20261011-scaffoldlab-protocol-diversity

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 1000, column 'Diversity (↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Diversity (↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.891 Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 600)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Diversity (↑) on Scaffold-Lab unconditional generation, length 600

lit-structure-20261011-scaffoldlab-protocol-diversity

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 600, column 'Diversity (↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Diversity (↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
1 Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 800)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Diversity (↑) on Scaffold-Lab unconditional generation, length 800

lit-structure-20261011-scaffoldlab-protocol-diversity

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 800, column 'Diversity (↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Diversity (↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.63 Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 200)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Diversity (↑) on Scaffold-Lab unconditional generation, length 200

lit-structure-20261011-scaffoldlab-protocol-diversity

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 200, column 'Diversity (↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Diversity (↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.67 Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 300)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Diversity (↑) on Scaffold-Lab unconditional generation, length 300

lit-structure-20261011-scaffoldlab-protocol-diversity

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 300, column 'Diversity (↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Diversity (↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.76 Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 400)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Diversity (↑) on Scaffold-Lab unconditional generation, length 400

lit-structure-20261011-scaffoldlab-protocol-diversity

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 400, column 'Diversity (↑)'
Configuration: RFdiffusion (Scaffold-Lab unconditional generation)Protocol: Scaffold-Lab unconditional generation: Diversity (↑)
Dataset: Scaffold-Lab generated backbones (100 per length group)
0.87 Proportion (unique Foldseek-Cluster clusters divided by the number of backbones in the group, clustering TM-score threshold 0.5; group mean without data preprocessing; length 500)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RFdiffusion Diversity (↑) on Scaffold-Lab unconditional generation, length 500

lit-structure-20261011-scaffoldlab-protocol-diversity

Aggregation: Not reported

Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 500, column 'Diversity (↑)'

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Technical metadata and extraction receipts

Stable ID: lit-structure-20261011-scaffoldlab-config-rfdiffusion

areas
protein-structure
contexts
research
method types
specialist
reported name
RFdiffusion
reported configuration
Diffusion-based method, released 2023-04; run inside the Scaffold-Lab pipeline on shared hardware
source locator
Table 1, row 'RFdiffusion'; Table 3 row labels
missing metadata
version: reason: unreported; note: Table 1 gives the repository and release date, not a version
provenance note
RFdiffusion as run in the Scaffold-Lab unconditional generation benchmark, with ProteinMPNN sequence design and ESMFold refolding.
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