rewire.itbenchmarks
Model

scGPT

scGPT learns representations of single-cell molecular measurements and supports task-specific adaptation.

Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

3 evaluations · 3 results · 3 evaluated configurations using this model

How it worksscGPT workflow
scGPT workflow1. Gene expression and vocabulary. Then: 2. scGPT encoder. Then: 3. Cell and gene representations. Then: 4. Task-specific adaptationscGPT workflow1. Gene expression and vocabulary. Then: 2. scGPT encoder. Then: 3. Cell and gene representations. Then: 4. Task-specific adaptationscGPT workflow1. Gene expression and vocabulary. Then: 2. scGPT encoder. Then: 3. Cell and gene representations. Then: 4. Task-specific adaptation

Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.

Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Overview

Model type

Generative single-cell transformer

Inputs

Gene-expression measurements with the checkpoint-matched gene vocabulary.

Outputs

Cell/gene representations and task-specific predictions after the relevant workflow.

Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

limited source coverage · Automated source review, 2026-09-23. All specifications and missing details

Evaluations and results

3 evaluations · 3 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: scGPTTask: Cell-type identification
Dataset: M.S. single-cell dataset
0.734 F1-Score
unitless · unknown

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scGPT: Cell-type identification

Native scLLM cell-type identification as reported in Table 2.

Aggregation: Not reported

Parameter-Efficient Fine-Tuning Enhances Adaptation of Single Cell Large Language Model for Cell Type Identification · Table 2, M.S. / scGPT row, F1-Score column
Configuration: scGPTTask: Cell-type annotation
Dataset: hPancreas
0.55 F1
unitless · unknown

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Result quoted from another source · Source checked
Methods, coverage and source

scGPT: Cell-type annotation

Zero-shot setting; source caption says some comparator rows come from GenePT.

Aggregation: Not reported

scELMo: Embeddings from Language Models are Good Learners for Single-cell Data Analysis · Table 1, hPancreas zero-shot / scGPT (z) row, F1 column
Configuration: scGPTTask: Cell-type structure in frozen embeddings
Dataset: Aorta single-cell dataset
0.47 Adjusted Rand Index
unitless · unknown

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scGPT: Cell-type structure in frozen embeddings

k-means on pretrained cell embeddings; agreement with original cell-type labels.

Aggregation: Not reported

GenePT: A Simple But Effective Foundation Model for Genes and Cells Built From ChatGPT · Table 2, Aorta / Cell type row, scGPT ARI column

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

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How it works, versions and access

Related profile: scGPT. This page retains the exact record and its evaluation context.

Versions and evaluated configurations

How it works

How it works

scGPT combines each gene identity with its expression-value encoding before transformer attention. The implementation supports several expression encoders and cell-pooling choices. Task heads then predict expression or cell labels; optional masking and batch objectives depend on the training configuration.

Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row
Versions and reproducibility

The May 2023 preprint reports an early 10M-cell model. The current whole-human checkpoint table reports 33M normal human cells; these sources describe different releases. The applicable input limits require configuration-specific checking.

Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row
Strengths, limitations and unresolved questions

Strengths and limitations

Limitations and conditions

Profile review details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Stable record: catalog-model-scgpt

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-23. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
PropertyDescription and evidence
Model typeGenerative single-cell transformer
Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row
ArchitectureTransformer backbone combining learned gene-token embeddings with expression-value encodings and optional batch encodings. Separate expression, cell-classification and optional masked-value or batch-discriminator heads support configured tasks.
Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row
InputsGene-expression measurements with the checkpoint-matched gene vocabulary.
Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row
OutputsCell/gene representations and task-specific predictions after the relevant workflow.
Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row
ParametersNo exact whole-human checkpoint parameter total is stated in the inspected official README, embedding loader or journal supplement. The loader reads architecture settings from the selected checkpoint’s args.json; a family label alone does not identify its weights or task heads. · Not reported in inspected sources
Sources (3)bowang-lab/scGPT: README.md; scGPT official embedding workflow implementation; scGPT Nature Methods original supplementary information · README Pretrained scGPT Model Zoo; cell_emb.py lines202-247 args.json loading and TransformerModel construction; complete original supplementary PDF inspected for parameter totals.
Known versionsWhole-human, blood, brain, heart, kidney, lung, pan-cancer and additional organ-specific checkpoint folders are listed separately. An evaluation needs its downloaded weights, args.json and vocabulary; current documentation is not an evaluated checkpoint hash.
Sources (2)bowang-lab/scGPT: README.md; scGPT official embedding workflow implementation · README Pretrained scGPT Model Zoo; cell_emb.py lines202-247 model configuration, vocabulary and checkpoint loading.
Training dataThe official whole-human release is described as pretrained on 33 million normal human cells. The corpus-construction documentation names CELLxGENE Census 2023-05-08 and filters disease=normal. The author later clarified that 2023-05-15 was assumed to be a similar replacement after the earlier snapshot disappeared; exact equality was not established.
Sources (4)bowang-lab/scGPT: README.md; scGPT official training corpus construction documentation; scGPT official CELLxGENE query configuration; scGPT author clarification of CELLxGENE corpus version · README.md lines58-62, whole-human row; data/cellxgene/README.md Configure Query List, VERSION bullet; data_config.py VERSION and VALUE_FILTER; issue233 comment2261459134 by repository MEMBER subercui, 2024-07-31.
Training cutoffThe historical corpus date is documented as CELLxGENE 2023-05-08, with a later 2023-05-15 replacement ambiguity. Neither is a verified latest-study date for every trained cell. The archived corpus and evaluated checkpoint must be identified separately. · Not reported in inspected sources
Sources (2)scGPT official training corpus construction documentation; scGPT author clarification of CELLxGENE corpus version · data/cellxgene/README.md VERSION bullet; issue233 comment2261459134 (author distinguishes historical snapshot from presumed replacement).
Context limitsThe official embed_data workflow defaults to max_length=1200 input tokens and allows the caller to change it. This is an embedding-workflow setting, not a validated universal context ceiling or proof of the setting used in a published evaluation.
SourcesscGPT official embedding workflow implementation · scgpt/tasks/cell_emb.py embed_data signature lines148-167; get_batch_cell_embeddings max_length handling and DataCollator.
Weights licenceThe inspected official model-zoo download table does not state a separate licence grant for the downloaded whole-human checkpoint. The repository MIT code licence is recorded separately; it is not treated as proof of explicit checkpoint-distribution terms. · Not reported in inspected sources
Sources (2)bowang-lab/scGPT: README.md; bowang-lab/scGPT: LICENSE · README Pretrained scGPT Model Zoo checkpoint-folder links; LICENSE software grant.
AccessOfficial project documentation and implementation: https://github.com/bowang-lab/scGPT
Sources (3)bowang-lab/scGPT: README.md; bowang-lab/scGPT: scgpt/model/model.py; scgpt-may2023: Primary paper PDF · May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row
Code licenceMIT for the repository code at commit cebd6fae655b9c585a4807daa3ac31bb764f06b4.
Sourcesbowang-lab/scGPT: LICENSE · LICENSE, MIT grant and copyright notice.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

55 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statementOriginal source and locationReview and provenance
Diagram caption
Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.
Individual claims
bowang-lab/scGPT: README.md

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: cebd6fae655b9c585a4807daa3ac31bb764f06b4
Retrieved: 2026-09-16T19:46:18.594429+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: b0503e8ca789f19f1fc2350c5aaf57b1b323bbae43b354655231b5f4a1586c83

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram caption
Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.
Individual claims
bowang-lab/scGPT: scgpt/model/model.py

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: cebd6fae655b9c585a4807daa3ac31bb764f06b4
Retrieved: 2026-09-16T19:46:18.594429+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 4ae77618cc6f12a7d1f6d946fee3f7bd5c56f3e9e103073394a590ceba5a35ed

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram caption
Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.
Individual claims
scgpt-may2023: Primary paper PDF

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: bioRxiv version posted 1 May 2023; re-inspected existing local research artifact
Retrieved: 2026-09-16T20:21:23.046376+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 4ef64d2b3431812df07c4b3e428950644ff264ec5728267c2e4692588f557419

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram steps
  • Gene expression and vocabulary
  • scGPT encoder
  • Cell and gene representations
  • Task-specific adaptation
Individual claims
bowang-lab/scGPT: README.md

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: cebd6fae655b9c585a4807daa3ac31bb764f06b4
Retrieved: 2026-09-16T19:46:18.594429+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: b0503e8ca789f19f1fc2350c5aaf57b1b323bbae43b354655231b5f4a1586c83

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram steps
  • Gene expression and vocabulary
  • scGPT encoder
  • Cell and gene representations
  • Task-specific adaptation
Individual claims
bowang-lab/scGPT: scgpt/model/model.py

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: cebd6fae655b9c585a4807daa3ac31bb764f06b4
Retrieved: 2026-09-16T19:46:18.594429+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 4ae77618cc6f12a7d1f6d946fee3f7bd5c56f3e9e103073394a590ceba5a35ed

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram steps
  • Gene expression and vocabulary
  • scGPT encoder
  • Cell and gene representations
  • Task-specific adaptation
Individual claims
scgpt-may2023: Primary paper PDF

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: bioRxiv version posted 1 May 2023; re-inspected existing local research artifact
Retrieved: 2026-09-16T20:21:23.046376+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 4ef64d2b3431812df07c4b3e428950644ff264ec5728267c2e4692588f557419

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram title
scGPT workflow
Individual claims
bowang-lab/scGPT: README.md

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: cebd6fae655b9c585a4807daa3ac31bb764f06b4
Retrieved: 2026-09-16T19:46:18.594429+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.title

Source artifact SHA-256: b0503e8ca789f19f1fc2350c5aaf57b1b323bbae43b354655231b5f4a1586c83

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram title
scGPT workflow
Individual claims
bowang-lab/scGPT: scgpt/model/model.py

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: cebd6fae655b9c585a4807daa3ac31bb764f06b4
Retrieved: 2026-09-16T19:46:18.594429+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 4ae77618cc6f12a7d1f6d946fee3f7bd5c56f3e9e103073394a590ceba5a35ed

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram title
scGPT workflow
Individual claims
scgpt-may2023: Primary paper PDF

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: bioRxiv version posted 1 May 2023; re-inspected existing local research artifact
Retrieved: 2026-09-16T20:21:23.046376+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 4ef64d2b3431812df07c4b3e428950644ff264ec5728267c2e4692588f557419

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Model type
Generative single-cell transformer
Individual claims
bowang-lab/scGPT: README.md

Original source ↗

May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: cebd6fae655b9c585a4807daa3ac31bb764f06b4
Retrieved: 2026-09-16T19:46:18.594429+00:00

source checked

automated source review · 2026-09-23

Audit details

Follow-up review of Training data, Training cutoff, Context limits, Parameters, Code licence, Weights licence, Known versions. Source locations and before/after decisions are recorded in the 23 September profile-evidence audit. Other explanatory content retains its earlier source scope. No human scientific review or independent reproduction is implied.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: b0503e8ca789f19f1fc2350c5aaf57b1b323bbae43b354655231b5f4a1586c83

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-29-06401fd5b220 · Record review: discovered

10 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: catalog-model-scgpt

areas
cells-tissues
method types
foundation model
entity level
family
version
whole-human
reported name
scGPT
access
Public code and downloadable checkpoints; use the unfine-tuned whole-human model for a new task.
method type
foundation model
historical missing metadata
checkpoint revision: not_yet_extracted; training data: not_yet_extracted; licence: not_yet_extracted
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
entity classification
review date: 2026-09-17; rationale: The cited profile describes a named learned biological predictor or representation model/family. Preserve this identity separately from task-specific fitting, individual checkpoints, pipelines and hosted access.; source ids: evidence-official-0e4dac85aa0e0ff1d4b2; evidence-official-d8e2d4f2e752370b6565; evidence-official-efa6ec9d886a21534a20; source locator: May 2023 scGPT preprint Sections 4.1–4.3 and 4.8; current scgpt/model/model.py and README pretrained model table; README.md: Pretrained scGPT Model Zoo, whole-human row; ambiguities: None recorded
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