phyloP
Tests whether the substitution rate at a site departs from the neutral rate, in either direction and optionally within a particular clade of the phylogeny.
Results are recorded on linked configurations and versions of this method. Their settings and evaluations are kept separate below.
Results on linked records
This method has no results of its own in this release. 20 linked records have results. They are not assigned to the underlying method: each record keeps its own settings and evaluations, and its scores are on its own page.
- phyloP100way_vertebrate (Cubuk et al. 2021) Configuration · configuration · 2 evaluations · 6 results
- phyloP20way_mammalian (Cubuk et al. 2021) Configuration · configuration · 2 evaluations · 6 results
- phyloP (mammalian) (Brandes et al. 2023 clinical benchmarks) Configuration · configuration · 4 evaluations · 8 results
- phyloP (primate) (Brandes et al. 2023 clinical benchmarks) Configuration · configuration · 4 evaluations · 8 results
- phyloP (vertebrate) (Brandes et al. 2023 clinical benchmarks) Configuration · configuration · 4 evaluations · 8 results
- PhyloP 100 (Evo 2 paper variant effect evaluations) Configuration · configuration · 45 evaluations · 90 results
- PhyloP 241 (Evo 2 paper variant effect evaluations) Configuration · configuration · 45 evaluations · 90 results
- PhyloP 447 (Evo 2 paper variant effect evaluations) Configuration · configuration · 45 evaluations · 90 results
- PhyloP 470 (Evo 2 paper variant effect evaluations) Configuration · configuration · 45 evaluations · 90 results
- phyloP-100way (evaluation mode not printed (Table 4 has no Eval. column), GUANinE v1.1) Configuration · configuration · 1 evaluation · 1 result
- phyloP-100way (zero-shot, GUANinE v1.1) Configuration · configuration · 1 evaluation · 1 result
- phyloP-30way (evaluation mode not printed (Table 4 has no Eval. column), GUANinE v1.1) Configuration · configuration · 1 evaluation · 1 result
- phyloP-30way (zero-shot, GUANinE v1.1) Configuration · configuration · 1 evaluation · 1 result
- phyloP-100v.plus.score (TraitGym) Configuration · configuration · 2 evaluations · 2 results
- phyloP-241m.plus.score (TraitGym) Configuration · configuration · 2 evaluations · 2 results
- phyloP100way_vertebrate rank score, dbNSFP 5.3.1a (Lee 2026) Configuration · configuration · 3 evaluations · 6 results
- phyloP17way_primate rank score, dbNSFP 5.3.1a (Lee 2026) Configuration · configuration · 3 evaluations · 6 results
- phyloP470way_mammalian rank score, dbNSFP 5.3.1a (Lee 2026) Configuration · configuration · 3 evaluations · 6 results
- phyloP (Livesey and Marsh 2025) Configuration · configuration · 6 evaluations · 7 results
- PhyloP (Pejaver et al. 2022 calibration) Configuration · configuration · 1 evaluation · 8 results
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
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Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Description Tests whether the substitution rate at a site departs from the neutral rate, in either direction and optionally within a particular clade of the phylogeny. Individual claims | Abstract: Detection of nonneutral substitution rates on mammalian phylogenies (phyloP) qa-descriptions-20261011-d-source-phylop: abstractText Version: Europe PMC core record MED/19858363 (title and abstract), Genome Research 2010 | source checked ["automated-source-review","ai-assisted-source-review"] · 2026-10-11 Audit detailsApproved. Checked the 16 Pancotti-derived descriptions word for word against PMC8921618 section 2.2, ESM therm, RaSP and ELASPIC-2 against Chu 2024, ThermoMPNN against Dieckhaus 2024, and ABYSSAL and phyloP against their abstracts; all match. Licences on the new sources are supported by Europe PMC, the PMC XML and Crossref. Field: Claim: metadata-correction-38787bc94d7f95bf5d7d Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of a Europe PMC REST search response. These responses are not byte-stable (a later retrieval can differ in JSON key order); the title and abstractText fields are the evidence. |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
2 source records and release history
- An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers · Original source · bioRxiv 2026.07.16.739080 v1, posted 2026-07-23; full-text HTML page
- Abstract: Detection of nonneutral substitution rates on mammalian phylogenies (phyloP) · Original source · Europe PMC core record MED/19858363 (title and abstract), Genome Research 2010
Technical metadata and extraction receipts
Stable ID: somatic-oncogenicity-20261009-method-phylop
- areas
- dna-genomes
- contexts
- clinical_research
- method types
- specialist
- reported name
- phyloP
- entity level
- method
- source locator
- Algorithm lists of the cited sources
- missing metadata
- version: reason: inapplicable; note: Family record; score sources are on configurations
Related records
- configuration of: phyloP100way_vertebrate (Cubuk et al. 2021)
- configuration of: phyloP20way_mammalian (Cubuk et al. 2021)
- configuration of: phyloP (mammalian) (Brandes et al. 2023 clinical benchmarks)
- configuration of: phyloP (primate) (Brandes et al. 2023 clinical benchmarks)
- configuration of: phyloP (vertebrate) (Brandes et al. 2023 clinical benchmarks)
- configuration of: PhyloP 100 (Evo 2 paper variant effect evaluations)
- configuration of: PhyloP 241 (Evo 2 paper variant effect evaluations)
- configuration of: PhyloP 447 (Evo 2 paper variant effect evaluations)
- configuration of: PhyloP 470 (Evo 2 paper variant effect evaluations)
- configuration of: phyloP-100way (evaluation mode not printed (Table 4 has no Eval. column), GUANinE v1.1)
- configuration of: phyloP-100way (zero-shot, GUANinE v1.1)
- configuration of: phyloP-30way (evaluation mode not printed (Table 4 has no Eval. column), GUANinE v1.1)
- configuration of: phyloP-30way (zero-shot, GUANinE v1.1)
- configuration of: phyloP-100v.plus.score (TraitGym)
- configuration of: phyloP-241m.plus.score (TraitGym)
- subject: phyloP: description
- configuration of: phyloP100way_vertebrate rank score, dbNSFP 5.3.1a (Lee 2026)
- configuration of: phyloP17way_primate rank score, dbNSFP 5.3.1a (Lee 2026)
- configuration of: phyloP470way_mammalian rank score, dbNSFP 5.3.1a (Lee 2026)
- configuration of: phyloP (Livesey and Marsh 2025)
- configuration of: PhyloP (Pejaver et al. 2022 calibration)