Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.222 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 1000)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 1000
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'Chroma' / length 1000, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.516 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 600)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 600
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'Chroma' / length 600, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.325 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 800)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 800
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'Chroma' / length 800, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.275 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 200)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 200
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'Chroma' / length 200, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.398 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 300)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 300
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'Chroma' / length 300, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.262 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 400)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 400
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'Chroma' / length 400, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.249 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 500)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 500
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'Chroma' / length 500, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.437 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 100)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 100
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'Chroma' / length 100, column 'Ci' Configuration: Chroma (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.368 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 50)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Chroma Ci on Scaffold-Lab unconditional generation, length 50
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'Chroma' / length 50, column 'Ci' Configuration: FrameDiff (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.524 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 200)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameDiff Ci on Scaffold-Lab unconditional generation, length 200
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'FrameDiff' / length 200, column 'Ci' Configuration: FrameDiff (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.486 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 300)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameDiff Ci on Scaffold-Lab unconditional generation, length 300
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'FrameDiff' / length 300, column 'Ci' Configuration: FrameDiff (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.378 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 400)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameDiff Ci on Scaffold-Lab unconditional generation, length 400
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'FrameDiff' / length 400, column 'Ci' Configuration: FrameDiff (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.209 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 500)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameDiff Ci on Scaffold-Lab unconditional generation, length 500
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'FrameDiff' / length 500, column 'Ci' Configuration: FrameDiff (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.353 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 100)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameDiff Ci on Scaffold-Lab unconditional generation, length 100
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'FrameDiff' / length 100, column 'Ci' Configuration: FrameDiff (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.378 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 50)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameDiff Ci on Scaffold-Lab unconditional generation, length 50
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'FrameDiff' / length 50, column 'Ci' Configuration: FrameFlow (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.525 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 100)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameFlow Ci on Scaffold-Lab unconditional generation, length 100
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'FrameFlow' / length 100, column 'Ci' Configuration: FrameFlow (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.509 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 50)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source FrameFlow Ci on Scaffold-Lab unconditional generation, length 50
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'FrameFlow' / length 50, column 'Ci' Configuration: Genie (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.551 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 100)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Genie Ci on Scaffold-Lab unconditional generation, length 100
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'Genie' / length 100, column 'Ci' Configuration: Genie (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.377 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 50)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source Genie Ci on Scaffold-Lab unconditional generation, length 50
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Short' / 'Genie' / length 50, column 'Ci' Configuration: RFdiffusion (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.178 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 1000)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source RFdiffusion Ci on Scaffold-Lab unconditional generation, length 1000
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 1000, column 'Ci' Configuration: RFdiffusion (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.689 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 600)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source RFdiffusion Ci on Scaffold-Lab unconditional generation, length 600
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 600, column 'Ci' Configuration: RFdiffusion (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.351 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 800)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source RFdiffusion Ci on Scaffold-Lab unconditional generation, length 800
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'RFdiffusion' / length 800, column 'Ci' Configuration: RFdiffusion (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.558 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 200)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source RFdiffusion Ci on Scaffold-Lab unconditional generation, length 200
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 200, column 'Ci' Configuration: RFdiffusion (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.51 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 300)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source RFdiffusion Ci on Scaffold-Lab unconditional generation, length 300
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 300, column 'Ci' Configuration: RFdiffusion (Scaffold-Lab unconditional generation) Protocol: Scaffold-Lab unconditional generation: Ci Dataset: Scaffold-Lab generated backbones (100 per length group) 0.541 Topsis relative closeness (TOPSIS relative closeness with CRITIC weights, per length; length 400)unitless · higher
Uncertainty: Not reported by the source
Coverage: Not reported scored / Not reported eligible
Independent external evaluation · Source checked Evidence concern: excluded from comparisons Table 3 Designability column: equation (1) defines a per-backbone success over 100 backbones per length, which gives two-decimal fractions, but the column prints three-decimal group means; the aggregation behind the column is not stated, and the criterion is sc-TM above 0.5, not the 2 Angstrom sc-RMSD in the store's designability concept. Do not compare these values with other designability results.Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, column 'Designability(↑)'; Metrics, equation (1)
Methods, coverage and source RFdiffusion Ci on Scaffold-Lab unconditional generation, length 400
lit-structure-20261011-scaffoldlab-protocol-ci
Aggregation: Not reported
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Medium' / 'RFdiffusion' / length 400, column 'Ci'