rewirebio.iobenchmarks
Protocol

Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate

Percentage of targets whose model exceeds the CASP16 success threshold for GDT-TS (TM-score > 0.45, GDT-TS > 0.45, INF > 0.75, lDDT > 0.75).

7 evaluations · 7 results

Overview

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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

7 recorded evaluations, 7 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

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Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

7 evaluations · 7 results. Different protocols are not a single leaderboard.

Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate · Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set

Sorted by Success rate (GDT-TS above the CASP16 threshold) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

All 7 result rows with coverage, uncertainty and sources
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Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Boltz-1 0.4.1 (Ludaic and Elofsson 2026 RNA benchmark run)Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate
Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set
46.9% Success rate (GDT-TS above the CASP16 threshold)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Boltz-1 on Monomeric RNA hard set (GDT-TS, success rate)

lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

Aggregation: Not reported

Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S7, row 'GDT-TS', column 'Boltz-1'
Configuration: Chai-1 0.6.1 (Ludaic and Elofsson 2026 RNA benchmark run)Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate
Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set
38.8% Success rate (GDT-TS above the CASP16 threshold)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Chai-1 on Monomeric RNA hard set (GDT-TS, success rate)

lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

Aggregation: Not reported

Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S7, row 'GDT-TS', column 'Chai-1'
Configuration: HelixFold3 HelixFold3/73cd80b-hpc1 (Ludaic and Elofsson 2026 RNA benchmark run)Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate
Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set
38.8% Success rate (GDT-TS above the CASP16 threshold)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HelixFold3 on Monomeric RNA hard set (GDT-TS, success rate)

lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

Aggregation: Not reported

Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S7, row 'GDT-TS', column 'HelixFold3'
Configuration: NuFold commit 169a618 (Ludaic and Elofsson 2026 RNA benchmark run)Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate
Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set
40.8% Success rate (GDT-TS above the CASP16 threshold)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NuFold on Monomeric RNA hard set (GDT-TS, success rate)

lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

Aggregation: Not reported

Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S7, row 'GDT-TS', column 'NuFold'
Configuration: RosettaFoldNA commit f761af2 (Ludaic and Elofsson 2026 RNA benchmark run)Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate
Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set
36.7% Success rate (GDT-TS above the CASP16 threshold)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RosettaFoldNA on Monomeric RNA hard set (GDT-TS, success rate)

lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

Aggregation: Not reported

Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S7, row 'GDT-TS', column 'RosettaFoldNA'
Configuration: RhoFold+ 0.0.1 (Ludaic and Elofsson 2026 RNA benchmark run)Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate
Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set
36.7% Success rate (GDT-TS above the CASP16 threshold)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

RhoFold+ on Monomeric RNA hard set (GDT-TS, success rate)

lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

Aggregation: Not reported

Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S7, row 'GDT-TS', column 'RhoFold+'
Configuration: trRosettaRNA 1.0 (Ludaic and Elofsson 2026 RNA benchmark run)Protocol: Ludaic and Elofsson 2026 Monomeric RNA hard set, GDT-TS success rate
Dataset: Ludaic and Elofsson 2026 Monomeric RNA hard set
28.6% Success rate (GDT-TS above the CASP16 threshold)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

trRosettaRNA on Monomeric RNA hard set (GDT-TS, success rate)

lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

Aggregation: Not reported

Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S7, row 'GDT-TS', column 'trRosettaRNA'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

External evaluations
7

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Protocol-specific valid geometric or structural control

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Upstream conventional structural reference with matched templates and cutoffs

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

Run instructions

No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

Strengths, limitations and unresolved questions

Evidence

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Evidence table

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Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
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Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rna3d-protocol-monomer-hard-success-gdt-ts

areas
rna-transcriptomes; protein-structure
contexts
research
protocol
Percentage of targets whose model exceeds the CASP16 success threshold for GDT-TS (TM-score > 0.45, GDT-TS > 0.45, INF > 0.75, lDDT > 0.75)
version
Ludaic and Elofsson 2026
metric
success-rate
metric direction
higher
unit
percent
source locator
Supplementary Tables S6-S7; Results first section
limitations
Independent benchmark; the authors developed none of the methods.; Easy and hard are defined by structural similarity to the PDB training data and differ for monomers and complexes.
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